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Reprograming skin cells into stem cells (IN VIVO) using the Yamanaka Factors in a cyclical and short term exposure to avoid cancer!

''Prematurely aged mice lived 30 per cent longer after scientists genetically reprogrammed their cells''

more : https://www.salk.edu/news-release/turning-back-time-salk-scientists-reverse-signs-aging/

Video https://www.youtube.com/watch?time_continue=202&v=3r_p__9EHxU

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A single protein can boost blood stem cell regeneration

By secreting a protein called dickkopf-1 (Dkk1), bone progenitor cells improve the recovery and survival of blood stem cells in a culture dish and in mice whose immune systems are suppressed by irradiation.

https://www.nature.com/articles/nm.4251

https://blog.cirm.ca.gov/2016/12/05/a-single-protein-can-boost-blood-stem-cell-regeneration/
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This gun squirts stem cells and helps burn victims regrow their skin in just a few days. https://www.facebook.com/mashable/videos/10154664100134705/
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Inhibition of mTOR induces a paused pluripotent state
- Inhibition of Molecular Pathway Lets Mouse Blastocysts Survive for Weeks in the Lab! Drug-Induced Dormancy Mimics Natural Pausing!

Implications for Other Fields of Medicine
The new research could have a big impact on the field of assisted reproduction, where practitioners are currently limited by the rapid degradation of embryos once they reach the blastocyst stage. Putting blastocysts into suspended animation may avoid the compromise of freezing embryos and give practitioners more time to test fertilized blastocysts for genetic defects before implanting them, Bulut-Karslioglu said.

MTOR inhibitors are already in clinical trials to treat certain forms of cancer, but the new results suggest a potential danger of this approach, Ramalho-Santos said: “Our results suggest that mTOR inhibitors may well slow cancer growth and shrink tumors, but could leave behind these dormant cancer stem cells that could go back to spreading after therapy is interrupted. You might use a second or third line of drugs specifically to kill off those remaining dormant cells.”

https://www.ucsf.edu/news/2016/11/405016/researchers-put-mouse-embryos-suspended-animation

https://www.nature.com/articles/nature20578
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Scientists Create Incredibly Realistic Lab-Grown Skin
- http://www.vocativ.com/304045/lab-grown-skin/?utm_source=TSE&utm_medium=cpc&utm_campaign=INF&utm_content=inf_256_42_2&tse_id=INF_32d5e590afbc11e698611db1302aa2cb
- In a bioengineering breakthrough, scientists have managed to create artificial human skin in the laboratory that contains all three natural skin layers, a handful of the usual glands and even hair follicles. The findings, published in Science Advances ( http://advances.sciencemag.org/content/2/4/e1500887/tab-figures-data )
bring us one step closer to reliably regenerating realistic human skin that has been lost to severe burns and skin diseases.

Donwload: https://www.hairlosstalk.com/interact/attachments/takashi_tsuji_last_study-pdf.74892/



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Scientists may have discovered cancer stem cells in a type of brain tumour

The findings suggest that targeting these cells with treatments could help patients with this type of cancer.

"Our work strongly supports that cancer stem cells are the main source of growth in these tumours and, as such, should be considered promising targets for treatment," he added.

For the latest study, which has been published in the journal Nature (link is external), the researchers sought to find these cells in oligodendrogliomas by looking at the activity of genes in tumours from six patients with early-stage disease.

This identified a rare group of cells with patterns of gene activity that were different from those found in the majority of the tumour cells. This pattern was found to be linked with cell growth, suggesting that these particular cells are “primarily responsible for fuelling the growth of oligodendrogliomas,” the authors write in their study.

“Whether cancer stem cells exist and help tumours develop is a fundamental question in cancer biology,” Parrinello added.

“In this study, the researchers show convincingly that these cells exist in people with oligodendrogliomas.

“They also show these cells fuel the growth of this type of tumour. These results have important implications for treatment.”

http://www.cancerresearchuk.org/about-us/cancer-news/news-report/2016-11-08-scientists-discover-cells-that-may-fuel-brain-tumour-growth?utm_content=buffere0e21&utm_medium=social&utm_source=facebook.com&utm_campaign=buffer

https://www.nature.com/articles/nature20123
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Transdifferentiation, also known as lineage reprogramming, is a process in which one mature somatic cell transforms into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Current uses of transdifferentiation include disease modeling and drug discovery and in the future may include gene therapy and regenerative medicine. The term 'transdifferentiation' was originally coined by Selman and Kafatos in 1974 to describe a change in cell properties as cuticle producing cells became salt-secreting cells in silk moths undergoing metamorphosis.

Transdifferentiation in action

- The video shows a culture of B cells labeled with green fluorescent protein (GFP) surrounded by red fluorescent yeast (Candida albicans). As the transcription factor C/EBPa is activated within the B cells these aggregate and turn into macrophages that ingest the yeast, so that 51 hours after activation all pathogens became eaten. Credits: Jose Luis Sardina, Francesca Rapino and Timo Zimmermann, CRG. https://www.youtube.com/watch?v=uJq_Pa17XdY
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Laser Therapy Prompts Regeneration in Teeth

- Twelve weeks after the low-power laser treatment, more newly formed dentin, marked by yellow hashtags (#), can be seen in the laser-treated teeth (right) than in the controls (left). Harvard's Wyss Institute and SEAS

https://www.nih.gov/news-events/nih-research-matters/laser-therapy-prompts-regeneration-teeth
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