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Our cells go from a single zygote in the womb to the many differentiated cells that configure organs into a coordinated community as we mature. These episodic changes over time are remembered by the cells so that when cell express division, the episodic memories are included in that expression. This mechanism of being influenced by the local environment and reflecting that influence in terms of expression later on is yet another example of the fact that the way we experience life, including reflecting what we learned in the context of our local environment, is already established on many other levels, including cellular.

https://physics.aps.org/articles/v9/147

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Early intervention in brain inflammatory pathways may improve stroke recovery

Intracerebral hemorrhage is a type of stroke characterized by the rupture of a blood vessel within the brain. When the brain is exposed to blood, local immune cells become activated, triggering inflammation that promotes ongoing injury in the days and weeks after the initial stroke event. This month in the JCI, work from Laura Sansing's lab at Yale School of Medicine examined the pathways in the brain that drive injury-producing inflammation. They identified a signaling protein that plays a pivotal role in activating immune system-mediated damage after intracerebral hemorrhage. In a mouse model, they observed that intracerebral hemorrhage-driven inflammation began to clear up at the same time as the TGF-β1 pathway was activated in local immune cells. Treating mice with TGF-β1 immediately after the initial injury reduced pro-inflammatory signals and improved motor function compared to untreated mice. In a patient population, they also observed that higher bloodstream levels of TGF-β1 in the first 3 days following intracerebral hemorrhage predicted better outcomes 3 months into recovery.

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Paralysed people inhabit distant robot bodies with thought alone

Using a head-up display and a cap that reads brain activity, for the first time three people with spinal injury have controlled a robot and seen what it sees. Alessandro is excited about the potential. “It’s a sensitive and important issue, but will certainly have a major impact on the way we all can communicate to each other,” he says. But he hopes that the implications for mental health will also be looked at. “What will happen to a person who cannot move in real life after they use this technology intensively? Will they still feel isolated or lonely?” he asks. “Any developments also need to study the impact that these technologies may have on the psychological well-being of people with various degrees of disability.”

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Allen Institute for Brain Science Announces Mapping of the Mouse Cortex in 3D

The Allen Institute for Brain Science has completed the three-dimensional mapping of the mouse cortex as part of the Allen Mouse Common Coordinate Framework (CCF): a standardized spatial coordinate system for comparing many types of data on the brain from the suite of Allen Brain Atlas resources.

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