For a full before/after of this image and a video walkthrough of how I processed it, check out this week's episode of +onOne Software Perfect Inspiration - http://www.ononesoftware.com/inspiration/episode28/
The problem with fitting so much delicious goodness into a single frame is that it becomes very easy to get lost in everything. When you're shooting at a small aperture, say anywhere from f/8 - f/16, you're going to have pretty much everything in focus. Depending on how you compose your image and what is in your frame, this can lead to a relatively flat looking shot. However, even in those situations, I find that I'm more likely to shoot with a smaller aperture and get everything in focus because I know that I have tools to simulate shallow depth of field after the fact.
So, in the case with this image of this burnt down structure in Portland, OR, the original image is totally in focus from the foreground all the way to the back wall. However, because the foreground facade was the star of the show, I decided to apply a subtle amount of FocalPoint to render the background slightly out of focus. This instantly helps bring the wall to life and gives the image a 3D feel. But, I always have the insurance of having the entire image in focus should I want to go a different route down the line. It's just something to consider when you're shooting and framing up what your image is going to be.
Google Maps Location Info
In terms of processing
See the full video walkthrough of how I edited this image over here: http://www.ononesoftware.com/inspiration/episode28/