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Rob Daalder
Attended Delft University of Technology
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Rob Daalder

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The real reason dinosaurs became extinct (credit: Gary Larson)
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RNA editing of genomic information was thought to be sparingly used, based on a limited number of studies in mammals and flies. But recently, investigators discovered the most prolific usage yet of RNA editing in the common squid, Doryteuthis pealeii, a behaviorally sophisticated marine organism that has long been prized for studies of the nervous system.
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How to map a billion frames of mind?

Shortened edit of an article worth reading in full;
http://www.nytimes.com/2015/01/11/magazine/sebastian-seungs-quest-to-map-the-human-brain.html
 
In 2005, Sebastian Seung suffered the academic equivalent of an existential crisis. Seung was growing increasingly depressed. He and his colleagues spent their days arguing over how the brain might function, but science offered no way to scan it for the answers. “It seemed like decades could go by,” Seung told me recently, “and you would never know one way or another whether any of the theories were correct.”

That November, Seung sought the advice of David Tank, a mentor he met at Bell Laboratories. Over lunch Tank administered a radical cure. He informed Seung of a former colleague in Heidelberg, Germany, Winfried Denk, who had just built a device that imaged brain tissue with enough resolution to make out the connections between individual neurons... Less than a month later Seung arrived at the Max Planck institute where Denk introduced him to the high-resolution brain-imager he had built.

Now, eight years later, Seung has become the leading proponent of a plan to create a wiring diagram of all 100 trillion connections between the neurons of the human brain, an unimaginably vast and complex network known as the connectome. 

If science were to gain the power to record and store connectomes, then it would be natural to speculate, as Seung and others have, that technology might some day enable a recording to play again, thereby reanimating a human consciousness. The mapping of connectomes, its most zealous proponents believe, would confer nothing less than immortality.

For now he hopes to prove that he can find a specific memory in the brain of a mouse and show how neural connections sustain it.

What makes the connectome’s relationship to our identity so difficult to understand, Seung told me, is that we associate our “self” with motion. We walk. We sing. We experience thoughts and feelings that bloom into consciousness and then fade. “Psyche” is derived from the Greek “to blow,” evoking the vital breath that defines life. “It seems like a fallacy to talk about our self as some wiring diagram that doesn’t change very quickly,” Seung said. “The connectome is just meat, and people rebel at that.”

When Seung started, he estimated that it would take a single tracer roughly a million years to finish a cubic millimeter of human cortex — meaning that tracing an entire human brain would consume roughly one trillion years of labor. He would need a little help.

In 2012, Seung started EyeWire, an online game that challenges the public to trace neuronal wiring — now using computers, not pens — in the retina of a mouse’s eye. Seung’s artificial-­intelligence algorithms process the raw images, then players earn points as they mark, paint-by-numbers style, the branches of a neuron through a three-dimensional cube.

Ultimately, Seung still hopes that artificial intelligence will be able to handle the entire job. But in the meantime, he is working to recruit more help. In August, South Korea’s largest telecom company announced a partnership with EyeWire, running nationwide ads to bring in more players. In the next few years, Seung hopes to go bigger by enticing a company to turn EyeWire into a game with characters and a story line that people play purely for fun. “Think of what we could do,” Seung said, “if we could capture even a small fraction of the mental effort that goes into Angry Birds.”

https://eyewire.org/signup

To explain what he finds so compelling about the substance of the brain, Seung points to stories of near death. Like the one of a young doctor named Anna Bagenholm who miraculously recovered from being clinically dead for more than 2 hours. Even after the cold arrested Bagenholm’s heart and hushed her crackling neuronal net to a whisper, her connectome endured.


At the Janelia Research Campus you can find MERLIN, a pair of hulking beige devices, a next generation brain-imaging system. The system combines slicing and imaging: An electron microscope takes a picture of the brain sample from above, then a beam of ions moves across the top, vaporizing material and revealing the next layer of brain tissue for the microscope. It is, however, a “temperature-­sensitive beast,” said Shan Xu, a scientist at Janelia. If the room warms by even a fraction of a degree, the metal can expand imperceptibly, skewing the ion beam, wrecking the sample and forcing the team to start over. Xu was once within days of completing a monthslong run when a July heat wave caused the air-­conditioning to hiccup. All the work was lost. Xu has since designed elaborate fail-safes, including a system that can (and does) wake him up in the middle of the night; Janelia has also invested several hundred thousand dollars in backup climate control. “We’ve learned more about utilities than you would ever want to know,” Hess said.

Here at Janelia, connectome science will face its most demanding test. Gerry Rubin, Janelia’s director, said his team hopes to have a complete catalog of high-resolution images­ of the fruit-fly brain in a year or two and a completely traced wiring diagram within a decade. Rubin is a veteran of genome mapping and saw how technological advances enabled a project that critics originally derided as prohibitively difficult and expensive. He is betting that the story of the connectome will follow the same arc. Ken Hayworth, a scientist in Hess’s lab, is developing a way to cleanly cut larger brains into cubes; he calls it “the hot knife.” In other labs, Jeff Lichtman of Harvard and Clay Reid of the Allen Institute for Brain Science are building their own ultrafast imaging systems. Denk, Seung’s longtime collaborator in Heidelberg, is working on a new device to slice and image a mouse’s entire brain, a volume orders of magnitude larger than what has been tried to date. 

As connectomics has gained traction, though, there are the first hints that it may be of interest to more than just monkish academics. In September, at a Brain Initiative conference in the Eisenhower building on the White House grounds, it was announced that Google had started its own connectome project. Tom Dean, a Google research scientist and the former chairman of the Brown University computer-science department, told me he has been assembling a team to improve the artificial intelligence: four engineers in Mountain View, Calif., and a group based in Seattle. To begin, Dean said, Google will be working most closely with the Allen Institute, which is trying to understand how the brain of a mouse processes images from the eye. Yet Dean said they also want to serve as a clearinghouse for Seung and others, applying different variations of artificial intelligence to brain imagery coming out of different labs, to see what works best.

It’s possible now to see a virtuous cycle that could build the connectome. The artificial intelligence used at Google, and in EyeWire, is known as deep learning because it takes its central principles from the way networks of neurons function. This could, in the coming decades, lead to more insights about neural networks, improving deep learning itself — the premise of a new project funded by Iarpa, a blue-sky research arm of the American intelligence community, and perhaps one reason for Google’s interest. Better deep learning, in turn, could be used to accelerate the mapping and understanding of the brain, and so on.

Eve Marder, a prominent neuroscientist at Brandeis University, cautions against expecting too much from the connectome. She studies neurons that control the stomachs of crabs and lobsters. In these relatively simple systems of 30 or so neurons, she has shown that neuromodulators — signaling chemicals that wash across regions of the brain, omitted from Seung’s static map — can fundamentally change how a circuit functions. If this is true for the stomach of a crustacean, the mind reels to consider what may be happening in the brain of a mouse, not to mention a human.

“If we want to understand the brain,” Marder says, “the connectome is absolutely necessary and completely insufficient.”

Seung agrees but has never seen that as an argument for abandoning the enterprise. Science progresses when its practitioners find answers — this is the way of glory — but also when they make something that future generations rely on, even if they take it for granted. That, for Seung, would be more than good enough. “Necessary,” he said, “is still a pretty strong word, right?”

http://www.nytimes.com/2015/01/11/magazine/sebastian-seungs-quest-to-map-the-human-brain.html

https://eyewire.org/signup

#ScienceSunday  | +ScienceSunday 
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Met de overgang naar de gemeenten is de naam/term Bureau jeugdzorg verdwenen en bestaat vanaf nu niet meer. Maarde organisaties zelf bestaan nog zeker wel.Alle Bureaus Jeugdzorg hebben per vandaag 01-01-2015 hun nieuwe naam aangenomen, maar bli...
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These top-secret ninja moves will help you take control of your inbox and become a Gmail expert. I'll show you how to save time, avoid mistakes, and add a bit of style to your inbox. Read on, grasshopper....
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Rob Daalder

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Elder try to chromecast this
 
my blog will make you smile ♥
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my blog will make you smile ♥
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A multidisciplinary research team has discovered how cells know to rush to a wound and heal it -- opening the door to new treatments for diabetes, heart disease and cancer. The findings shed light on the mechanisms of cell migration, particularly in the wound-healing process. The results represent a major advancement for regenerative medicine, in which biomedical engineers and other researchers manipulate cells' form and function to create new ti...
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machine points to sew: :where applied mathematics?
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Parte del Tomaso Vitalino
is the title of a music manuscript that is kept in the State Library of Dresden, Germany. Thrilled by its score, the German virtuoso violinist and composer Ferdinand David (1810–1873) crafted an extensively revised edition of the piece and, probably due to the four-measure descending tetra chord, named it Chaconne. David published the Chaconne in G minor for violin and basso continuo in a collection called "Die Hoch Schule des Violinspiels", in 1867.

Research has reveiled that the abovementioned manuscript must have been copied by Jacob Lindner, the principal music scribe at the Dresden Hofkapelle in the period 1710–1728. Given that date period and its title, the original composition is commonly attributed to Tomaso Antonio Vitali (1663–1745), the eldest son ("Vitalino") of Giovanni Battista Vitali - like his father, Tomaso was a baroque composer and violinist from Bologna, Italy. However, since it doesn't compare with any of his other compositions nor can the piece be found in his catalogue of authenticated works, that attribution has been a source for many debates.

Despite its unclear origin, this impressive chamber work quickly thrilled other composers as well and different revisions followed soon. Léopold Charlier's 1911 arrangement, with enhanced technical demands of the violin part and significant improvements to the piano part, has become one of the most popular.
Today’s #sundayclassics contribution offers "Vitali's Chaconne" for concert stage. Have a romantic and passionate Sunday, dear plussers - enjoy :)

More examples:
1. Original manuscript from State Library
https://www.youtube.com/watch?v=oXWSlv1Gzn4 (Arthur Grumiaux)
2. Ferdinand David transcription
https://www.youtube.com/watch?v=mrn51WsyVOs (Salvatore Accardo)
3. Léopold Charlier arrangement
https://www.youtube.com/watch?v=0w3lkXanpOg (Henryk Szeryng)
or with orchestration
https://www.youtube.com/watch?v=BikbXFPoN28 (Zino Francescatti)

Related links:
http://en.wikipedia.org/wiki/Tomaso_Antonio_Vitali
http://en.wikipedia.org/wiki/Ferdinand_David_%28musician%29
http://imslp.org/wiki/Chaconne_(Vitali,_Tomaso_Antonio)
http://www.clariusaudi.com/attach/prefazioni/9790006001941_Innenansicht.pdf

o #sundayclassics #europeanmusic o
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........ ถ้าตราบใด ที่หัวใจไม่หยุดเต้น
ขออยู่เป็นคนคอยให้ใจห่วงหา
แม้ตัวไกลแต่หัวใจไม่ร้างลา
ด้วยศรัทธาแรงกล้าและคงมั่น
................มิตรภาพมีให้ไม่สลาย
ไม่เสื่อมคลายหายไปจากใจฉัน
แม้นปีเดือนเลื่อนไปนานนับวัน
ไม่ลืมกันสัมพันธ์ใจที่ให้เธอ
..................... อยู่วันนี้มีใจได้หวนคิด
แอบใกล้ชิดแนบใจให้เสมอ
เพียงบางวันใจอาจพลั้งเผลอ
เฝ้าละเมอถึงเธอทุกเวลา
...................ถึงจะเงียบหายไปในบางครั้ง ใจก็ยังเป็นหนึ่งไม่อ่อนล้า
เฝ้าติดตามถามข่าวอยู่เรื่อยมา
ถึงไกลตาแต่หัวใจ..ยัง...............””””ใกล้กัน”””








ขอบคุณ กลอนเพราะๆ ของคุนเพื่อน....เจ้าค่ะ...
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Have him in circles
218 people
BiologyCorner's profile photo
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Education
  • Delft University of Technology
    Industrial Design, 1970 - 1977
  • Delft University of Technology
    Physics, 1972 - 1977
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Complexity Scientist
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