4 Photos - Nov 23, 2014
Photo: Promoter the Ile  (-262 C/T [red allele]) and (B) (CAT) -[GLU] 330C>T transition (red), is known also as -262C>T. Tyr 370/OH (blue-exon)-PMID: 10656833 resolves the 25 A-long (hydrogen peroxide) channel a constriction or narrowing of the channel leading to the heme cavity.

Produced with:
A pKa resolving tool with any of the amino acids, present in a PDB: eg. 1DGB. with approximated visually, the modeled coords. within a few kilo-bases in length, provided and than transposed onto this rendering as located in 'picked residues' of single instances, PROPKA to PYMOL Refd.
Very fast prediction and rationalization of pKa values for protein-ligand complexes.
Bas DC, Rogers DM, Jensen JH.
Proteins. 2008 Nov 15;73(3):765-83. doi: 10.1002/prot.22102.
PMID:18498103[PubMed - indexed for MEDLINE]Photo: Heme and NADPH Pockets (colored pink) was produced with:
fpocket: online tools for protein ensemble pocket detection and tracking.
Schmidtke P, Le Guilloux V, Maupetit J, Tufféry P.
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W582-9. doi: 10.1093/nar/gkq383. Epub 2010 May 16.
PMID:20478829 [PubMed - indexed for MEDLINE]Photo: pockets observed in rendering of 1SGB main chains rd.,grn.. blu. (color) oriented to ribbon structure 1DGB_A showing to the NADPH content from u. 1DGB_C. Also the main molecular channel leading to the heme distal pocket...see details image #4Photo: pockets observed in rendering of 1SGB main chains oriented to ribbon structure 1DGB_A and 1DGB_C showing the NADPH content involves residues in only two subunits. Also the main molecular channel leading to the heme distal pockets contained in the nonNaDPh wild type human catalase and variant elements there are two channels suggest separate inlet and exhaust functions for all four heme pockets