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Focusing on Early Stage of Illness May Be Key to Treating ALS

A new kind of genetically engineered mouse and an innovation in how to monitor those mice during research have shed new light on the early development of an inherited form of amyotrophic lateral sclerosis (ALS).

The research is in Nature Neuroscience. (full access paywall)

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Better Understanding ALS by Looking at How Cells Change

It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS), works.

The research is in Brain. (full access paywall)

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Cell Therapy Could Improve Brain Function in Alzheimer's

Like a great orchestra, your brain relies on the perfect coordination of many elements to function properly. And if one of those elements is out of sync, it affects the entire ensemble. In Alzheimer's disease, for instance, damage to specific neurons can alter brainwave rhythms and cause a loss of cognitive functions.

The research is in Neuron. (full open access)

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Shedding Light on the Underlying Cause of Stroke

New research shows how the novel drug QNZ-46 can help to lessen the effects of excess release of glutamate in the brain – the main cause of brain injury in stroke.

The research is in Nature Communications. (full open access)

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A Way to Restore Movement Sensation in Upper Limb Amputation Patients

Led by Paul Marasco, Ph.D., the research team has successfully engineered a sense of complex hand movement in patients with upper limb amputations. This breakthrough may enhance the ability to control their prostheses, independently manage activities of daily living and improve quality of life.

The research is in Science Translational Medicine. (full access paywall)

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Promising Therapeutic Approach for Spinal Cord Injuries

It was recognised more than a century ago that nerve fibres of the central nervous system fail to grow through the scar tissue that forms at a lesion. However, this scar tissue is a complex mesh of different cell types and molecules, and it has been unclear exactly how the scar tissue blocks nerve fibre regrowth.

The research is in Cell. (full open access)

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Domino Effect: Individual Damaged Neuron Types Cause Neurodegenerative Diseases

If the sense of smell disappears, this can indicate a disease such as Alzheimer's or Parkinson's disease. However, unlike previously assumed, general degenerations in the nervous system do not play a leading role in the loss of the sense of smell with increasing age, but individual nerve cells or classes of nerves are decisive.

The research is in eLife. (full open access)

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Brain Injury May Boost Risk of Early Onset Alzheimer's

Concussions and other traumatic brain injuries may increase the risk of developing Alzheimer's disease earlier in life, according to a study from UT Southwestern's Peter O'Donnell Jr. Brain Institute.

The research is in Neuropsychology. (full access paywall)

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Can Our Eyes Help Predict Who Will Develop Memory Loss?

People whose eyes show signs of small changes in blood vessels at age 60 may be more likely to develop thinking and memory problems by the time they are 80 than people with healthy eyes.

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The Factors that Most Affect Our Immune System

Why do we respond differently to infections or vaccines? Why are some people allergic to pollen? These are still unanswered questions in biological and medical science.

The research is in Nature Immunology. (full access paywall)
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