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Barb Kueber
One Canadian changing the world.....Join me?
One Canadian changing the world.....Join me?
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SURGEON GENERAL’S WARNING
SURGEON GENERAL’S WARNING
barbkueber.wordpress.com

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SURGEON GENERAL’S WARNING
SURGEON GENERAL’S WARNING
barbkueber.wordpress.com

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“Preclinical data indicate that cannabis has powerful antioxidative, anti-inflammatory, and neuroprotective effects. Cannabis also has properties applicable to symptom management of ALS, including analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. With respect to the treatment of ALS, from both a disease modifying and symptom management viewpoint, clinical trials with cannabis are the next logical step. Based on the currently available scientific data, it is reasonable to think that cannabis might significantly slow the progression of ALS, potentially extending life expectancy and substantially reducing the overall burden of the disease.”[4] https://www.projectcbd.org/amyotrophic-lateral-sclerosis-als-and-cannabinoids

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“Preclinical data indicate that cannabis has powerful antioxidative, anti-inflammatory, and neuroprotective effects. Cannabis also has properties applicable to symptom management of ALS, including analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. With respect to the treatment of ALS, from both a disease modifying and symptom management viewpoint, clinical trials with cannabis are the next logical step. Based on the currently available scientific data, it is reasonable to think that cannabis might significantly slow the progression of ALS, potentially extending life expectancy and substantially reducing the overall burden of the disease.”[4] https://www.projectcbd.org/amyotrophic-lateral-sclerosis-als-and-cannabinoids

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Conclusion
In light of the above findings, there is a valid rationale to propose the use of cannabinoid compounds in the pharmacological management of ALS patients. Cannabinoids indeed are able to delay ALS progression and prolong survival. However, most of the studies that investigated the neuroprotective potential of these compounds in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. This remains the major challenge for the future and it may be facilitate by the recent approval of the first cannabinoid-based drug (Sativex®) available for clinical use. In the last years, a growing interest is focused on the combination drug approach with existing medications in order to maximize the therapeutic efficacy and minimize the adverse effects commonly observed with conventional therapies. We strongly hope to have provided a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids. We hope that our studies could be an alert to encourage the scientific community to further studies to confirm the therapeutic use of cannabinoids in this devastating disease.

Footnotes
Conflicts of interest: None declared.

Article information
Neural Regen Res. 2016 Dec; 11(12): 1896–1899.
doi: 10.4103/1673-5374.197125
PMCID: PMC5270417
PMID: 28197175
Sabrina Giacoppo and Emanuela Mazzon, Ph.D.* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/

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Conclusion
In light of the above findings, there is a valid rationale to propose the use of cannabinoid compounds in the pharmacological management of ALS patients. Cannabinoids indeed are able to delay ALS progression and prolong survival. However, most of the studies that investigated the neuroprotective potential of these compounds in ALS were performed in animal model, whereas the few clinical trials that investigated cannabinoids-based medicines were focused only on the alleviation of ALS-related symptoms, not on the control of disease progression. This remains the major challenge for the future and it may be facilitate by the recent approval of the first cannabinoid-based drug (Sativex®) available for clinical use. In the last years, a growing interest is focused on the combination drug approach with existing medications in order to maximize the therapeutic efficacy and minimize the adverse effects commonly observed with conventional therapies. We strongly hope to have provided a short but important overview of evidences that are useful to better characterize the efficacy as well as the molecular pathways modulated by cannabinoids. We hope that our studies could be an alert to encourage the scientific community to further studies to confirm the therapeutic use of cannabinoids in this devastating disease.

Footnotes
Conflicts of interest: None declared.

Article information
Neural Regen Res. 2016 Dec; 11(12): 1896–1899.
doi: 10.4103/1673-5374.197125
PMCID: PMC5270417
PMID: 28197175
Sabrina Giacoppo and Emanuela Mazzon, Ph.D.* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270417/

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Key documents in the Monsanto's RoundUp Cancer case

"Multi District Litigation: More than 425 lawsuits are pending against Monsanto Co. in U.S. District Court in San Francisco, filed by people alleging that exposure to Roundup herbicide caused them or their loved ones to develop non-Hodgkin lymphoma, and that Monsanto covered up the risks. The cases have been combined for handling as multidistrict litigation (MDL) under Judge Vince Chhabria. The lead case is 3:16-md-02741-VC.

Monsanto sought to have its internal records and communications sealed from public view but the judge has allowed many to be made part of the public record, and these “Monsanto Papers” are contained within the records below." https://usrtk.org/pesticides/mdl-monsanto-glyphosate-cancer-case-key-documents-analysis/

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Thank you Monsanto ( or is it Bayer now?), our lawyers are constantly looking for more job security and bigger troughs.

..."The Canadian Food Inspection Agency (CFIA) said Thursday the wheat containing a genetically modified trait, developed by Monsanto Co. to tolerate the Roundup weed killer, was discovered along an access road.

Unapproved GMO wheat found in southern Alberta, but risks mitigated, CFIA says

"We are suspending the tender and sale of Canadian wheat until we confirm that the Canadian wheat that Japan buys contains no GMO," the Japanese official said.

Canada is one of the world's largest wheat exporters. Japan is Canada's second largest global market for wheat, taking $598.6 million worth in 2016, according to the federal government's website.".... https://www.cbc.ca/news/canada/calgary/wheat-gmo-japan-genetically-modified-suspended-import-sale-1.4707563

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This makes perfect sense to me, I start scrolling my stream and it's sometimes seconds before what I see on FB makes me decide to simply close my browser. I would suggest, it's not only social media, it's that social media is bringing to light and constantly reminding us how shitty we, as society have allowed things to become, not just in our own countries.

..."Not only did smartphone use and depression increase in tandem, but time spent online was linked to mental health issues across two different data sets. We found that teens who spent five or more hours a day online were 71 percent more likely than those who spent less than an hour a day to have at least one suicide risk factor (depression, thinking about suicide, making a suicide plan or attempting suicide). Overall, suicide risk factors rose significantly after two or more hours a day of time online.

Of course, it’s possible that instead of time online causing depression, depression causes more time online. But three other studies show that is unlikely (at least, when viewed through social media use).

Two followed people over time, with both studies finding that spending more time on social media led to unhappiness, while unhappiness did not lead to more social media use. A third randomly assigned participants to give up Facebook for a week versus continuing their usual use. Those who avoided Facebook reported feeling less depressed at the end of the week."... https://theconversation.com/with-teen-mental-health-deteriorating-over-five-years-theres-a-likely-culprit-86996?utm_medium=amptwitter&utm_source=twitter

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..."One of the flaws of nutrition studies is that they rely on people to accurately recall what they’ve eaten over the course of a year. Those recollections are vulnerable to inaccuracy, especially for dairy fats which can be found in small amounts in many different foods. This inaccuracy may be one of the reasons studies have yielded contrary results on the link between milk and heart disease.

To improve estimates, Otto and Mozaffarian used a blood sample for each of more than 2,800 U.S. adults. Using the blood sample, they could detect how much dairy fats each had consumed. And over the eight-year follow up period, those who had consumed the most dairy fat were far less likely to develop heart disease compared to those who had consumed the least.

The advocates of whole milk allow that it has more calories than its low fat cousins, and for some, that might be reason to avoid it. But the traditional case against whole milk -- based on the risk of heart disease -- has frayed enough now that many argue the Dietary Guidelines should yield to the new findings.

“There is no scientific basis for current dietary advice regarding dairy,” Benatar said. “Fears [about whole milk] are not supported by evidence. The message that it is okay to have whole fat food, including whole fat milk, is slowly seeping into consciousness. But there is always a lag between evidence and changes in attitude.”...
- The Washington Post
- The Washington Post
washingtonpost.com
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