Roberto Mancini’s men are 1/8 to kick-off their title defence with victory as they begin the season as 11/8 favourites to lift the trophy, while Southampton are the same price to face the drop.
Reading are the evens favourites for relegation and begin their season with the visit of Stoke, which they are 7/5 to win, while fellow newly-promoted side West Ham are 5/4 for victory when Aston Villa visit.
Manchester United begin the task of attempting to regain the title from arch-rivals City with a trip to Everton, for which they are 4/5 favourites, while Champions League winners Chelsea are 4/9 to win when they travel to Wigan.
Sky Bet’s Football Trader Chris Spicer said: “The Saints could not have asked for a more difficult start but it may well be the perfect time to visit the Etihad Stadium with the chance to catch the champions cold.
“However, they then face Wigan, Arsenal and Manchester United in their opening four fixtures, so it will be a surprise if their relegation odds do anything other than contract during that run.”
Sky Bet’s Premier League odds: