What do you want me to discuss at PyCon's keynote?

I'm starting to think about my annual PyCon keynote. I don't want it to be just a feel-good motivational speech (I'm no good at those), nor a dry "state of the Python union" talk (I'm bored with those), but I'd like to hear what Python users care about. Post your questions as comments here, or vote on others' questions using your +1 button.

If you don't have a G+ account, you can mail questions to guido@python.org-- I will then copy them here anonymously for voting, unless you ask me not to.
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