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Health Care On Air
Healthcare Professionals and Businesses Keeping the Public Informed.
Healthcare Professionals and Businesses Keeping the Public Informed.
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If you haven't realized yet, we changed our name
We will invite all followers and those in the community to the new website & page once completed

Thank you for all your patience and you will be hearing from us in the near future

#healthyliving   #healthcare   #healtylifestyle  

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Polymer Protects Mouse Heart
Mice injected with microscopic particles of plastic-like material gain protection from cardiac tissue damage after a heart attack. The harshest part of a heart attack isn’t always due to the stoppage of blood flow to the heart; rather it’s the immune system response to the damaged muscle tissue.
New research shows that the fore-mentioned plastic-like particles capable of blocking inflammation can protect mice from continued tissue damage, and even help strengthen cardiac function in the first month following a heart attack.
These heart-helping microscopic plastic-like particles are 500 nanometers and must be negatively charged. Note: there are several different materials that work, including polystyrene, microdiamonds, or biodegradable poly(lactic-co-glycolic) acid.
The particles interact with inflammatory monocytes in the bloodstream. This causes the particles to be directed to the spleen, where they undergo apoptosis (cell death), instead of returning to the heart.
The research team, including Daniel Getts, chief scientific officer of Cour Pharmaceutical Development and lead author on the study, suggest that such particles, termed immune-modifying microparticles (IMPs), may have a similar effect in humans. The team hopes to begin testing by early next year.
Source Article:
This study was published in Science Translational Medicine:  
Image: Heart Attack, Wikimedia Commons

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Smiles are contagious so go forth and contaminate as many people as you can!

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Are you feeding your body toxins?

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New American College of Rheumatology (ACR) guidelines for diagnosis and treatment of gout

As a #foot and ankle specialist, I am finding #gout to be an increasingly common problem I encounter among my patient population. I suspect it is associated with the increasing prevalence of metabolic syndrome and prediabetes. Given that gout is due to metabolic dysfunction, its increased prevalence is likely linked to the increasing numbers of patients with prediabetes-metabolic syndrome =>

A group of 12 national scientific committees, with input from 474 practicing rheumatologists developed 10 recommendations for the management of gout.

Here are the main points in a nutshell:

• Regarding a definitive diagnosis of gout - They advised that monosodium urate crystals be obtained if possible. However, the diagnosis also could be "supported" with imaging such as ultrasound and classical findings such as tophi or prompt response to colchicine therapy if aspiration proves difficult. Asymptomatic hyperuricemia without any other findings wasn't considered sufficient.

• Physicians should stress the importance of healthy lifestyle, including weight loss, exercise, and avoidance of alcohol and sugar-sweetened drinks.

• Regular evaluation of renal function, because kidney-related mortality has been reported as being increased fourfold in patients with gout.

• Assessing cardiovascular risk, as some evidence has suggested a link of gout with coronary heart disease. (If that’s the case, how about increased incident peripheral arterial disease?)

ACR recommendations addressing various aspects of treatment:

• For urate-lowering therapy - evidence for efficacy with allopurinol, febuxostat (Uloric), and pegloticase (Krystexxa), but "there was a strong consensus that allopurinol constitutes first-line urate-lowering therapy after consideration of its safety, efficacy, and cost." In most cases, therapy is started at low doses and gradually titrated to reach a target urate level, usually below 6 mg/dL, with an eventual goal of the elimination of tophi and no acute attacks.

• Combined xanthine oxidase inhibition and uricosuric treatment for refractory high urate levels.

• For acute gout flares – nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, and glucocorticoids. There wasn't enough evidence for one treatment over another. The decision is based on patients history and each drug's safety profile.

• Prophylaxis for acute flares in the initial period after urate-lowering therapy also should be considered. Colchicine in doses up to 1.2 mg per day can be used, or if contraindicated, alternatives are NSAIDs and low-dose corticosteroids.

• Most tophi can be managed medically, by reducing serum levels of urate below 5 mg/dL. Surgery should be reserved for special cases such as when there is nerve compression. (How about “shoe compression” or in the case of a chronic ulcerating tophus ?)

• They recommended against the pharmacologic treatment of asymptomatic hyperuricemia for prevention of gout or comorbidities. Asymptomatic hyperuricemia should be addressed with nonpharmacologic lifestyle changes.

Source article with link to full text .pdf of the guidelines: Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative =>

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Individual Treatments is key
The selection, dosing, and administration of anticancer agents and the management of associated toxicities are complex. Drug dose modifications and schedule and initiation of supportive care interventions are often necessary because of expected toxicities and because of individual patient variability, prior treatment, and comorbidities. Thus, the optimal delivery of anticancer agents requires a healthcare delivery team experienced in the use of such agents and the management of associated toxicities in patients with cancer. The cancer treatment regimens below may include both FDA-approved and unapproved uses/regimens and are provided as references only to the latest treatment strategies. Clinicians must choose and verify treatment options based on the individual patient.

#cancertreatment   #medicaltreatments   #cancer  

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TB skin tests are routine in the medical profession

Which will you prefer?
This patch with microneedles or the regular injection with a hypodermic needle?

Interesting towards the future of allergy testing with similar patches

#newscience   #medicalresearch   #tuberculosis  

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"Dental caries, pulpal caries, and chronic apical periodontitis are associated positively, while restorations are associated inversely, with aortic atherosclerotic burden."

#dentalhealth   #atherosclerosis  

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Exercise-Don't be a couch potato

#healthylifestyle   #exercise   #diseaseprevention  
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