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Image-Based Monitoring of Oxygenation in Microfluidic Cell Culture.

Microfluidic devices have been established as versatile platforms to mimic various culture conditions or microenvironments in 2D and 3D tissue models. Oxygen availability in the cellular microenvironment strongly affects the cellular phenotype and metabolism. Therefore, monitoring oxygen tension inside microfluidic devices is essential, as it brings the in vitro conditions closer to real physoxia in cell culture and provides the basis for more reproducible and standardized results with maximal physiological relevance.

Find more information at https://www.genengnews.com/insights/image-based-monitoring-of-oxygenation-in-microfluidic-cell-culture/

#microfluidics #sensor #tissuemodels #oxygen
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Encuentran el “santo grial” que detecta diferentes tipos de cáncer en solo 10 minutos

Los responsables de este nuevo método de diagnóstico aseguran que es "muy barato y extremadamente sencillo".

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Científicos hallan una droga que impide la formación de metástasis

Han desarrollado una sustancia que permite la disociación de las células malignas y evita la propagación del cáncer.

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Following the state-of-art research and development in the fields of microfluidics, lab-on-a-chip, nanofluidics and more, uFluidix prepared an extensive directory of 65+ upcoming conferences in 2019.

▶️ Download & share: http://bit.ly/conferences_2019

#microfluidics #conferences2019
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On the latest episode of the science podcast This Week in Virology, Steve Goff returns to TWiV to discuss the work of his laboratory on silencing of retrovirus DNA in infected cells. When retroviruses infect cells, the viral RNA is converted to DNA which then enters the nucleus. There it is rapidly coated with histones and transcriptionally silenced by histone methylation. Only when the viral DNA integrates into the host cell chromosome does it become transcriptionally active. The mechanism by which the viral DNA is coated with histones involves a cell protein called NP220, which binds unintegrated viral DNA and recruits other proteins that methylate the histones. It is likely that a similar mechanism is involved in the silencing of any foreign DNA that enters the nucleus, including other viral DNAs. Hence viral genomes must encode antagonists of the histone silencing pathway. For the retrovirus studied by the Goff laboratory, integration into the cell genome serves to evade the silencing machinery.
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Científicos españoles confirman el éxito de un tratamiento contra el cáncer

Se trata de una investigación conjunta del Hospital Gregorio Marañón de Madrid, la Clínica Universidad de Navarra y el Hospital Ramón y Cajal para tratar pacientes de melanoma, tumor de pulmón y renal, entre otros.

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Researcher creates ‘smart silicone’ that reacts to heat and light.

Wellington nanotechnology researcher Andreas Zeller has created new techniques to make high value smart elastic silicone by incorporating nanocrystals and quantum dots. The smart elastomers have a wide range of commercial applications from smart bandages that change colour when they need changing, to soft robots for delicate surgical manipulation, to eco-friendly paints that could control their environment by absorbing or reflecting heat depending on the season.

Find more information at https://www.callaghaninnovation.govt.nz/news-and-events/researcher-creates-%E2%80%98smart-silicone%E2%80%99-reacts-heat-and-light

#microfluidics #microfabrication #silicone #innovation
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On the latest episode of the science podcast This Week in Parasitism, we solve the case of the Woman who Visited Lebanon. The clues this time were subtle, with a key the imbibing of Arak after the meal. Next, we visit Dickson's two passions: parasites and fish, specifically, trout. Our study examines how the nasal mucosa of trout are protected from the Ich parasite. Immunoglobulins, largely IgT (for IgTrout!) are made in the nasal mucosa by B cells, and these molecules coat the parasite and eliminate it. It's out last TWiP for 2018: thanks to everyone for listening this year, and we look forward to another year of parasites (and fish).
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A drug administered as an inhaled powder to supplement a common treatment for Parkinson's disease received approval for marketing from FDA. https://sciencebusiness.technewslit.com/?p=35535 #Science #Business #Technology #Health

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On the latest episode of the science podcast Immune, Stephanie takes the Immune team on a tour of neutrophils, the most abundant leukocytes (white blood cells) in mammals. These cells patrol the bloodstream, and when there is an infection, they attach to the blood vessel wall, throw out tethers and slings, and move right through into surrounding tissues! When they encounter a microbe, they have an array of defenses they throw at them, including nets made of DNA! These entrap bacteria. They are truly an amazing cell type and worthy of an hour of your time to learn more about them.
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