Profile cover photo
Profile photo
Laurence A. “Larry” Moran
1,274 followers
1,274 followers
About
Laurence A.'s posts

Post has attachment
Debating alternative splicing (Part IV)
In Debating alternative splicing (Part III) I discussed a review published in the February 2017 issue of Trends in Biochemical Sciences . The review examined the data on detecting predicted protein isoforms and concluded that there was little evidence they ...

Post has attachment
Dedbating alternative splicing (Part IV)
In Debating alternative splicing (Part III) I discussed a review published in the February 2017 issue of Trends in Biochemical Sciences . The review examined the data on detecting predicted protein isoforms and concluded that there was little evidence they ...

Post has attachment
Debating alternative splicing (Part III)
Proponents of massive alternative splicing argue that most human genes produce many different protein isoforms. According to these scientists, this means that humans can make about 100,000 different proteins from only ~20,000 protein-coding genes. They tend...

Post has attachment
Debating alternative splicing (part II)
Mammalian genomes are very large. It looks like 90% of it is junk DNA. These genomes are pervasively transcribed, meaning that almost 90% of the bases are complementary to a transcript produced at some time during development. I think most of those transcri...

Post has attachment
Debating alternative splicing
I recently had a chance to talk science with my old friend and colleague Jack Greenblatt . He has recently teamed up with some of my other colleagues at the University of Toronto to publish a paper on alternative splicing in mouse cells. Over the years I ha...

Post has attachment
Are most transcription factor binding sites functional?
The ongoing debate over junk DNA often revolves around data collected by ENCODE and others. The idea that most of our genome is transcribed (pervasive transcription) seems to indicate that genes occupy most of the genome. The opposing view is that most of t...

Post has attachment
Jonathan Wells talks about junk DNA
Watch this video. It dates from this year. Almost everything Wells says is either false or misleading. Why? Is he incapable of learning about genomes, junk DNA, and evolutionary theory?

Post has attachment
Some of my former students
Some of my former students were able to come to my retirement reception yesterday: Sean Blaine (left), Anna Gagliardi, Marc Perry.

Post has attachment
Hot slash buns
I love hot "cross" buns but now we buy the atheist version.

Post has attachment
I retired after 39 years and they gave me an old used book
... but it was a rather special book ...
Wait while more posts are being loaded