A descriptive article on this analytical study and additional information from an interview with its lead author can be found in Medscape, for those who have access: http://www.medscape.com/viewarticle/838721 [re. Medscape access see my comment below at end]
"The research team's disease-specific pathway analysis found that the top pathway for bipolar disorder is histone H3-K4 methylation. For schizophrenia, it is postsynaptic density; and for MDD, protein phosphatase type 2A regulator activity was the top pathway.
"Because these disorders overlap, the researchers also carried out analyses across disorders, sort of aggregating the signals across pathways, said Dr O'Dushlaine. For example, he explained, in bipolar disorder, the genetic association might be at the start of a pathway and [in] schizophrenia at the end of that same pathway."
"... According to the authors, histone methylation mechanisms play a role in the coordination of complex cognitive processes such as long-term memory and in conditions from addiction to schizophrenia to neurodegeneration. Histone pathways have previously been studied in cancer and with regard to the immune pathway in infectious disease."
The article continues referencing Dr O'Dushlaine: "It looks like immune genes do have a role" in mental illnesses, but because that area of the genome is so large, it will take a lot of work to "disentangle" it, he said. "
Dr O'Dushlaine, and likely that of the Medscape author, are focused on patentable pharmaceuticals. "The idea here is to design drugs that are genetically informed instead of a drug that just happens to work for whatever reason. It works because it's targeting a deficit."
Now I'm going to share a little of my bipolar history, though I've written of this before in greater detail (http://morelife.org/personal/kittyreflects/kiton031031.html). In mid-Sept 2003 I had my last manic episode, which was precipitated by a bad sinus cold, lack of restful sleep for several days, a cross-Atlantic flight with ensuing jet lag and attendance at a highly stimulating biogerontology conference. Within 3 days of our arrival in England I was clearly hypomanic, but when OTC measures (very limited in England) were unsuccessful in bringing on sleep and I became worse, husband Paul arranged for emergency return back across the Atlantic. Several weeks of intense care by Paul at home followed, w/ medical oversight by a Toronto psychiatrist including psychoactive drugs, getting me back eventually to just low dose daily lithium (which I had ceased taking many months before episode).
Since that event I've described, my immune system and overall longevity promoting practices have received far more attention than previously. I've had few sinus colds and none in past 5 yrs that I've been even more diligent with pre-emptive pulsatile nasal irrigation at the very first signs of nasal/sinus irregularity or airborne environmental pollutant exposure. Our attention to highly nutritious but low calorie diet (and intermittent fasting), regular physical activity and a judicious variety of supplements have been major parts of our healthy longevity practices during our active years of MoreLife.org. Even more so to me, with our work in developing Live120Plus.com (though Paul has been aware for decades through his own earlier studies) it has been clearly evident that the strong interplay of bodily systems can not be minimized, let alone forgotten, by concentrating on just 1, 2 or even 3 aspects.
In these 11-1/2 yrs since that last manic episode I have not come even close to a repeat. I credit it to my overall far better physical health, plus increased knowledge of the benefits of restful sleep and its practical acquisition, and also the maintenance of (at least one) close social relationship.
We at Live120Plus.com are working to provide all the information a subscriber will need to continue a current state of good health and vitality with only minor negative changes until at least 120 years of age. This is a multi-factorial challenge because healthy longevity is a multifactorial goal, involving all the many body systems. However, we are strongly convinced that scientific knowledge has now arrived at a point where enlightened actions to embrace and practice all currently known health and longevity measures, plus some reasonable good fortune, will enable us and eventual subscribers to avoid major aging dysfunctions while riding a wave of evidence-based life extending advances into the future.
So, to the longevity-seekers who have a life-sciences background and want to learn more for now usage (rather than waiting for the far future), while earning and investing in Live120Plus.com as science literature researchers and writers, see: http://live120plus.com/help-wanted AND pass the word too.
PS re. Medscape articles: I suspect that Medscape does not enable general public access to its articles as a way to limit the information that non-approved health practitioners acquire; this keeps more people seeking treatment rather than utilizing preventative measures, even if some sought advice from those more knowledgeable.
#mentalillness #longevity #lifeextension #health #mentalillness #mentalhealthawareness
Drug company Pfizer's new "Fear of Getting Old" project is glitzy but is narrow in its recommendations. The quiz too won't make much sense unless you're about 30 or well acquainted with what goes on with many that age - which I do :) And you won't get a "Chairman of the Board" score at the end, like I did, unless you're already practicing (at least) the dysfunction/degeneration that they consider beneficial. I do "the right things" as part of my work with http://Live120Plus.com
Want to learn and earn while you add value to this project for bringing it actively online? Got a science background or interest sufficient for being a science literature researcher and writer? http://live120plus.com/help-wanted
Don't miss it, the few sentences that follow and the entire blog entry. This is a message I've written, tweeted, G+d, commented on for the past 10+ years (prompted by understanding the ideas & writings of my husband, ). It was so good to see someone else, someone whose writings I admire, write virtually the same thing.
#responsibility #Accountability #War #americansniper
- Live120PlusHighly functional living to age 120 & more, 2012 - presentAdministrative Prtnr & Sci Lit Researcher
- Truths of reality & libertous societySearcher & Promoter, present
- MoreLifePromoter of more life in quality & quantity, 2000 - 2012
- MotorolaProject Mech Engineer, 1984 - 2000
- Various NursingRN, 1966 - 1982
BM ISO bson DOB 1/24/68 NYC adopted thru Cath Ch Paterson NJ - http://morelife.org/personal/kittyreflects/kiton040528.html
[translated "search" jargon: BirthMother in search of birth son Date of Birth]
- University of ArizonaMechanical Engineering, 1981 - 1983
- Holy Name Hospital School of Nursing, Teaneck NJ1963 - 1966
- Morris Hills Regional HS Rockaway NJcollege prep, 1959 - 1963
- Central Arizona Collegepre-engineering, 1977 - 1981
Tai chi is the perfect antidote to a digital age - Telegraph
Taiwanese scientists are making new claims for the health benefits of tai chi, and it’s the ideal way to slow down
Will you be cheering at your 150th birthday party? - CARP Canada
Editor’s Note: This article was forwarded by CARP Board member Bill VanGorder. The statements and opinions expressed in the article are thos
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