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D-D fusion using alternate Z-pinch reactor.
On page two it shows the starship next to a Saturn V, which looks like a toothpick
More details here
http://www.icarusinterstellar.org/meet-firefly-project-icarus-workshop-update-24/

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Bussard ramjets are problematic for interstellar journey, and probably will not work for intergalactic.

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PDF report on the infamous Enzmann starship
Fusion pulse ship carrying reaction mass as a titanic sphere on its nose
h/t to +Fred Kiesche 

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A way fun design exercise for an interstellar generation-colony ship. There are things I'd do differently… but it's nice to dream… and nurse ambition. Colonized Interstellar Vessel: Conceptual Master Planning.

http://www.icarusinterstellar.org/colonized-interstellar-vessel-conceptual-master-planning/

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Taken from the io9 page, they say:

In 2012, NASA physicist Harold White revealed that he and a team were working on a design for a faster-than-light ship. Now he's collaborated with an artist to create a new, more realistic design of what such a ship might actually look like.

Realistic design? You're kidding me right? The proposed flight deck would become a 30' tall room, with the pilot at the top of it in a chair.

In what world is this a realistic design? It's not, it's someone's attempt to build the USS Enterprise. 

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Technology used for interstellar spacecraft will affect solar system infrastructure required, and detectability of human civilization.
How We Get There Matters
How We Get There Matters
centauri-dreams.org

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The Ghost Ship uses one single fusion propulsion stage for acceleration and deceleration. Deceleration is further supported by a magnetic sail system, which uses the drag of interstellar hydrogen acting on a magnetic field which decelerates the spacecraft. The fusion propulsion system is based on Deuterium – Deuterium inertial confinement fusion. Inertial confinement fusion is based on compressing a tiny pellet of fusion fuel by an ignition system, in our case a number of lasers. The fuel is compressed by these very high-power lasers to such a degree that fusion can occur. The team decided to use Deuterium – Deuterium, as Deuterium – Tritium would use large amounts of Tritium, which decays quite rapidly. This means that a prohibitively large amount of Tritium has to be stored on-board of the spacecraft. Deuterium – Helium 3 was discarded due to the difficulties associated with mining Helium 3 from the Moon or the gas giant planets.
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