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"Given that there has been a tentative resurgence in testing LSD for some medical conditions, understanding the mechanism of its potent and long-lasting actions may help drug developers design more effective psychiatric drugs with fewer side effects, the researchers say."
Structure of LSD and Its Receptor Explains Its Potency

Lysergic acid diethylamide--more commonly known as "LSD" or simply "acid"--is one of the longest lasting and most potent hallucinogens, but researchers have never understood why LSD's effects linger for 12 hours or more. The key to the drug's psychedelic longevity lies in how it fits into receptors in the brain.

The research is in Cell. (full open access)

#lsd

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Antidepressant Effects of Ketamine Can Be Separated From Potential Side Effects

New preclinical evidence was put forward by investigators in a series of presentations at the recent meeting of the American College of Neuropsychopharmacology suggest that the a metabolite of ketamine can produce antidepressant-like effects in a mouse model of depression. The metabolite is produced when ketamine is broken down in the body. This finding may lead to further research to better understand ketamine's efficacy in depression and its potential side effects.

The research was presented at 55th Annual Meeting of the American College of Neuropsychopharmacology.

#depression #ketamine

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The History of LSD - From Albert Hofmann to the CIA's MKULTRA.
(Curious Minds Podcast)

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