23andMe
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genetics just got personal
genetics just got personal
12,281 followers
23andMe's posts
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“I grew up as an only child, in a family that I was very different from,” said Rhonda. Read her 23andMe story on the blog: http://23me.co/WiTI3M
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B3:Brain Behavior, Business: You should share more of gene science with your customers. For example: ""Almost all living people outside of Africa trace back to a single migration more than 50,000 years ago". But you will get immediate aggressive, hostility from anti-science weirdos.
Breeze K: Hello I know I probably won't receive an answer here but I just purchased my ancestry/health kit last night. When I receive my results how will they be presented? My mother carries the BRCA2 Gene so I have a 50% chance of having it. As you know it's a pretty life changing diagnoses. Is there any way I can censor those results until I'm ready and or seeked genetic counseling ? Again I hope I'll receive a response and I wish you had a some form of help where you could ask questions. Thanks.
Vanna Gomez: I have a question.My sons father has no idea he has a son from me.I don't get ahold of him.He just went poof.I didn't know I was pregnant until I was 7 months.Can this DNA test tell me where he is?
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Just how similar are identical twins?
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Len Flom: Lutricia:
You and your twin have exactly the same genes (DNA)and that is called
"genotype "which is in your chromosomes not seen and is inside each of you
; however, what appears when both of you are born and is outside due to
the fact that all that genetic material does penetrate equally for each of
you.
That is referred to as incomplete genetic penetrance and is ,therefore,
your phenotype giving each of you different chacteristics such as different
freckles, fingerprints,etc.
In order for you to be as exactly as your sister the two of you would have
to be clones,and that is a whole other explanation.
Leonard Flom,M.D.
You and your twin have exactly the same genes (DNA)and that is called
"genotype "which is in your chromosomes not seen and is inside each of you
; however, what appears when both of you are born and is outside due to
the fact that all that genetic material does penetrate equally for each of
you.
That is referred to as incomplete genetic penetrance and is ,therefore,
your phenotype giving each of you different chacteristics such as different
freckles, fingerprints,etc.
In order for you to be as exactly as your sister the two of you would have
to be clones,and that is a whole other explanation.
Leonard Flom,M.D.
Lutricia Clifton: I'm an identical twin and assumed my sister would receive the same report as I. Explain Phenotypes and how it differs with identical twins.
Erica Gauger:
How can i get access to my profile?
How can i get access to my profile?
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“Science is solving puzzles.” – Sally Ride
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Valentina Sherren: I love the fact that Life has a million+ questions and tons of facts - and you're never too old to learn.
Moon Light: if the offspring gets half of the DNA from the father and the other half from the mother , so which half exactly or what's meant by half of DNA
if the mother give the "x" which is essential for life how could the other information on the male genes be compatible with the female to form a healthy offspring what are the chances
if the mother give the "x" which is essential for life how could the other information on the male genes be compatible with the female to form a healthy offspring what are the chances
Breeze K: Hello I know I probably won't receive an answer here but I just purchased my ancestry/health kit last night. When I receive my results how will they be presented? My mother carries the BRCA2 Gene so I have a 50% chance of having it. As you know it's a pretty life changing diagnoses. Is there any way I can censor those results until I'm ready and or seeked genetic counseling ? Again I hope I'll receive a response and I wish you had a some form of help where you could ask questions. Thanks.
Post has attachment
What will women learn from 23andMe? http://23me.co/YqNpG8
23andMe FAQ: What can women learn from 23andMe?
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Adele Peterson: I use my cell phone for Internet. I registered my mothers kit to a gmail account of mine and my kit to a yahoo account of mine. When I answer questions you are putting them together like it's one account instead of two. When I tried to link the accounts it said I couldn't send a request to myself? Third time I have vented!!! I'm ready to ask for my money back!
Marg Whitfield: You sent me an email saying my sample was missed placed that he would send me another one but you haven't what's going on?
Joan Girdler: I sent my brother's saliva in and got a report and since have answered several test questions to help science, yet you keep sending ads as if I had not been tested. I called several months ago to see if I could send in my own saliva and got a woman who was not in the least helpful. Why are you not interested in more business? I am baffled as I was pleased with my first report, yet the lady with whom I spoke couldn't have been more disinterested or unhelpful. -Infact she was very rude. Plse respond as to whether or not sending in my saliva would be helpful.
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Public
Do you love or hate the “devil’s herb”?
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Steven Specht: My bride and I both dislike the soap flavor.
Rhonda-Lynn Robson Heafey: It's true...both my daughter and myself think cilantro tasted like dish washing detergent, Yuck!
GAVDish: Pico de Gallo, Mandarin and Jicama Salad, Green Rice ... you gotta have cilantro 😊 the perfume of cilantro is part of the flavor.
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Public
“What is research but a blind date with knowledge?” – William Henry
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Jason Evan Baldwin: Check out this great article I read on WIRED:
A WIRED Classic about Segey Brin's new approach to solving an old problem: collect data, then hypothesize, then find patterns that lead to answers.
https://www.wired.com/2010/06/ff_sergeys_search/?mbid=email_onsiteshare
Happy's formula for parkinson's includs Vitemin E oil, Nutmeg Oil and Bamboo Carbon...
See why below...
There are relatively few causes of hormone overproduction...
overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone.
-----
Neuron Protector and Tumor Suppressor.
In the 1980s researchers began reporting that Parkinson's patients had an overall decreased incidence of cancer, with some important exceptions, mainly melanoma.
https://academic.oup.com/jnci/article/102/6/371/952756/Parkinson-s-Disease-and-Cancer-The-Unexplored
Melanomas often resemble moles; some develop from moles. ... While it is not the most common of the skin cancers, it causes the most deaths.
CONNECTIONS?, overproduction (cancer) and underproduction (parkinson's)
"Parkinson's Disease and Cancer: The Unexplored Connection"
Mr Happy cured my sciatica in 3 weeks with "megadoses of vitamin E".
After 3 years of increasing stiffness and back pain that started in my lower back and continued down to the back of my knee as nerv pain. I researched everything about sciatica but the few options were surgical and some had BAD results.
So after I had already excepted the fact that I would be living with a sciatica problem
and be in pain for the rest of my life. I was saved....
A STUDENT FROM SAINT GEORGES UNIVERSITY HAD A EXPLANATION
OF THE CAUSE AND A POSSIBLE CURE WITCH HAS YET TO BE PUT INTO PRATICE
(BECAUSE HE WAS A NEW STUDENT AND THIS WAS NOT ALLOWED).
This Guy (I call him Happy) is amazing but the School's system is holding him back.
(He should be teaching them, Not the other way around) Did Einstien need a degree
in something only he understood, And 100 years later we still don't ?.
My back problem was not atherosclerosis as bad as to lead to Parkinson's
But Mr Happy could see the logic in it (And lot's more than that).
Happy see's more than what's in the books, but Medical school's have stupid rules...
Happy explains thing's to me in a way that even I understand. And I'm just a Sailor
The wikipedia artical below explains what he saw a little better...
"In 1945, Drs. Evan V. Shute and Wilfred E. Shute, siblings from Ontario, Canada, published the first monograph arguing that megadoses of vitamin E can slow down and even reverse the development of atherosclerosis".
The first use for vitamin E as a therapeutic agent was conducted in 1938 by Widenbauer, who used wheat germ oil supplement on 17 premature newborn infants suffering from growth failure. Eleven of the original 17 patients recovered and were able to resume normal growth rates.
https://en.wikipedia.org/wiki/Vitamin_E
Parkinson's Syndrome Sufferers may present with various combinations of back, buttock and leg pain, numbness and muscle weakness.
Parkinson’s Syndrome is a condition where the important nuclei below the brain become dysfunctional resulting in impaired communication and transmission of nerve impulses to and from nerve fibres throughout the body.
The gait deteriorates as seem as a shuffling pattern with small steps with a quickening of gait as power is mustered and spasm is overcome, Whilst there is a downhill trend the process of deterioration may arrest for periods.
Seldom does this process directly generate nerve pain such as sciatica. Back or Neck pain and pain referred in to the arm (Brachialgia) or leg (Sciatica) may arise in Parkinson’s Syndrome Sufferers as part of the Degenerative Disc Disease seen in the rest of the population and with the same pathologies
http://www.spinal-foundation.org/conditions/parkinsons-disease-sufferers
"Please help Happy WITH FUNDING or something TO CONFIRM HIS FINDINGS"...
And take his research skills where it's needed.
In my eyes, He is a pioneer waiting to be disscovered and it's sad that so far I one of few who understand's his work and knows what he can do....
Vitamin E has been linked to lower risk of PD
Vitamin E can combat the damage caused by so called "free radicals", and high dietary intake of vitamin E has been linked to lower risk of PD. Unfortunately, optimism over its use in PD has not been confirmed.
---
SOME KNOWN FACTS.
Parkinson's Disease and Cancer: The Unexplored Connection
https://academic.oup.com/jnci/article/102/6/371/952756/Parkinson-s-Disease-and-Cancer-The-Unexplored
---
Hormones found to affect gene activity
https://phys.org/news/2009-08-hormones-affect-gene.html
---
The release of hormones by the body's glands can occur in an episodic, or ultradian, pattern, which consists of repeated periods of release that take place throughout a 24-hour, or circadian, period. Glucocorticoid hormones, which were investigated in this study, are steroid hormones secreted by the adrenal glands that are involved in a large variety of animal and human physiological responses.
"Studies of the glucocorticoid receptor typically assess gene responses after long-term stimulation with synthetic hormones. However, such treatments may not fully replicate the actual situation in living animals."
In this new study, the researchers demonstrate that ultradian hormone stimulation induces the pulsed expression of genes (known as gene pulsing) over the same period, both in cultured cells and in animal models.
The researchers conclude that, considering the wide therapeutic use of glucocorticoids for arthritis and even some cancer indications, further studies to replicate their results and follow-up studies in humans are clearly needed. Such studies will help to define the potential role of ultradian application of glucocorticoid receptor therapy.
Read more at: https://phys.org/news/2009-08-hormones-affect-gene.html#jCp
---
ultradian hormone stimulation
Vitamins A and E are the most light-sensitive vitamins. Vitamin A is degraded by photolysis, while vitamin E degrades by photo-oxidation. The composition of the parenteral nutrition mixture and the container could therefore influence degradation during daylight administration.
https://www.ncbi.nlm.nih.gov/pubmed/11031072
Examples of free-running rhythms of sleep-wake and food-intake behavior by various authors are strong indicators of the endogenous nature of the circadian rhythms in infants and show that the internal clock is already functioning at birth. It is still uncertain when the process of synchronization to external and social time cues begins and how differences in the maturation of perceptive organs affect the importance of time cues for the entrainment.
https://www.ncbi.nlm.nih.gov/pubmed/10219486
Vitamins A and E are the most light-sensitive vitamins.
"Vitamin A also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells".
https://en.wikipedia.org/wiki/Vitamin_A
---
INTRO...
All endocrine disease stems from either an overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone-secreting endocrine gland. There are relatively few causes of hormone overproduction. In general, overproduction results from hyperplasia, an increase in the number of cells (in this case, hormone-secreting cells) in a specific endocrine gland.
---
Parkinson's Disease and The Endocrine System.
The Endocrine System is made up of various glands, which leads to what the system's job is. The main function is to release hormones to the body.
Parkinson's Disease is considered as one of the diseases that interrupt with the Endocrine System, it is known as an Endocrine Disrupter. Once you get this disease you will go through a lot of different kinds of stress, and especially emotional stress. This will definitely relate to the hormonal glands. To help the person feel better, there is medication available, this will also prevent drastic mood swings that they will go through.
http://aboutparkinsonsdisease.weebly.com/endocrine-system.html
-
The principal molecular mechanisms that control the process and sequence of myelinogenesis are not entirely known. Numerous studies have primarily focused on simplifying the underlying neuronal control of myelinogenesis and such studies have provided several possibilities.
Although the mechanisms and processes of myelination are yet to be fully understood, some specific stages in this process have become clear:
Stage 1: Axon contact
Stage 2: Glial cell gene production
Stage 3: Axon ensheathment, which is one of two phases in the early stages of the formation of myelin sheath. Spiral ensheathment of target axons begins through the elaboration from each initiator process of lamellar extensions which extend circumferentially around the target axon and thereby form the first turn of its myelin sheath.[4]
Stage 4: Maturation
One early study focused on the signaling of oligodendrocyte myelination by regenerating peripheral axons. Researchers studied regenerating PNS axons for 28 weeks in order to investigate whether or not peripheral axons stimulate oligodendrocytes to begin myelination.
Oligodendrocytes are responsible for the creation of myelin sheaths in the central nervous system, whilst Schwann Cells are responsible in the peripheral nervous system. There are “two stages of OL markers, differentiation of OPCs to OLs, and ensheathment of axons…”
The myelination process allows neuronal signals to propagate down an axon more swiftly without the loss of signal. This enables better connectivity within specific brain regions and also improves broader neuronal pathways connecting spatially separate regions required for many sensory, cognitive, and motor functions.
On a cellular level, the study experimentally demonstrated that OLIG1 is necessary in order to stimulate myelination by oligodendrocytes in the brain. However, spinal cord related oligodendrocytes demonstrated a significantly smaller need of OLIG1 regulation in order to begin myelination.
Recent research in rats has suggested that the separate action of apotransferrin and thyroid hormone could have an important role in myelination. Moreover, research also seems to indicate that the function of transferrin and thyroid hormone together act to control myelinogenesis.
Primarily, this research indicated that due to hyperthyroidism that resulted from an increase in transferrin expression, as well as apotransferrin-dependent regulation of thyroid hormone receptor alpha, meant that transferrin was likely related to thyroid hormone’s effects on oligodendrocyte maturation, and eventually myelination.
The relationship is believed to take place at the thyroid hormone receptor level. Immunohistochemistry analysis was utilized in order to further confirm the relationship between thyroid hormone and apotransferrin during oligodendrogenesis.
The thyroid hormones act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis ?(synthesis vs production ?) , help regulate long bone growth (synergy with growth hormone) and neural maturation, and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.
The thyroid hormones are essential to proper development and differentiation of all cells of the human body.
These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
They ? also stimulate vitamin metabolism. ??? (Thyroid hormone or thyronamines ?).
"However, the thyronamines function via some unknown mechanism to inhibit neuronal activity. One effect of administering the thyronamines is a severe drop in body temperature."
(Thyroid hormone vs thyronamines )
Numerous physiological and pathological stimuli influence thyroid hormone synthesis. Thyroid hormone leads to heat generation in humans.
pathological and stimuli
A physiological disease is a disease in which the organs or the systems in the body malfunction causing illnesses. Some examples are asthma, hypertension...
ORGANIC vs SYNTHESIZED...= BAD
"Food or beverage composition fortified with thyronamines and/or thyronamine precursors"
trace amines = BAD
Dopamine, noradrenaline, and serotonin, the trace amines have been implicated in a vast array of human disorders of affect and cognition, such as ADHD, depression and schizophrenia, among others.
Trace aminergic hypo-function ??? (Trace aminergic "OR" hypo-function).
Trace aminergic hypo-function is particularly relevant to ADHD, since urinary and plasma phenethylamine concentrations are significantly lower in ADHD individuals relative to controls and the two most commonly prescribed drugs for ADHD, amphetamine and methylphenidate, increase phenethylamine biosynthesis in treatment-responsive individuals with ADHD.
Peptide hormones are synthesized in endoplasmic reticulum, transferred to the Golgi and packaged into secretory vesicles for export. They can be secreted by one of two pathways: Regulated secretion: The cell stores hormone in secretory granules and releases them in "bursts" when stimulated.
synthesis vs production
Metabolism or metabolic processes ?
Metabolism is a biochemical process that allows an organism to live, grow, reproduce, heal, and adapt to its environment.
Anabolism and catabolism are two metabolic processes, or phases. Anabolism refers to the process which builds molecules the body needs??? (NEEDS? MOLECULES?); it usually requires energy for completion.
- NOTE---
Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).
--END NOTE--
NUTRITION ?.
enzyme-catalyzed reactions = GOOD.
The three main purposes of metabolism are the conversion of food/fuel to energy to
run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes.
These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments.
"Catalysts lower the activation energy for reactions. The lower the activation energy for a reaction, the faster the rate. Thus enzymes speed up reactions by lowering activation energy. Many enzymes change shape when substrates bind."
MISSING LINKS LIST....
hypo-function.
in human endocrine system: Endocrine hypofunction and receptor defects
"In some cases, a decrease in hormone production, known as hypofunction, is required to maintain homeostasis". One example of hypofunction is decreased production of thyroid hormones during starvation and illness. Because the thyroid hormones control energy expenditure, there is survival value in slowing the body’s metabolism when food intake is low. Thus, there is a distinction between...
Read More
causes of endocrine diseases
The routine monitoring of blood pressure levels is an important part of assessing an individual’s health. Blood pressure provides information about the amount of blood in circulation and about heart function and thus is an important indicator of disease.
in human disease: Diseases of metabolic-endocrine origin
All endocrine disease stems from either an overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone-secreting endocrine gland. There are relatively few causes of hormone overproduction. In general, overproduction results from hyperplasia, an increase in the number of cells (in this case, hormone-secreting cells) in a specific endocrine gland. It can also be caused by...
Read More
https://www.britannica.com/science/hypofunction
PHOTOTROPH
classification of bacteria
in bacteria: Nutritional requirements
...is almost always obtained by the transfer of an electron from an electron donor to an electron acceptor. There are three basic sources of energy: light, inorganic compounds, and organic compounds. Phototrophic bacteria use photosynthesis to generate cellular energy in the form of adenosine triphosphate (ATP) from light energy. Chemotrophs obtain their energy from chemicals (organic and...
Read More
evolution of protozoans
A species of dinoflagellate known as Noctiluca scintillans, commonly called sea sparkle, is a type of algae that can aggregate into an algal bloom, producing substances that are potentially toxic to marine life.
in protozoan: Evolution and paleontology
...evolved different ways of life, and their structures became modified accordingly. As phagotrophs that ingested bacteria for food, they in some cases came to establish symbiotic associations with photosynthetic species, and ultimately the endosymbionts became plastids within the cell.
Read More
https://www.britannica.com/science/phototroph
---
MORE NOTES
Vitamin E therapy in Parkinson's disease.
Though the etiology is not well understood, late-onset Parkinson's disease (PD) appears to result from several key factors including exposure to unknown environmental toxicants, toxic endogenous compounds and genetic alterations. A plethora of scientific evidence suggest that these environmental and endogenous factors cause PD by producing mitochondrial (mito) oxidative stress and damage in the substantia nigra, leading to cell death.
ncbi.nlm.nih.gov - Vitamin E therapy in Parkinson's disease. - PubMed - NCBI
Happy's formula for Parkinson’s includes Vitamin E oil, Nutmeg Oil and Bamboo Carbon...
Try it .....
A WIRED Classic about Segey Brin's new approach to solving an old problem: collect data, then hypothesize, then find patterns that lead to answers.
https://www.wired.com/2010/06/ff_sergeys_search/?mbid=email_onsiteshare
Happy's formula for parkinson's includs Vitemin E oil, Nutmeg Oil and Bamboo Carbon...
See why below...
There are relatively few causes of hormone overproduction...
overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone.
-----
Neuron Protector and Tumor Suppressor.
In the 1980s researchers began reporting that Parkinson's patients had an overall decreased incidence of cancer, with some important exceptions, mainly melanoma.
https://academic.oup.com/jnci/article/102/6/371/952756/Parkinson-s-Disease-and-Cancer-The-Unexplored
Melanomas often resemble moles; some develop from moles. ... While it is not the most common of the skin cancers, it causes the most deaths.
CONNECTIONS?, overproduction (cancer) and underproduction (parkinson's)
"Parkinson's Disease and Cancer: The Unexplored Connection"
Mr Happy cured my sciatica in 3 weeks with "megadoses of vitamin E".
After 3 years of increasing stiffness and back pain that started in my lower back and continued down to the back of my knee as nerv pain. I researched everything about sciatica but the few options were surgical and some had BAD results.
So after I had already excepted the fact that I would be living with a sciatica problem
and be in pain for the rest of my life. I was saved....
A STUDENT FROM SAINT GEORGES UNIVERSITY HAD A EXPLANATION
OF THE CAUSE AND A POSSIBLE CURE WITCH HAS YET TO BE PUT INTO PRATICE
(BECAUSE HE WAS A NEW STUDENT AND THIS WAS NOT ALLOWED).
This Guy (I call him Happy) is amazing but the School's system is holding him back.
(He should be teaching them, Not the other way around) Did Einstien need a degree
in something only he understood, And 100 years later we still don't ?.
My back problem was not atherosclerosis as bad as to lead to Parkinson's
But Mr Happy could see the logic in it (And lot's more than that).
Happy see's more than what's in the books, but Medical school's have stupid rules...
Happy explains thing's to me in a way that even I understand. And I'm just a Sailor
The wikipedia artical below explains what he saw a little better...
"In 1945, Drs. Evan V. Shute and Wilfred E. Shute, siblings from Ontario, Canada, published the first monograph arguing that megadoses of vitamin E can slow down and even reverse the development of atherosclerosis".
The first use for vitamin E as a therapeutic agent was conducted in 1938 by Widenbauer, who used wheat germ oil supplement on 17 premature newborn infants suffering from growth failure. Eleven of the original 17 patients recovered and were able to resume normal growth rates.
https://en.wikipedia.org/wiki/Vitamin_E
Parkinson's Syndrome Sufferers may present with various combinations of back, buttock and leg pain, numbness and muscle weakness.
Parkinson’s Syndrome is a condition where the important nuclei below the brain become dysfunctional resulting in impaired communication and transmission of nerve impulses to and from nerve fibres throughout the body.
The gait deteriorates as seem as a shuffling pattern with small steps with a quickening of gait as power is mustered and spasm is overcome, Whilst there is a downhill trend the process of deterioration may arrest for periods.
Seldom does this process directly generate nerve pain such as sciatica. Back or Neck pain and pain referred in to the arm (Brachialgia) or leg (Sciatica) may arise in Parkinson’s Syndrome Sufferers as part of the Degenerative Disc Disease seen in the rest of the population and with the same pathologies
http://www.spinal-foundation.org/conditions/parkinsons-disease-sufferers
"Please help Happy WITH FUNDING or something TO CONFIRM HIS FINDINGS"...
And take his research skills where it's needed.
In my eyes, He is a pioneer waiting to be disscovered and it's sad that so far I one of few who understand's his work and knows what he can do....
Vitamin E has been linked to lower risk of PD
Vitamin E can combat the damage caused by so called "free radicals", and high dietary intake of vitamin E has been linked to lower risk of PD. Unfortunately, optimism over its use in PD has not been confirmed.
SOME KNOWN FACTS.
Parkinson's Disease and Cancer: The Unexplored Connection
https://academic.oup.com/jnci/article/102/6/371/952756/Parkinson-s-Disease-and-Cancer-The-Unexplored
Hormones found to affect gene activity
https://phys.org/news/2009-08-hormones-affect-gene.html
The release of hormones by the body's glands can occur in an episodic, or ultradian, pattern, which consists of repeated periods of release that take place throughout a 24-hour, or circadian, period. Glucocorticoid hormones, which were investigated in this study, are steroid hormones secreted by the adrenal glands that are involved in a large variety of animal and human physiological responses.
"Studies of the glucocorticoid receptor typically assess gene responses after long-term stimulation with synthetic hormones. However, such treatments may not fully replicate the actual situation in living animals."
In this new study, the researchers demonstrate that ultradian hormone stimulation induces the pulsed expression of genes (known as gene pulsing) over the same period, both in cultured cells and in animal models.
The researchers conclude that, considering the wide therapeutic use of glucocorticoids for arthritis and even some cancer indications, further studies to replicate their results and follow-up studies in humans are clearly needed. Such studies will help to define the potential role of ultradian application of glucocorticoid receptor therapy.
Read more at: https://phys.org/news/2009-08-hormones-affect-gene.html#jCp
ultradian hormone stimulation
Vitamins A and E are the most light-sensitive vitamins. Vitamin A is degraded by photolysis, while vitamin E degrades by photo-oxidation. The composition of the parenteral nutrition mixture and the container could therefore influence degradation during daylight administration.
https://www.ncbi.nlm.nih.gov/pubmed/11031072
Examples of free-running rhythms of sleep-wake and food-intake behavior by various authors are strong indicators of the endogenous nature of the circadian rhythms in infants and show that the internal clock is already functioning at birth. It is still uncertain when the process of synchronization to external and social time cues begins and how differences in the maturation of perceptive organs affect the importance of time cues for the entrainment.
https://www.ncbi.nlm.nih.gov/pubmed/10219486
Vitamins A and E are the most light-sensitive vitamins.
"Vitamin A also functions in a very different role as retinoic acid (an irreversibly oxidized form of retinol), which is an important hormone-like growth factor for epithelial and other cells".
https://en.wikipedia.org/wiki/Vitamin_A
INTRO...
All endocrine disease stems from either an overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone-secreting endocrine gland. There are relatively few causes of hormone overproduction. In general, overproduction results from hyperplasia, an increase in the number of cells (in this case, hormone-secreting cells) in a specific endocrine gland.
Parkinson's Disease and The Endocrine System.
The Endocrine System is made up of various glands, which leads to what the system's job is. The main function is to release hormones to the body.
Parkinson's Disease is considered as one of the diseases that interrupt with the Endocrine System, it is known as an Endocrine Disrupter. Once you get this disease you will go through a lot of different kinds of stress, and especially emotional stress. This will definitely relate to the hormonal glands. To help the person feel better, there is medication available, this will also prevent drastic mood swings that they will go through.
http://aboutparkinsonsdisease.weebly.com/endocrine-system.html
The principal molecular mechanisms that control the process and sequence of myelinogenesis are not entirely known. Numerous studies have primarily focused on simplifying the underlying neuronal control of myelinogenesis and such studies have provided several possibilities.
Although the mechanisms and processes of myelination are yet to be fully understood, some specific stages in this process have become clear:
Stage 1: Axon contact
Stage 2: Glial cell gene production
Stage 3: Axon ensheathment, which is one of two phases in the early stages of the formation of myelin sheath. Spiral ensheathment of target axons begins through the elaboration from each initiator process of lamellar extensions which extend circumferentially around the target axon and thereby form the first turn of its myelin sheath.[4]
Stage 4: Maturation
One early study focused on the signaling of oligodendrocyte myelination by regenerating peripheral axons. Researchers studied regenerating PNS axons for 28 weeks in order to investigate whether or not peripheral axons stimulate oligodendrocytes to begin myelination.
Oligodendrocytes are responsible for the creation of myelin sheaths in the central nervous system, whilst Schwann Cells are responsible in the peripheral nervous system. There are “two stages of OL markers, differentiation of OPCs to OLs, and ensheathment of axons…”
The myelination process allows neuronal signals to propagate down an axon more swiftly without the loss of signal. This enables better connectivity within specific brain regions and also improves broader neuronal pathways connecting spatially separate regions required for many sensory, cognitive, and motor functions.
On a cellular level, the study experimentally demonstrated that OLIG1 is necessary in order to stimulate myelination by oligodendrocytes in the brain. However, spinal cord related oligodendrocytes demonstrated a significantly smaller need of OLIG1 regulation in order to begin myelination.
Recent research in rats has suggested that the separate action of apotransferrin and thyroid hormone could have an important role in myelination. Moreover, research also seems to indicate that the function of transferrin and thyroid hormone together act to control myelinogenesis.
Primarily, this research indicated that due to hyperthyroidism that resulted from an increase in transferrin expression, as well as apotransferrin-dependent regulation of thyroid hormone receptor alpha, meant that transferrin was likely related to thyroid hormone’s effects on oligodendrocyte maturation, and eventually myelination.
The relationship is believed to take place at the thyroid hormone receptor level. Immunohistochemistry analysis was utilized in order to further confirm the relationship between thyroid hormone and apotransferrin during oligodendrogenesis.
The thyroid hormones act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis ?(synthesis vs production ?) , help regulate long bone growth (synergy with growth hormone) and neural maturation, and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.
The thyroid hormones are essential to proper development and differentiation of all cells of the human body.
These hormones also regulate protein, fat, and carbohydrate metabolism, affecting how human cells use energetic compounds.
They ? also stimulate vitamin metabolism. ??? (Thyroid hormone or thyronamines ?).
"However, the thyronamines function via some unknown mechanism to inhibit neuronal activity. One effect of administering the thyronamines is a severe drop in body temperature."
(Thyroid hormone vs thyronamines )
Numerous physiological and pathological stimuli influence thyroid hormone synthesis. Thyroid hormone leads to heat generation in humans.
pathological and stimuli
A physiological disease is a disease in which the organs or the systems in the body malfunction causing illnesses. Some examples are asthma, hypertension...
ORGANIC vs SYNTHESIZED...= BAD
"Food or beverage composition fortified with thyronamines and/or thyronamine precursors"
trace amines = BAD
Dopamine, noradrenaline, and serotonin, the trace amines have been implicated in a vast array of human disorders of affect and cognition, such as ADHD, depression and schizophrenia, among others.
Trace aminergic hypo-function ??? (Trace aminergic "OR" hypo-function).
Trace aminergic hypo-function is particularly relevant to ADHD, since urinary and plasma phenethylamine concentrations are significantly lower in ADHD individuals relative to controls and the two most commonly prescribed drugs for ADHD, amphetamine and methylphenidate, increase phenethylamine biosynthesis in treatment-responsive individuals with ADHD.
Peptide hormones are synthesized in endoplasmic reticulum, transferred to the Golgi and packaged into secretory vesicles for export. They can be secreted by one of two pathways: Regulated secretion: The cell stores hormone in secretory granules and releases them in "bursts" when stimulated.
synthesis vs production
Metabolism or metabolic processes ?
Metabolism is a biochemical process that allows an organism to live, grow, reproduce, heal, and adapt to its environment.
Anabolism and catabolism are two metabolic processes, or phases. Anabolism refers to the process which builds molecules the body needs??? (NEEDS? MOLECULES?); it usually requires energy for completion.
Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).
NUTRITION ?.
enzyme-catalyzed reactions = GOOD.
The three main purposes of metabolism are the conversion of food/fuel to energy to
run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes.
These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments.
"Catalysts lower the activation energy for reactions. The lower the activation energy for a reaction, the faster the rate. Thus enzymes speed up reactions by lowering activation energy. Many enzymes change shape when substrates bind."
MISSING LINKS LIST....
hypo-function.
in human endocrine system: Endocrine hypofunction and receptor defects
"In some cases, a decrease in hormone production, known as hypofunction, is required to maintain homeostasis". One example of hypofunction is decreased production of thyroid hormones during starvation and illness. Because the thyroid hormones control energy expenditure, there is survival value in slowing the body’s metabolism when food intake is low. Thus, there is a distinction between...
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causes of endocrine diseases
The routine monitoring of blood pressure levels is an important part of assessing an individual’s health. Blood pressure provides information about the amount of blood in circulation and about heart function and thus is an important indicator of disease.
in human disease: Diseases of metabolic-endocrine origin
All endocrine disease stems from either an overproduction (hyperfunction) or underproduction ( hypofunction) of some hormone-secreting endocrine gland. There are relatively few causes of hormone overproduction. In general, overproduction results from hyperplasia, an increase in the number of cells (in this case, hormone-secreting cells) in a specific endocrine gland. It can also be caused by...
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https://www.britannica.com/science/hypofunction
PHOTOTROPH
classification of bacteria
in bacteria: Nutritional requirements
...is almost always obtained by the transfer of an electron from an electron donor to an electron acceptor. There are three basic sources of energy: light, inorganic compounds, and organic compounds. Phototrophic bacteria use photosynthesis to generate cellular energy in the form of adenosine triphosphate (ATP) from light energy. Chemotrophs obtain their energy from chemicals (organic and...
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evolution of protozoans
A species of dinoflagellate known as Noctiluca scintillans, commonly called sea sparkle, is a type of algae that can aggregate into an algal bloom, producing substances that are potentially toxic to marine life.
in protozoan: Evolution and paleontology
...evolved different ways of life, and their structures became modified accordingly. As phagotrophs that ingested bacteria for food, they in some cases came to establish symbiotic associations with photosynthetic species, and ultimately the endosymbionts became plastids within the cell.
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https://www.britannica.com/science/phototroph
MORE NOTES
Vitamin E therapy in Parkinson's disease.
Though the etiology is not well understood, late-onset Parkinson's disease (PD) appears to result from several key factors including exposure to unknown environmental toxicants, toxic endogenous compounds and genetic alterations. A plethora of scientific evidence suggest that these environmental and endogenous factors cause PD by producing mitochondrial (mito) oxidative stress and damage in the substantia nigra, leading to cell death.
ncbi.nlm.nih.gov - Vitamin E therapy in Parkinson's disease. - PubMed - NCBI
Happy's formula for Parkinson’s includes Vitamin E oil, Nutmeg Oil and Bamboo Carbon...
Try it .....
John Lund: You seem to have lost my DNA results. My analysis was done before the FEDS inserted themselves into our business. What now? Thanks.
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ACHOO syndrome may be associated with a genetic variant. Do you sneeze when you look at the bright sun?
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Marlene Upp: I sneeze in the sunlight! If I feel like I need to sneeze I will look up to a light. My Nana taught me that when I was very young. I still do it and it works.
Fiorella Caruso: woww! i didn't know this one is actually a 'syndrome'.😂 i suffer from this😅, everytime i expose myself to the sun i sneeze about 2/3 times at least. & even if then i catch a shadow... when i get back to sun just happens 😅😅😅
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“An investment in knowledge pays the best interest.” – Benjamin Franklin
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Valentina Sherren: Benjamin Franklin is quite quotable - and has a brilliant way with words - can't remember his quotes, but I know I enjoyed them!
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What does it mean to be twins? What does it mean to be identical? http://23me.co/6OhXyA
23andMe Story: Two of a Kind, Erika and Kristin
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What traits do you get from your Neanderthal cousins? http://23me.co/ped8XC
23andMe FAQ: What is Neanderthal DNA?
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Valentina Sherren: No idea, but I'm very lucky - I found out that I'm 3% Neanderthal - which has nothing to do with Jerili Chance's post his/her missing sample - hope it turns up for him/her.
jerili chance: I followed the rules , paid the fee , spit into the container and mailed it in. This was at least 3 weeks ago but so far have heard nothing.
Jerili Chance
Jerili Chance
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