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Psychotic symptoms in autism and predictive coding


http://link.springer.com/article/10.1007/s10803-017-3065-9

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Moving documentary that features an array of patient and caregiver stories, highlighting the significant unmet need and high cost of this disease.

http://www.pbs.org/tpt/alzheimers-every-minute-counts/home/ #AD #Alzheimer

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Why the need for "positive psychology" if the brain is "positively skewed?"

"Recent evidence suggests that a state of good mental health is associated with biased processing of information that supports a positively skewed view of the future. Depression, on the other hand, is associated with unbiased processing of such information. Here, we use brain imaging in conjunction with a belief update task administered to clinically depressed patients and healthy controls to characterize brain activity that supports unbiased belief updating in clinically depressed individuals. Our results reveal that unbiased belief updating in depression is mediated by strong neural coding of estimation errors in response to both good news (in left inferior frontal gyrus and bilateral superior frontal gyrus) and bad news (in right inferior parietal lobule and right inferior frontal gyrus) regarding the future. In contrast, intact mental health was linked to a relatively attenuated neural coding of bad news about the future. These findings identify a neural substrate mediating the breakdown of biased updating in major depression disorder, which may be essential for mental health."

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Sounds promising

Scientists May Have Reactivated The Gene That Causes Neurons To Stop Growing
http://futurism.com/scientists-may-have-reactivated-the-gene-that-causes-neurons-to-stop-growing/

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Why we're so good at reading, how the minds of psychopaths work, why it might be time to get your kid off the iPad, and much more.

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It's difficult to treat something like METH addiction when not much is known about what the drug does to the brain. In this study, researchers look for clues using a rat model that mimics human addiction patterns to discover protein and functional alterations with increasing doses.

Quantitative MRM proteomics approach characterizes brain proteome changes due to chronic escalating METH dosage in rats, showing potential avenues of investigation for therapeutic options to support and treat addicts.

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