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JAMA

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Is bias with single-blind review greatest in a setting of author or institutional prestige? http://ja.ma/2cMddsW
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JAMA

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For more than 40 years, obesity prevention and treatment focused on reduction of dietary fat, consistent with the energy balance model of weight control. But this model, which considers all calories alike to the body, now faces challenge from the carbohydrate-insulin model and other approaches (eg, emphasizing macronutrient quality) that take into account the metabolic effects of food. http://ja.ma/2dD2Iux
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JAMA

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Alarmed by the scientific consensus that the Zika virus was behind a 20-fold spike in microcephaly cases reported last year in Brazil, investigators are anxious to see what befalls the new wave of mothers and infants. http://ja.ma/2cU6Zqz
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Kanu Okike, M.D., M.P.H., of the Kaiser Moanalua Medical Center, Honolulu, and colleagues examined if bias with single-blind peer review might be greatest in the setting of author or institutional prestige. http://ja.ma/2d7nGz6
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In an analysis that included nearly 1,300 patients with large-vessel ischemic stroke, earlier treatment with endovascular thrombectomy (intra-arterial use of a micro-catheter or other device to remove a blood clot) plus medical therapy (use of a clot dissolving agent) compared with medical therapy alone was associated with less disability at 3 months. http://ja.ma/2d7lDuO
Importance Endovascular thrombectomy with second-generation devices is beneficial for patients with ischemic stroke due to intracranial large-vessel occlusions. Delineation of the association of treatment time with outcomes would help to guide implementation. Objective To characterize the period in which endovascular thrombectomy is associated with benefit, ...
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Bundled payments for lower extremity joint replacement episodes may have the potential to decrease Medicare per-episode payments, while maintaining quality of care. http://ja.ma/2cU87dO
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Viewpoint by 2016 Lasker Award Winners William G. Kaelin, Peter J. Ratcliffe, and Gregg L. Semenza discusses their discovery of pathways by which humans and other multicellular organisms sense and respond to changes in oxygen availability. http://ja.ma/2cMdiwZ
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An investigational Zika vaccine developed by NIAID and the NIH enters phase 1 clinical trials. http://ja.ma/2dmal8N
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Marc S. Sabatine, M.D., M.P.H., of Brigham and Women's Hospital, Harvard Medical School, Boston, and colleagues evaluated the association between lowering low-density lipoprotein cholesterol (LDL-C) and relative cardiovascular risk reduction across different statin and nonstatin therapies. http://ja.ma/2dAfHxb
Importance The comparative clinical benefit of nonstatin therapies that reduce low-density lipoprotein cholesterol (LDL-C) remains uncertain. Objective To evaluate the association between lowering LDL-C and relative cardiovascular risk reduction across different statin and nonstatin therapies. Data Sources and Study Selection The ...
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New JAMA Issue—Zika, LDL-C Lowering and Cardiovascular Risk Reduction, + more! http://ja.ma/2cU7m4I
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