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Frank Rummel
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Anti-Aging  - 
 
Aging In The Young

In a paper appearing the week of July 6 in the Proceedings of the National Academy of Sciences, the team from the U.S., UK, Israel and New Zealand introduces a panel of 18 biological measures that may be combined to determine whether people are aging faster or slower than their peers.

The data comes from the Dunedin Study, a landmark longitudinal study that has tracked more than a thousand people born in 1972-73 in the same town from birth to the present. Health measures like blood pressure and liver function have been taken regularly, along with interviews and other assessments.

"We set out to measure aging in these relatively young people," said first author Dan Belsky, an assistant professor of geriatrics in Duke University's Center for Aging. "Most studies of aging look at seniors, but if we want to be able to prevent age-related disease, we're going to have to start studying aging in young people."
Looking around at a 20th high school reunion, you might notice something puzzling about your classmates. Although they were all born within months of each other, these 38-year-olds appear to be aging at different rates.
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Frank Rummel
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Anti-Aging  - 
 
 
Not everything should be accepted gracefully. We should not accept abusive people in our lives, nor should we accept abuses at the hands of nature such as aging. Every old person on earth is a VICTIM of physical abuse. Metaphorically speaking, they are in an abusive relationship with nature that will end very badly. Society is suffering from a kind of stockholm syndrome. Because aging has gained a reputation of being unbeatable, people have learned to be helpless and now they are willing victims of aging. Someone suffering from Stockholm syndrome can develop romantic feelings for their abuser… and this is exactly what we see when it comes to aging. People don't just accept aging and death, they glorify it, romanticize it, and DEFEND IT. The truth is too painful so we deny our own victimization and pretend that aging is our friend. But there is a growing movement of people who refuse to be helpless victims. We choose to fight aging and death because we know that being alive is priceless. Join us. You can help by supporting SENS Foundation and the Transhumanist Party.
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+Diane McKenna, you are a pusillanimous, spineless, shallow person. You deserve to suffer a chronic debilitating disease when you get older (e.g., rheumatoid arthritis), break some bone that will take no less than half a year to heal (or that will require surgery to implant a prothesis), and get a perpetual tendinitis that will compromise your mobility for the rest of your life, so that you can really appreciate the virtues of being like a 25-year old.
The less relevant about ageing is your physical appearance.
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Frank Rummel
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Anti-Aging  - 
 
While immortality seems next to impossible to an intelligent person, in fact, aging is not always a given for a number of life forms. Unfortunately, humans are not one of them. Why not change this?
Most animals eventually get old and die. But a few lucky species don't seem to feel the weight of time, and just keep going and going
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Fifty-two-year-old Aubrey de Grey is the chief scientific officer at his own charity, the Strategies for Engineered Negligible Senescence (SENS) Research Foundation. The nonprofit organization focuses on applying regenerative medicine to the aging process.
That's just one of his jobs. He is also a biomedical gerontologist, published author, and editor-in-chief of the academic journal, Rejuvenation Research.
But his most difficult job is inspirer.
Since beginning his age-related SENS research in 2005, he has embarked on a quest to inspire the world to eliminate aging and extend the human life span indefinitely.
Inspiring that movement is his most difficult job. He considers the world to be in a "pro-aging trance" – people are happy to accept aging as an inevitability rather than a medical problem that science can solve.
"The problem we have today is we've got people who are willing to accept and come up with arguments against the defeat of aging," de Grey noted in a forum at The Amsterdam School of Creative Leadership. "They do it simply because they don't want to get their hopes up and they have a fear of the unknown."
Over the years, de Grey has inspired the right people, including billionaire entrepreneur and PayPal Co-Founder Peter Thiel. After the two met in 2004, Thiel cut de Grey a check to continue his anti-aging research.
Since then, Thiel has donated a total of $3.5 million to de Grey's other nonprofit, Methuselah Foundation. Methuselah's mission is to discover drugs that cure seven different types of age-related damage.
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Frank Rummel
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Anti-Aging  - 
 
Are you going to San Francisco??

It would be great see some Meerkat/Periscope DIY media coverage of the event!
 
Friends, PLEASE NOTE THE LOCATION CHANGE from Union Square to Sue Bierman Park right across the street from the Ferry Building for this Saturday's event! I'm helping to announce a public transhumanist and life extension rally and gathering next Saturday, June 27th at Sue Bierman Park (we'll be meeting at Justin Herman Plaza in the Sue Bierman park). It'll start at 2PM sharp and go for a few hours. Maria Konovalenko, myself, and others will be giving short speeches and talking to the public about transhumanism and the importance of longevity research. There is a notable TV channel that is scheduled to film the event (I just met with them all this evening). Please wear orange or black (Transhumanist Party colors), and there will be a limited amount of free t-shirts and bumper stickers available. Check out the event page and please join us! This is an excellent opportunity to put transhumanism on TV. Thanks! https://www.facebook.com/events/405934556259366/
PLEASE note the location change to Sue Bierman Park (right across from the Ferry Building): Join the transhumanist and life extension community on Saturday, June 27th at 2PM at Sue Bierman Park in San Francisco for a public rally and gathering. There will be a few short speeches on transhumanism ...
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Frank Rummel
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“This could lead to technology that enables earlier detection in individuals at risk for cancer, earlier detection of recurrences in cancer survivors, and also better and earlier assessment of how well cancer therapies are working in patients,” said Dr. Muneesh Tewari, the Ray and Ruth Anderson-Laurence M. Sprague Memorial research professor of internal medicine at the U-M Medical School and an associate professor of biomedical engineering in the College of Engineering.
 
Cancerous tumors cast off tiny telltale genetic molecules known as microRNAs and researchers have come up with an efficient way to detect them in blood.
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thanks for info
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Frank Rummel
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Anti-Aging  - 
 
"Our study shows that patients who have had the the entire vagus nerve severed were protected against Parkinson's disease. Their risk was halved after 20 years. However, patients who had only had a small part of the vagus nerve severed where not protected. This also fits the hypothesis that the disease process is strongly dependent on a fully or partially intact vagus nerve to be able to reach and affect the brain."

Read more:

http://www.sciencedaily.com/releases/2015/06/150623103609.htm
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Frank Rummel
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Anti-Aging  - 
 
The death rate from coronary heart disease has dropped 38 percent in a decade. One reason is that hospitals rich and poor have streamlined emergency treatment.
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About this community

The #SemanticWeb is the crucible in which #Anti-Aging #Medicine, #Science and #Engineering will forge a profound healing and relief from the scourge of #aging. This community welcomes all to contribute to the advancement of this cause. Dr. Aubrey D. N. J. de Grey, the noted Biomedical Gerontologist, has developed an engineering approach to curing the diseases of aging called Strategies for Engineered Negligible Senescence (SENS). Simply, he states that there are 7 deadly things that cause aging: Nuclear Mutations, Mitochondrial Mutations, Intracellular Aggregates, Extracellular Junk, Death-Resistant Cells, Cell Loss and Atrophy, and Extracellular Crosslinks. His SENS Foundation's research project can be divided into strands that correspond to the 7 areas above: OncoSENS, MitoSENS, LysoSENS, AmyloSENS, ApoptoSENS, RepleniSENS and GlycoSENS. In addition, there is the Delivery Systems strand researching ways to introduce regenerative therapies into the human body. This community is interested in SENS because it is a comprehensive program to directly solve the problem of aging. However, we are interested in aging research from other points of view. GUIDELINES Foreign language posts are welcome if they are translated with Google Translate. If your post did not get displayed, it was probably arrested by the Google Spam Bot. Spam Posts will be removed and repeat abusers will also be banned. Your posts should be informative, descriptive and present knowledge and value, not just a way to promote your biz or site or blog. Blog posts are okay if they are on topic. While techniques like cosmetic surgery, Botox injections or sheep placenta facials have their value to society, this community focuses on real anti-aging therapies to extend lifespan. Finally, decisions on which posts to include or reject are totally arbitrary. There are no clear cut borders to the anti-aging domain.
Phoenix AZ USA

Frank Rummel
owner

Anti-Aging  - 
 
I ran across this in my travels and while it is in an embryonic stage I am in favor of:

Crowdfunding The Cure For Aging

Overcoming the negative effects of aging is one of the oldest dreams of humanity, and now through the steady progress of science, we are poised to fullfil that dream. Whether this occurs in 20 years or 200 is largely a question of funding; the best way to accelerate this process is by mobilizing those who desire the option of a longer and healthier life into a cohesive social force - crowdfunding relevant research and advocating for its benefits to society. This is the purpose of lifespan.io.

+Lifespan.io is also on Twitter at https://twitter.com/LifespanIO and have a shell account on Youtube at https://www.youtube.com/user/LifespanIO?sub_confirmation=1
Lifespan.io | Crowdfunding the Cure for Aging
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Frank Rummel
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Anti-Aging  - 
 
According to a press release put out by the journal Cell, where the research was published: “The findings provide proof of principle that restoring the function of a single tumour suppressor gene can cause tumour regression and suggest future avenues for developing effective cancer treatments.”
A simple genetic tweak can turn colorectal cancer cells in mice back into healthy tissue in a matter of days, essentially reversing tumour growth, new research has revealed. The scientists are now looking for ways they can use the same approach to...
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+Frank Rummel thanks for the answer, but those all seem to be ancient technologies.

Organ transplants were done in a primitive way over 1700 years ago. It requires somebody to die to get his organs. The patients have to take immuno-suppressors till the end of their life.

Dialysis is also a workaround. The patient has no freedom, it always has to be close to the machine. That's not a permanent solution, or at least it shouldn't be.

Insulin for diabetics is again a temporary solution. Pancreas regeneration or transplant would be a proper solution.

How come there are no solutions based on telomerase, artificially grown organs (using the patient's DNA), stem-cell therapy, and other technologies that exist for a long time?

The way things are now, none of the technologies we're reading about in this group will be available to non-billionaires in the next 50 years.
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Frank Rummel
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Anti-Aging  - 
 
Xenotransplantation Can Save Lives

Each year, approximately 400,000 people die in the U.S. from lung diseases, but only 2,000 receive a lung transplant and only about 2,000 are added to the waiting list. Due to a severe shortage of donated organs, not even 1% of deaths due to lung diseases can be avoided. For this reason, scientists have been studying alternatives that could help ease the current lack of organs available. A promising technique is xenotransplantation: the transfer of living cells, tissues or organs from one species (pigs, for example) to another (humans). Researchers have been trying to overcome the genomic incompatibilities between the species with respect to the immune system, to avoid transplant rejection.
 
In May 2014, Synthetic Genomics and Lung Biotechnology, a subsidiary of United Therapeutics, teamed up to create pigs with lungs and other organs that are compatible for transplantation into humans.
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Frank Rummel
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Anti-Aging  - 
 
Curated Database Of Geroprotectors

Geroprotectors.org is intended as a tool for accelerating the process of identifying geroprotectors from a variety of existing substances through pharmacological modeling and biostatistical analysis to reveal new substances with geroprotective effects.

Database contains information about more than 250 experiments involving over 200 substances which have a geroprotective effect – from candidates to confirmed geroprotectors. Terms and keywords relevant to pharmacological interventions in ageing were used in a search of the PubMed database (http://www.ncbi.nlm.nih.gov/pubmed). We included papers comprising clear information about the model organism used, the tested substance, the experimental conditions, the age of subjects that were treated and any results. All entries are linked to the original work, making access to the raw data fast and convenient.

For descriptions of compounds and their effects on model organisms, we have used many sources with information about chemical and biological information. All substances have descriptions including data on their toxicity, clinical use, clinical trials (actual data), biological and pharmacological activities, interactions and so on.

We have divided the data about the various substances into 3 blocks.
The first block contains an image, the name of the substance, a short description and links to other chemical databases. In addition, this block includes information about the number of clinical trials performed and the current status of drug development. The second block includes information about biological, pharmacological, toxicity and longevity mechanisms. The third block describes the compound’s associations with age-related pathologies (chronic inflammation, cancer, amyloid aggregation and so on).

In summary, Geroprotectors.org is free to use for all purposes, including educational, research and commercial purposes, provided that Geroprotectors.org is cited in all presentations, publications, and so on, originating from this work.

Go to database: http://www.geroprotectors.org/
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Frank Rummel
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Anti-Aging  - 
 
 
Swarms of microscopic, magnetic, robotic beads could be scrubbing in next to the world’s top vascular surgeons—all taking aim at blocked arteries.
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Frank Rummel
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Anti-Aging  - 
 
Weaponizing The Immune System To Cure Cancer

We’re beginning to treat cancer in a whole new way. Rather than killing cancer cells directly with chemo or radiotherapy, the latest treatments are designed to promote the body’s natural immune control over the disease.

So-called immunotherapy works to stimulate the body’s own immune system to destroy the cancer. It is not a new concept and was first described more than a century ago, but for the first time it is beginning to deliver long-lasting responses, which some are daring to call cures.

Behind these advances has been a more sophisticated understanding of the relationship between the immune system and cancer, particularly how the cancer is seen as a danger by the body and can disguise itself from immune attack. The most promising immunotherapies are antibody drugs, which target key switches on immune cells and fall into two main classes: checkpoint blockers such as ipilimumab and nivolumab, which remove the cancer’s ability to switch off the immune system, and immunostimulators such as anti-CD40 and anti-4-1BB, which promote active immune responses from the body.

H/T to +Adrian Todd for this posting idea.
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Frank Rummel
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Anti-Aging  - 
 
An international research team led by Mayo Clinic oncologists has found a new way to identify and possibly stop the progression of many late-stage cancers, including bladder, blood, bone, brain, lung and kidney.
Source: National Cancer Institute Research published in Oncogene provides hope that the field of epigenetics may be another way of stopping cancer in its tracks.   Particularly aggressive, metastasizing cancer populations were shown to have a unique 'epigenomic' fingerprint, which could be used for targeting cancerous tissue and precision treatments. As suggested in this study, translating the epigenetic signature of cancer and i...
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Frank Rummel
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Anti-Aging  - 
 
Marine biologists have found that, upon amputation, the moon jellyfish rearranges existing body parts and recovers radial symmetry within a few days.
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Frank Rummel
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Anti-Aging  - 
 
We Can Make The Difference

The Coalition for Radical Life Extension is rallying like-minded people to come together to stand up for radical life extension and physical immortality. The Coalition is reaching out to groups and individuals who already have interest in radical life extension and physical immortality, in order to galvanize and focus our energy into a popular movement that is self-sustaining and expansive. This group of early adopting advocates, numbering in the thousands, is forming a platform for influencing a much broader audience, and ultimately the mainstream.

Public perceptions change when people come together to identify and rally around a particular issue or set of issues. Virtually all the values fought for and considered radical during the protest era of the 1960’s and 1970’s – women’s equality, minority rights, ending the Vietnam War -- have become mainstream perspectives today. Most recently, we have seen a transformation in attitudes towards gays, to the point where a sitting US President voices support for gay marriage. This is the scope of change we want to realize in how RLE is viewed by the public at large.

Unity within diversity

We have different views on what radical life extension, and even what to call it. People Unlimited calls it physical immortality. Pioneer telomere researcher Bill Andrews calls it curing aging. Trans-humanist Max More prefers super longevity. But what we all agree on is that the deathist paradigm has to go; it’s time to look beyond the past of dying to a future of unlimited living.

Radical life extension advocates are, by definition, free thinkers. That’s how we got here. The Coalition’s purpose is not to debate the relative merits of the various strategies for radical life extension, or to seek to homogenize its members’ views on this. Rather, we are bypassing this endless debate, and hopefully all endless debates, by focusing on a common purpose of benefit to all – altering public opinion in our favor.

Ultimately, this will help shift political discourse, media coverage, scientific research allotments, academic hiring practices, Hollywood style story-telling, even Supreme Court rulings. When public opinion shifts, the institutions follow. By establishing and maintaining this focus, which is of benefit to all, the Coalition can include a broad range of voices and interests effectively and efficiently.

Our vision:

To bring about a sea change in how radical life extension is viewed and understood, in order to generate greater support for a broad range of related initiatives from scientific research to social and psychological breakthroughs, to intellectual and artistic expression.

Join here: http://www.rlecoalition.com/contact

Source: http://www.rlecoalition.com/
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Frank Rummel
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Anti-Aging  - 
 
Google’s nanotechnology project, which would also involve a wearable magnetic device that tracks the particles, is said to be at least five years off, according to an accompanying report in the Wall Street Journal. The company is still figuring out how many nanoparticles are necessary to identify markers of disease, and scientists will have to develop coatings for the particles that will let them bind to targeted cells. One idea is to deliver the nanoparticles via a pill that you would swallow.
Google's ambition to cure death is beginning to take shape in a new product from its Google X division. Andrew Conrad, the head of the company's life sciences division announced the details of an e...
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