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Il cancro della prostata è il cancro che si verifica nella prostata - una piccola ghiandola a forma di noce negli uomini che produce il liquido seminale che nutre e trasporta lo sperma.

Il cancro alla prostata è uno dei tipi più comuni di cancro negli uomini. Di solito il cancro alla prostata cresce lentamente e inizialmente è confinato alla ghiandola prostatica, dove non può causare gravi danni. Tuttavia, mentre alcuni tipi di cancro alla prostata crescono lentamente e possono richiedere un trattamento minimo o addirittura nullo, altri tipi sono aggressivi e possono diffondersi rapidamente.
#Cancroallaprostata #Cancro #alla #prostata #italia #Abirateroneacetato #farmaci #prostata #Generico #millionpharma #UK #italia #romania #Kz #russia

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Kidney stone treatment in New York and care for prostate enlargement (bph) by Metropolitan Lithotriptor Associates. A company run by urologists has state of the art urology equipment for extracorporeal shockwave lithotripsy (eswl) and for laser and other minimally invasive technologies used for prostatic enlargement.

Learn more: http://www.alliedmetromedical.com/

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Daily Health and Research Article, The Best 5 Studied Proof Foods for Reducing Risk and Treatment of Benign Prostatic Hyperplasia(BPH)
Kyle J. Norton

Benign prostatic hyperplasia(BPH) is a condition of increased numbers of cell of prostate tissues, causing partial, or sometimes virtually complete obstruction of the urinary tract.

According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50.

More than half of men between age of 60-70 are experience symptoms of BPH and only 10% are required treatment.

Suggestion of BPH is associated to nutritional status and eating habits, according to the study, 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, indicated that improper nutritional status leaind to incorrect nutritional habits and failing to improve their health, may be the cause of the development of some diet-dependent diseases, such as BPH and prostate cancer(a).

A proper diet with vegetable, fruit containing zinc may reduce the risk of the disease from initiation(b)(c).

Epidemiological studies, indicated intake of vegetables and fruits accompanied with healthy life style may be associated in prevented risk and treatment of enlarged prostate(d)(e)(f)in inhibited over production of prostate cells though antioxidant activity (g)(h).

Top 5 Foods for Reducing Risk of Benign prostatic hyperplasia(BPH)
1. Green tea
Green tea containing more amount of antioxidants than any drinks or food with the same volume, is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.

Green tea is a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years.

Because of their health benefits, they have been cultivated for commercial purposes all over the world.

In the examine the levels and activity of androgen hormones in associated to the risk of BPH, researchers indicated that application of green tea catechin, (-)epigallocatechin-3-gallate, modulated the expression androgenic activity in reduced progression of benign prostatic hyperplasia.

These result suggested that EGCG may be useful for the treatment of various hormone-related abnormalities, inckuding benign prostatic hyperplasia(29)(32)

5 alpha-reductase activity long has suspected to a significant impact in induction of early onset of benign prostatic hyperplasia,

According to the study conducted by the Ben May Institute for Cancer Research, and The Tang Center for Herbal Medicine Research, administration of green tea catechin (-)-epigallocatechin gallate (EGCG) exerts a strong effect in replaced the gallate ester with long-chain fatty acids in acting as a potent 5 alpha-reductase inhibitors(30).

The study by the Oregon State University, also indicated that the combination of soy and tea attenuated prostate malignancy by decreasing prostate hyperplasia in male noble rats implanted with estradiol and testosterone(31)


2. Coffee
Coffee made from the roasted seeds of the genus Coffee, belongings to the family Rubiaceae native to southern Arabia.

According to Dr. Morrison AS. coffee drinking was inversely but only weakly related to prostatic hypertrophy(BPH) in 910 residents of Rhode Island who had a partial or total prostatectomybetween the years 1985-1987(33).

In a study of a total of 1369 patients younger than 75 years old surgically treated for BPH and 1451 controls younger than 75 years of age, the prevalence of BPH was insignificantly among coffee drinkers(34)(35)

However, according to the study by the Univ Estadual Paulista (UNESP) in the rat prostate gland, chronic caffeine intake from puberty may increase androgenic signalling and cell proliferation in initiated development of benign prostatic hyperplasia(36).

3. Pumpkin seeds
Pumpkin seed(PS) or pepita, an edible seed of a pumpkin with flat, dark green color is the genus Cucurbita and belonging to the family Cucurbitaceae.

The origin of pumpkins is unknown, although many people believe that they have originated in North America.

According the study of 20 male Wistar rats, conducted by the Michael Okpara University of Agriculture, injection of pumpkin seeds inhibited the induction of BPH and through increasing the testosterone:estradiol ratio(37).

In a randomized, double-blind, placebo-controlled trial in over 12 months on 47 benign prostatic hyperplasia patients with average age of 53.3 years and international prostate symptom score over 8, researchers showed that PS demonstrated a positive effect in treatments of benign prostatic hyperplasia(38).

Other study also suggested that oral administration of pumpkin seed oil inhibits testosterone-induced hyperplasia of the prostate(39).

4. Coconut oil
Coconut palm tree is a genus cocos, belongings to the family Arecaceae, native to the tropic and subtropic area.
According to chemical differentiation, coconut oil may reduce total cholesterol, triglycerides, phospholipids, LDL, and VLDL cholesterol levels and increased HDL cholesterol in serum, etc through numbers of phytochemicals.(40).

Coconut oil reduced the increase of both prostate weight (PW) and body weight (BW) ratio, markers in testosterone-induced PH in rats(41).

5. Fish oil
Fish oil, rich in long-chain polyunsaturated essential fatty acids of the omega-3 group may have a potential effect in reduced BPH risk.

According to the study by the University of California at Davis, gamma-linolenic acid (GLA) from fish oil inhibited 80% of gamDHT-enhanced activity of 5 alpha-reductase(42).

Other, in the study of the serum samples of 24 BPH and 19 PC patients, and from 21 age-matched normal male subjects, scientists found that the omega-3 PUFAs level was significantly decreased in patient with BPH(43).

However, in the study to compare the levels of n-3 polyunsaturated fatty acids (PUFAs) in leukocytes and prostate tissue in men with prostate cancer or benign prostatic hyperplasia (BPH), scientists found that long-chain polyunsaturated essential fatty acids intake is not associated in reduced risk of BPH(44).

Taking altogether, certain foods have been found effectively in reduced risk and treatments of Benign prostatic hyperplasia(BPH). But large sample and multi centers studies are necessary for reconfirm the viability.

Reprint of this article is welcome with author name and link back to the article intact https://kylejnorton.blogspot.ca/2018/02/the-best-5-dietary-studied-proof-foods.html

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Top 10 Studied Proof Veggies in Prevention and Treatment of Prostate Cancer
Kyle J. Norton


The widespread of prostate cancer, once considered a disease of aging male, now have become major concerns of governments and scientific community in South East Asian, because of its tendency to effect even younger age population.

Suggestions emerged of over consuming bad fats in any time in history accompanied with unhealthy diet and life style may be the possible causes of the disease, linking to the economic prosperity over 2 decades.

Foods for diseases' management have been prescribed in folk medicine over thousands of year as one of best medicine of nature in preventing and treating diseases, including prostate cancer.

Prostate cancer is medical condition caused by irregular cell growth in the prostate tissue. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during physical (rectum) exams.

1. Cruciferous vegetables
Cruciferous vegetables are the group of vegetables belongings to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli....

Indole-3-carbinol, a major chemical compound in Crucifers, is effective in inhibited prostate cancer through inducing phases I and II detoxification pathways and suppressing prostate cancer progression, through down-regulated cell signaling pathways(1).

Its derivative 3,3'-Diindolylmethane (DIM), activated the AMPK(regulator of cellular energy homeostasis) signaling pathway in induction of apoptosis in both androgen-sensitive prostate cancer cells(2).

Erucin (ER), derived from Isothiocyanates (ITCs) in crucifers, displayed a strong anti progressive prostate cancer through increased significantly p21 protein expression (regulator of cell cycle progression at G1 and S phase) and ERK1/2 phosphorylation(cell regulation) in a dose-dependent manner(3).

Sulforaphane (SFN) in crucifers also inhibited prostate cancer cell line through impacting epigenetic pathways(4).

2. Tomato
Tomato is a red, edible fruit, genus Solanum, belongings to family Solanaceae, native to South America, grown world wide for commercial purpose and often in green house.

Studies linking tomato in reduced risk of prostate caner have produced inconsistent results.(5)(6)(7)(8)(9).

Regardless to these mixed results, intake of lycopene and specific tomato products acknowledged by many researchers is associated in reduced risk prostate cancer.

Lycopene, a lipid soluble carotenoid molecule and Alpha (α)-tomatine, a saponin presented in tomato, exerted potential tumor suppressing effects by increased apoptosis and lower proliferation of tumor cells.(10)(11).

According to the Northwestern University Medical School, in a recent prospective dietary analysis, lycopene was found to have clearest inverse relation to the development of prostate cancer(12)(13).

In Androgen-independent DU145 prostate cancer cells, Apo-lycopenals or other lycopene metabolites, significantly reduced cell proliferation through alteration of the normal cell cycle(14).

In BALB/c nude mice, lycopene caused DU145 cells to accumulate in the G(0)/G(1) (Cell cycle)phase and undergo apoptosis in a dose-dependent manner(15).

3. Garlic
Garlic is a natural superfood healer for its natural antibiotic with antiviral, antifungal, anticoagulant and antiseptic properties.

Garlics intake, are related to decreased risk of prostate cancer(17).

In a reviewed study with evidence from 132,192 subjects(18). S-allylcysteine (SAC) derived from garlic, suppressed the proliferation of PC-3 cells and induced cell cycle arrest at the G0/G1 Cell cycle)phases, accompanied by the decreased expression of Bcl-2 and increased expression of Bax and caspase 8(19).

Diallyl disulfide (DADS) another compound in garlic, at 25 and 40 microM concentrations induced cell cycle arrest and apoptosis in PC-3 cells through increased expression of caspases(extent of apoptosis)(20) (3, 9, and 10), proapoptotic protein Bax(Apoptosis regulator)(21).

4. Sweet potato
Sweet potato is a large, starchy, sweet tasting tuberous roots vegetable, genus Ipomoea, belongings to the family Convolvulaceae. I

ts young leaves can be made into a delicious dish in Chinese foods but some species of batatas are actually poisonous.

Sweet potato (Ipomoea batatas) leaves, a favor vegetable consumed extensively in Africa and Asia, containing rich sources of dietary polyphenols (anthocyanins and phenolic acids) exerted a significant antiproliferative activity in some prostate cancer cell lines without damaging to normal prostate epithelial cells.

SPGE (Sweet potato extract) altered cell cycle progression, reduced clonogenic survival, modulated cell cycle and apoptosis regulatory molecules and induced apoptosis in human prostate cancer PC-3 cells both in vitro and in vivo(22).

In nude mice testing, the extract inhibited growth and progression of prostate tumor xenografts by ~75%(23).

5. Ginger
Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belongings to the family Zingiberaceae, native to Tamil, used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Ginger extract (GE) and 6-gingerol. a chemical constituent found in ginger root, synergistically inhibited proliferation of PC-3 cells(24).

Daily oral feeding of 100 mg/kg body weight of GE, inhibited growth and progression of PC-3 xenografts by approximately 56 % in nude mice and reduced proliferation index and widespread apoptosis compared with controls(25).

In the comparison of GE and an artificial quasi-mixture (Mix) formulated by combining four most-active ginger constituents at concentrations equivalent, GE showed 2.4-fold higher tumor growth-inhibitory efficacy than Mix in human prostate tumor xenografts(26).

6. Spinach
Suggestion of intake of typical green and yellowvegetable and spinach were associated to reduce risk factors for prostate cancer(27) and risk of aggressive prostate cancer decreased with increasing spinach consumption(28).

Spinach extract (NAO) expressed anti profileration of the human PCA cell line PC3 by NAO-induced G1 delay and prolonged cell cycle prolongation as a result of downregulation of the protein expression of ppRb(tumour suppressor pathway)(29)and E2F transcription factors(30).

In human prostatic cancer (PCA) cell lines DU145 and PC3, the extract attenuated cellular proliferation occurred in a dose-dependent manner, through increasing numbers of G1 cells (Cell cycle)and reducing ROS(reactive oxygen species) levels(31).

7. Chili pepper
Chili pepper is the fruit of plants from the genus Capsicum, belongings to the nightshade family, Solanaceae, used in human history for spices and cultivated for commercial profits.


Capsaicin, a chemical constituent of chili pepper demonstrated a antiproliferative activity correlated to oxidative stress in induction of apoptosis thorough suppressef the growth of human prostatecarcinoma cells in vitro and in vivo(32) and induced apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax(33)(34).

Capsaicin in other study induced apoptosis in PC-3 cells(Prostate cancer) via ROS(reactive oxygen species) generation, JNK(tumorigenetic regulator) activation, ceramide accumulation, and second, extracellular signal-regulated protein kinase (ERK) activation(35).

8. Carrot
Studies of dietary intake of the carotenoids beta-carotene and lycopene found in carrot for its reduced risk of prostate cancer has produced some inconsistent results.

Some studies suggested that dietary intake of beta-carotene was largely unassociated with prostate cancer risk, whereas intake of lycopene and tomato-based foods was weakly associated with a reduced risk(36).

In antioxidant study, some researchers suggested that beta-carotene supplementation in men with low dietary beta-carotene intakes were associated with reduced risk of prostate cancer(37) and vegetable and carotene intake was associated with lower risk of prostate cancer among Japanese(38).

Unfortunately, there is a report of intake of beta-carotene supplement may increase prostate cancer incidence, 23% higher in mortality, 15% higher in comparison with those not receiving(39).

9. Mushroom
Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source, belongings to the family Amanitaceae, cultivated in many cultures all over the world for foods and health benefits.

Mushroom Inonotus obliquus (I. obliquus) petroleum ether and ethyl acetate fractions was effectively against human prostate cancer cell line PC3 by inhibition effects on NO production and NF-κB luciferase activity in cells produced by the differentiation of white blood cells in RAW 264.7 cells and cytotoxicity(40).

Also in human androgen-independent cancer PC-3 cells, water-soluble extract (POE) of the fresh oyster mushroom exerted most significant cytotoxicity on PC-3 cells in comparison to 2 other mushroom species with cytotoxicity and induced apoptosis mediated in dose-dependent manner(41).

Polysaccharide-K® (PSK), an extract of the mushroom, induced significantly tumor suppression through reduction of tumor proliferation and enhanced apoptosis by lowering the decrease in number of white blood cells, accompanied by increased numbers of tumor-infiltrating CD4+ and CD8+ T cells.(42).

10. Bean sprouts
Eaten raw or cooked, bean sprouts are common ingredient in Asian cuisine, made from sprouting beans.
Isoliquiritigenin isolated from bean sprout, inhibited the migration, invasion and adhesion characteristics of DU145 human prostate cancer through decreased basal and EGF-induced cell(proliferation)migration, invasion in doses dependent manner(43).

Application of the chemical compound also reduced cell proliferation and induced apoptosis in DU145 human prostate cancer cells and MAT-LyLu (MLL) rat prostate cancer cells, through inhibition of ErbB3 signaling and the PI3K/Akt ((anti-apoptosis and increased cell proliferation)pathway(44).

Other researchers also suggested that these inhibition are associated with an evident disruption of the mitochondrial membrane potential, and the release of cytochrome c and Smac/Diablo(a mitochondrial protein), and the activation of caspase-9(apoptosis)(45).

Taken together, the findings suggested thatvegetables or their chemical compounds may process a huge effect in reduced risk, progression and treatment of the prostate cancer through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.

Sources can be found at https://kylejnorton.blogspot.ca/2018/02/top-10-studied-proof-veggies-in.html

and your comments of this article are always welcome

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Fact: The chances of getting #Prostate_Cancer are 1 in 3 if you have just one close relative with the disease. For treatments, book your appointments now @ http://www.siiut.com/prostate-cancer-treatment/ .
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Consuming large amounts of dairy products may increase your risk of developing #Prostate_Cancer. For treatments, make your appointments @ http://www.urologistindia.com/prostate_cancer/ .
#ProstateCancerCauses #ProstateCancerSymptoms #Chennai
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