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Gene Immunotherapy Protects Against Multiple Sclerosis: Mouse Study

A potent and long-lasting gene immunotherapy approach prevents and reverses symptoms of multiple sclerosis in mice.

The research is in Molecular Therapy. (full open access)

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Personality Changes Don't Precede Clinical Onset of Alzheimer's Disease

For years, scientists and physicians have been debating whether personality and behavior changes might appear prior to the onset of Alzheimer’s disease and related dementias.

The research is in JAMA Psychiatry. (full access paywall)

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Immune Cells May Heal Bleeding Brain After Strokes

While immune cells called neutrophils are known to act as infantry in the body's war on germs, a National Institutes of Health-funded study suggests they can act as medics as well. By studying rodents, researchers showed that instead of attacking germs, some neutrophils may help heal the brain after an intracerebral hemorrhage, a form of stroke caused by ruptured blood vessels. The study suggests that two neutrophil-related proteins may play critical roles in protecting the brain from stroke-induced damage and could be used as treatments for intracerebral hemorrhage.

The research is in Nature Communications. (full open access)

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Both High and Low Levels of Magnesium in Blood Linked to Dementia Risk

People with both high and low levels of magnesium in their blood may have a greater risk of developing dementia.

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Brain Rewiring in Parkinson's Disease May Contribute to Abnormal Movement

The brain's own mechanisms for dealing with the loss of dopamine neurons in Parkinson's disease may be a source of the disorder's abnormal movement.

The research is in Neuron. (full access paywall)

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Molecular Link Between Parkinson's and Prion Diseases Discovered

New research has proven the existence of an important interaction between the molecules involved in the two types of pathologies.

The research is in Scientific Reports. (full open access)

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Link Between Toxoplasma Infection and Common Brain Disease

More than 2 billion people - nearly one out of every three humans on earth, including about 60 million people in the United States - have a lifelong infection with the brain-dwelling parasite Toxoplasma gondii.

The research is in Scientific Reports. (full open access)

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Body's Own Defense Against ALS Actually Drives Disease Progression at Later Stages

Columbia scientists have discovered that one of the body's natural defenses against amyotrophic lateral sclerosis (ALS) -- a cellular 'clean-up process' called autophagy -- suppresses disease progression early on, but in later stages advances the disease's deadly spread through the spinal cord. These findings in mice provide a window into ALS's earliest stages, as well as new insights into its complexity, namely the differing roles that autophagy plays in its progression. In addition, this study can help scientists search for ways to detect and even treat the disease before the onset of devastating symptoms that gradually rob patients of movement, speech and life.

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Potential New Therapy Relieves Chronic Itch

FDA-approved arthritis drug may work in new ways to fight itch.

The research is in Cell. (full access paywall)

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Breakthrough Study Reveals New Diagnosis for Alzheimer's

Alzheimer's sufferers may now have an additional test to improve the accuracy of diagnosis in order to better tailor appropriate treatment.

The research is in PNAS. (full open access)
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