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Creative Proteomics
141 followers -
Proteomics Services
Proteomics Services

141 followers
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If preclinical trials need to be carried out to evaluate pharmacokinetics, pharmacodynamics, ADME & toxicokinetics of the tested drug candidates to access drug safety and determine the safe dosage regiment for first-in-man study in corresponding animal models, which are chosen based on which would give the best correlation to human trials, but you have no certificated staff and facilities, you can commission the entire project to us, to obtain the critical parameters of the tested compounds, formulations and administration routes (oral, topical, inhalation and injection), in different animal models, which are important for regulated authorities.

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ADME and PK

Pharmacokinetics quantitatively how the body affects a specific #drug after administration through the mechanisms of absorption and distribution, as well as the #chemical changes of the substance in the body (e.g. by metabolic #enzymes such as cytochrome P450 or glucuronosyltransferase enzymes), and the effects and routes of excretion of the metabolites of the drug. Usually 4 steps are inovlved in the pharmacokinetics procedure:


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Which tank will fill up first? #genius ONLY
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Bioanalysis of Proteins

Equipped with advanced proteomics facilities, Creative Proteomics can provide bioanalytical support to our customers based on the Shotgun/Bottom-Up strategy, from simple amino acid analysis, identification of purified protein, protein/peptide sequencing, to characterization of the post-translational modifications, and protein-protein interactions.

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Bioactive small molecules, including important primary and secondary metabolites, collected from various tissues of different organisms, and exogenous drug & corresponding metabolites, often need to be indentified and quantified in different research fields. Most the time, the structures of specific small molecules need to be elucidated, and the abundance in different samples are often required to quantitatively analyzed, usually with the external standard method. In ordet to make it, the analytical facilities, such as Nuclear Magnetic Resonance Spectroscopy (NMR) and Mass Spectrometry (MS) are recommended for analysis of small molecules.

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Analysis of #Protein Glycation
As one of the chemical modifications, glycation, initially reported by Maillard, refers to the nonenzymatic reaction of sugars with proteins

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Characterization of #Protein #Biosimilar

A biosimilar, also known as follow-on biologic or subsequent entry #biologic, is a biologic medical product which is a modified copy of an original product. Biosimilars are officially approved versions of original products, and only allowed to manufacture when the original one's patent expires.

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Structure Activity Relationship (SAR) Analysis

currently employed in a wide range of applications, including: In-silico design of virtual #chemical libraries that explore #molecular diversity for subsequent #synthesis and screening; screening proprietary, commercially available, and public databases for lead discovery; and, mining gene expression data from microarray experiments for target identification.

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#Peptide Purity Analysis- measured by analytical reversed phase HPLC, is the percentage of the peptide compared to impurities that absorb at 210-220 nm(peptide bond absorption wavelength).

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The Boyden Chamber #assay, which is based on a chamber of two medium-filled compartment separated by a polycarbonate #membrane, is a widely accepted and useful #cell migration technology. It works like this. Generally speaking, cells are seeded in the upper compartment and allowed to migrate through the pores to the other side of the membrane into the lower compartment.
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