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Serotonin May Worsen Tinnitus

Millions of people suffer from the constant sensation of ringing or buzzing in the ears known as tinnitus, creating constant irritation for some and severe anxiety for others. Research by scientists at OHSU shows why a common antidepressant medication may worsen the condition.

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Fundamental ALS Pathology Discovered

Identifying the basic cellular malfunction underlying amyotrophic lateral sclerosis and a form of dementia opens the pathway to developing treatments to prevent the disease by preserving neurons.

The research is in Neuron. (full access paywall)

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Eye Test Could Predict Alzheimer's Years Before Symptoms Appear

Cedars-Sinai neuroscience investigators have found that Alzheimer's disease affects the retina -- the back of the eye -- similarly to the way it affects the brain. The study also revealed that an investigational, noninvasive eye scan could detect the key signs of Alzheimer's disease years before patients experience symptoms.

The research is in JCI Insight. (full open access)

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Therapeutic Cocktail Could Restore Motor Skills after Spinal Cord Injury and Stroke

The mixture of three molecules could potentially be given therapeutically to aid in functional recovery after injury.

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Lower Brain Serotonin Levels Linked to Dementia

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Results suggest serotonin loss may be a key player in cognitive decline, not just a side-effect of Alzheimer's disease.

The research is in Neurobiology of Disease. (full access paywall)

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New Diagnostic Kit for Duchenne Muscular Dystrophy in Newborns

Researchers at Cardiff University and Cardiff and Vale University Health Board have developed a more reliable method of screening for Duchenne muscular dystrophy (DMD) in newborn babies.

The research is in Clinical Chemistry. (full access paywall)

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Does Widespread Pain Spread From the Brain?

Whenever someone experiences pain, they often think about how intense the pain is -- but rarely do they also consider how widespread the pain is.

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Midlife Cardiovascular Risk Factors May Increase Chances of Dementia

A large, long-term study suggests that middle aged Americans who have vascular health risk factors, including diabetes, high blood pressure and smoking, have a greater chance of suffering from dementia later in life.

The research is in JAMA Neurology. (full access paywall)

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Tracking ZIKA Transmission in Mice

National Institutes of Health (NIH) scientists have developed a mouse model to study Zika virus transmitted sexually from males to females, as well as vertically from a pregnant female to her fetus. They are using the model to study how and when the virus is spread, including how the virus crosses the placenta, as well as to investigate potential treatments to block virus transmission.

The research is in Scientific Reports. (full open access)

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Missing Signals Lead to Diabetic Nerve Injury

Molecules that help cells communicate with each other--called cytokines--might be the key to repairing diabetic nerve damage, according to a new study published in Experimental Neurology. Diabetes devastates nerve cells, which can lead to poor circulation, muscle weakness, blindness, and other painful side effects. The new study showed diabetic mice can't repair nerve cells after damage due to low levels of specific cytokines.

The research is in Experimental Neurology. (full access paywall)
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