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Memory Molecule Limits Plasticity by Calibrating Calcium
Nestled between the highly plastic CA1 and CA3 regions, the rather inflexible neurons of area CA2 do not readily undergo synaptic plasticity, sharply contrasting the functional properties of its close neighbors.
The research is in eNeuro. (full access paywall)
Nestled between the highly plastic CA1 and CA3 regions, the rather inflexible neurons of area CA2 do not readily undergo synaptic plasticity, sharply contrasting the functional properties of its close neighbors.
The research is in eNeuro. (full access paywall)
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Google rolls out early access to new YouTube Music subscription service "YouTube Music comes with an all-new app, Google’s AI-powered search and insights, and a focus on finding new tunes."
https://tnw.to/RTuKs
https://tnw.to/RTuKs
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Julia Louis-Dreyfus to receive the 2018 Mark Twain Prize for American Humor
Julia Louis-Dreyfus is one of the most decorated actors in television history. She holds the record for the most Emmys ever won by a single performer - 11 total, six of which were consecutive wins for "Veep" - as well as a Peabody Award, Golden Globe and nine Screen Actors Guild awards. This fall, she will add the most prestigious award in comedy to her collection: the Kennedy Center's 2018 Mark Twain Prize for American Humor.
Julia Louis-Dreyfus is one of the most decorated actors in television history. She holds the record for the most Emmys ever won by a single performer - 11 total, six of which were consecutive wins for "Veep" - as well as a Peabody Award, Golden Globe and nine Screen Actors Guild awards. This fall, she will add the most prestigious award in comedy to her collection: the Kennedy Center's 2018 Mark Twain Prize for American Humor.
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NFL owners approve team-by-team anthem policy, will allow players to remain in locker room
NFL owners approved a new national anthem policy Wednesday that gives individual teams the authority to set their own anthem-related rules and permits players to remain in the locker room during the playing of the anthem, according to a person familiar with the deliberations.
NFL owners approved a new national anthem policy Wednesday that gives individual teams the authority to set their own anthem-related rules and permits players to remain in the locker room during the playing of the anthem, according to a person familiar with the deliberations.
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Eating at night, sleeping by day swiftly alters key blood proteins
Staying awake all night and sleeping all day for just a few days can disrupt levels and time of day patterns of more than 100 proteins in the blood, including those that influence blood sugar, energy metabolism, and immune function, according to new University of Colorado Boulder research published in the journal PNAS this week. "This tells us that when we experience things like jet lag or a couple of nights of shift work, we very rapidly alter our normal physiology in a way that if sustained can be detrimental to our health," said senior author Kenneth Wright, director of the Sleep and Chronobiology Laboratory and Professor in the Department of Integrative Physiology. The study is the first to examine how protein levels in human blood, also known as the plasma proteome, vary over a 24-hour period and how altered sleep and meal timing affects them. It also pinpointed 30 distinct proteins that, regardless of sleep and meal timing, vary depending upon what internal circadian time it is. The findings could open the door for developing new treatments for night shift workers, who make up about 20 percent of the global workforce and are at higher risk for diabetes and cancer. It could also enable doctors to precisely time administration of drugs, vaccines and diagnostic tests around the circadian clock. "If we know the proteins that the clock regulates, we can adjust timing of treatments to be in line with those proteins," said lead author Christopher Depner, a postdoctoral researcher in the Department of Integrative Physiology...Researchers drew blood every four hours and used technology recently developed by Boulder-based SomaLogic, Inc to assess levels and time-of-day-patterns of 1,129 proteins. They found 129 proteins whose patterns were thrown off by the simulated night shift.
Staying awake all night and sleeping all day for just a few days can disrupt levels and time of day patterns of more than 100 proteins in the blood, including those that influence blood sugar, energy metabolism, and immune function, according to new University of Colorado Boulder research published in the journal PNAS this week. "This tells us that when we experience things like jet lag or a couple of nights of shift work, we very rapidly alter our normal physiology in a way that if sustained can be detrimental to our health," said senior author Kenneth Wright, director of the Sleep and Chronobiology Laboratory and Professor in the Department of Integrative Physiology. The study is the first to examine how protein levels in human blood, also known as the plasma proteome, vary over a 24-hour period and how altered sleep and meal timing affects them. It also pinpointed 30 distinct proteins that, regardless of sleep and meal timing, vary depending upon what internal circadian time it is. The findings could open the door for developing new treatments for night shift workers, who make up about 20 percent of the global workforce and are at higher risk for diabetes and cancer. It could also enable doctors to precisely time administration of drugs, vaccines and diagnostic tests around the circadian clock. "If we know the proteins that the clock regulates, we can adjust timing of treatments to be in line with those proteins," said lead author Christopher Depner, a postdoctoral researcher in the Department of Integrative Physiology...Researchers drew blood every four hours and used technology recently developed by Boulder-based SomaLogic, Inc to assess levels and time-of-day-patterns of 1,129 proteins. They found 129 proteins whose patterns were thrown off by the simulated night shift.
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Kevin Harvick on the All-Star race: "I think when you look at NASCAR in 5 years. I think you'll look back and say it looks like this and it all started here." https://racingnews.co/2018/05/23/kevin-harvick-expects-the-future-of-nascar-to-look-like-the-all-star-race-did/
Tags: #kevinharvick #nascar #nascarcupseries
Tags: #kevinharvick #nascar #nascarcupseries
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#BREAKING: Federal Judge rules President Trump can't block users from his Twitter feed, says it violates users' First Amendment right. http://nbcbay.com/huzv7ER
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Cumbria and the Lake District: Spring 2018, No. 12
https://www.iancylkowski.com/cumbria-spring-2018/
It's possible to get up-close and personal with the top of Stockghyll Force in Ambleside, just make sure you've got a steady foot. When we hiked this gorge the day was rather hazy, producing a soft light that was perfect for shooting waterfalls. However, upon scrambling down to get to this view of Upper Stockghyll Force the sun finally broke through and illuminated the whole scene in golden light.
https://www.iancylkowski.com/cumbria-spring-2018/
It's possible to get up-close and personal with the top of Stockghyll Force in Ambleside, just make sure you've got a steady foot. When we hiked this gorge the day was rather hazy, producing a soft light that was perfect for shooting waterfalls. However, upon scrambling down to get to this view of Upper Stockghyll Force the sun finally broke through and illuminated the whole scene in golden light.
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Entre-deux - Fort Boyard
Fouras -Canal de la Levée
©2018 www.fabricedenisphotography.fr
Version HD : 500px.com/photo/259157671
Fouras -Canal de la Levée
©2018 www.fabricedenisphotography.fr
Version HD : 500px.com/photo/259157671
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An expensive venture
Anyone who has ever struggled with poverty knows how extremely expensive it is to be poor.
----------------- James A. Baldwin
#pakistan #punjab #street #streetphotography
#StreetPhotographySaturday
+Street Photography Saturday curated by +Sunny Wu
#hqspStreetDoc for +HQSP Street & Documentary
+BTP Street PRO
+BTP Editors' Choice (Top Photo page)
Anyone who has ever struggled with poverty knows how extremely expensive it is to be poor.
----------------- James A. Baldwin
#pakistan #punjab #street #streetphotography
#StreetPhotographySaturday
+Street Photography Saturday curated by +Sunny Wu
#hqspStreetDoc for +HQSP Street & Documentary
+BTP Street PRO
+BTP Editors' Choice (Top Photo page)
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Some People with Synesthesia Feel Other People's Sensations of Touch, Painful and Pleasurable
There are many different types of synaesthesia, but I’ll consider just one here: mirror-sensory synaesthesia.
There are many different types of synaesthesia, but I’ll consider just one here: mirror-sensory synaesthesia.
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Spotify - Free Music Streaming Beta
https://www.testingcatalog.com/project/amp/831
8.4.55.513
No new changelogs
#spotify #music #androidmusic #musicstream #spotifybeta
https://www.testingcatalog.com/project/amp/831
8.4.55.513
No new changelogs
#spotify #music #androidmusic #musicstream #spotifybeta
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This weeks Dynasty Football 101 podcast features a complete breakdown of our 3-round SuperFlex Mock Draft. Yes, there were many surprises.
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