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Parkinson's is Partly an Autoimmune Disease

First direct evidence that abnormal protein in Parkinson's disease triggers immune response.

The research is in Nature. (full access paywall)

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Researchers Discover What May Be the Earliest Stage of Alzheimer's

Clusters of a sticky protein -- amyloid plaque -- found in the brain signal mental decline years before symptoms appear, a new study finds.

The research is in JAMA. (full access paywall)


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Western Diet Increases Alzheimer's Pathology in Genetically Predisposed Mice

Obese mice with a particular version of a gene strongly associated with Alzheimer's disease (AD) in humans show increased Alzheimer's pathology, according to new research published in eNeuro. The study suggests lifestyle changes could reduce the likelihood of developing AD in individuals with this genetic predisposition.

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Malaria Drug Lowers Levels of ALS Linked Biomarker

Decades-old drug used to treat malaria targets genetic mutation in ALS patients.

The research is in Annals of Neurology. (full open access)

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Motor Neuron Disease Discovery Offers New Insights into Potential Treatment Targets

Scientists have discovered how certain forms of motor neuron disease begin and progress at cellular and molecular levels, revealing potential new ways to slow down or even stop this process. The team are already working closely with pharmaceutical companies to use this knowledge to develop new treatments for motor neuron disease and other neurodegenerative conditions.

The research is in Cell Reports. (full open access)

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Alzheimer's, Parkinson's and Huntington's Share Common Crucial Feature

Finding suggests that treatment for one disease could work for the other two.

The research is in Acta Neuropathologica. (full access paywall)

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Supercomputer Unlocks Secrets of the Brain and Safer Anesthetics

Researchers have used a supercomputer to show how proteins in the brain control electrical signals, in a breakthrough that could lead to safer and more effective drugs and anaesthetics.

The research is in PNAS. (full access paywall)

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Experimental Therapy for Immune Diseases Hits Achilles Heel of Activated T Cells

Immune diseases like multiple sclerosis and hemophagocytic lymphohistiocytosis unleash destructive waves of inflammation on the body, causing death or a lifetime of illness and physical impairment. With safe and effective treatments in short supply, scientists report the discovery of an experimental treatment that targets an Achilles heel of activated immune cells - killing them off and stopping autoimmune damage.

The research is in PNAS. (full access paywall)

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Common Protein Abnormality Pinpointed in Parkinson's and ALS

Discovery may offer hope to Parkinson's disease and ALS patients.

The research is in Acta Neuropathologica. (full access paywall)

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Flies Are Key to Studying the Causes of Dementia

Discovery relating to brain proteins could lead to new effective therapies for dementia and other neurodegenerative diseases.

The research is in Neurobiology of Disease. (full open access)
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