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Nikolai Slavov
223 followers -
I love science !
I love science !

223 followers
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Transformative opportunities for improving the quantification of proteins in single cells.
https://peerj.com/preprints/26821/
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The biggest challenge is coming up with a creative conceptual idea. This is well illustrated with the development of Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS). SCoPE-MS could have been developed seven years ago if a PI had the idea for it; in fact, we developed SCoPE-MS using only technology that was already present in 2010, and awaited the idea that would enable single-cell proteomics by mass-spectrometry. Now that the idea had been demonstrated, the major mass-spectrometry labs around the world are actively building upon it, using the latest technologies. What was rate limiting was the idea – not the technology.


http://www.frontlinegenomics.com/interview/14892/short-read-nikolai-slavov-festival-of-genomics/

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Nikolai Slavov
Nikolai Slavov
singlecellbiology.wordpress.com

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I love the simplicity and power of this model http://www.biorxiv.org/content/early/2017/07/26/168765 Happy to finally implement it on a free server https://web.northeastern.edu/slavov/2014_HIquant/
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Our PLoS Computational Biology article:

-- How well do RNA levels predict protein levels?

A simple question confounded by a paradox
https://doi.org/10.1371/journal.pcbi.1005535
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