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Creative Bioarray
BioBank, Tissue Array, Cell Lines, FISH Probes
BioBank, Tissue Array, Cell Lines, FISH Probes

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Creative Bioarray's posts

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Creative Bioarray is a leading global product provider in the field of human cancer cell lines with low passage, validated and mycoplasma free cell lines. With years of experience and expertise, Creative Bioarray’s platform provides many different types of human cancer cell lines.

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Creative Bioarray offers over 1,000 stem cell products including adult stem cells, tumor stem cells, embryonic stem cells, iPS cells and other stem cells.

Adult Stem Cells are there to repair any damage that has been done to tissue and rebuild it back to its original state. We have many samples from different organs and systems of mice and rats.

Tumor Stem Cells samples are extremely valuable to those who need to compare them to normal stem cells of a certain origin and study how they give rise to cancerous cells.

Embryonic Stem Cells are available for both human and mouse embryos.

iPS Cells are cells that are derived from adult cells and are extremely useful in modeling diseases and drug development.

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What does it take to make meat from stem cells? 

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Creative Bioarray has compiled a list of scientific papers and patents relating to parts of our Core Products.

To better scan through the literature, there is a summary (if applicable) at the end of each reference written by Creative Bioarray, intending to display a general idea of the publication to provide a brief interpretation of the information within the publication.

For your convenience, we have grouped these patents and articles into the following categories:

SECTION 1: Cell lines & Medium
SECTION 3: Cytokines & Growth Factors
SECTION 5: Tissue Samples
SECTION 6: Tissue Microarrays

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The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target genotoxic endpoint, assessing not only clastogenic and aneugenic events but also some epigenetic effects, which is simple to score, accurate, applicable in different cell types. In addition, it is predictive for cancer, amenable for automation and allows good extrapolation for potential limits of exposure or thresholds and it is easily measured in experimental both in vitro and in vivo systems. Implementation of in vitro micronucleus (IVMN) assays in the battery of tests for hazard and risk assessment of potential mutagens/carcinogens is therefore fully justified. Moreover, the final draft of an OECD guideline became recently available for this test. In this review, the authors discuss the prerequisites for an acceptable MN assay, including the cell as unit of observation, importance of cell membranes, the requirement of a mitotic or meiotic division and the assessment of cell division in the presence of the test substance. Furthermore, the importance of adequate design of protocols is highlighted and new developments, in particular the in vitro 3D human skin models, are discussed. Finally, the authors address future research perspectives including the possibility of a combined primary 3D human skin and primary human whole blood culture system, and the need for adaptation of the IVMN assays to assess the genotoxic potential of new materials, in particular nanomaterials.

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Creative Bioarray offers a series of genotoxicity tests to identify chemicals that can cause genetic alterations in cells following the OECD test guidelines, including bacterial reverse mutation test OECD 471 (also known as Ames test), in vitro mammalian chromosomal aberration test OECD 473, in vitro mammalian cell micronucleus test OECD 487, in vitro gene mutation assays OECD 490, as well as other genotoxicity assays such as in vitro comet assay and genotoxicity screening.

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With a highly automated approach, Creative Bioarray provides highly cost-efficient S9 stability assay as one of our in vitro metabolism services and delivers consistent and high quality data.

Drug detoxification and drug metabolism are mostly carried out in the liver. Following oral administration, drugs are absorbed and transported to the liver to be metabolized primarily in this organ. About three-quarters of the drugs cleared via metabolism are metabolized by hepatic cytochrome P450 (CYP)-mediated metabolism1. Hepatic in vitro metabolism studies using hepatocytes, 9000g supernatant (S9), and microsomal fractions can give out valuable preliminary information on the in vitro metabolism of xenobiotics and shed light on the in vivo metabolism process of a candidate drug by the liver.

Compared to Hepatocytes which contain the full range of hepatic drug metabolizing enzymes and serve as the gold standard for metabolism studies, the S9 fraction is not only easier to handle but also sustains the major part of both phase I and phase II drug metabolizing enzymes, making it one of the perfect alternatives for in vitro drug metabolism studies.

Creative Bioarray is staffed with a group of well-experienced experts in drug metabolism and is able to provide customized S9 stability assays to assess the metabolic stability of your candidate drugs (microsomal stability assay is also available upon request).

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As the primary human corneal endothelial cells (HCEC) are limited and donor-derived differences between cultures exacerbate the issue of data reproducibility, the immortalized HCEC population was performed. HCEC-B4G12 is a clonal subpopulation started in 2005 from the parental cell line HCEC-12 established from normal cells of the posterior epithelium of the cornea of a 91-year-old Caucasian woman transformed with the early region of the SV40 genome including genes encoding large T-antigen and small t-antigen.
Scientists in Creative Bioarray consistently try our best to support your research!

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Epithelial cells are of diversity categories even within the same organism. They are also highly specialized cells that exist in carefully ordered multilayered structures. Creative Bioarray’s epithelial cell growth medium was fully formulated to support epithelial cells that derived from different organisms with optimal growth conditions. Based on the expertise of Creative Bioarray, our medium system ensures ideal cell health, viability, performance, physiology, morphology, consistency and data.

Key Features & Benefits

Human Epithelial Cell Growth Medium
a. Our human epithelial cells (HEC) growth medium is a medium developed for the cultivation of human derived epithelial cells.
b. By eliminating several growth factors and by adding certain hormones and epidermal growth factors, our medium can inhibit the growth of fibroblast cells that are close located to epithelial cells and stimulate epithelial proliferation.
c. Our HEC growth medium is specially designed for the culture of HEC with optimized growth supplement included.
d. Our HEC growth medium supports superior cell growth after thaw and throughout the guaranteed lifespan.

Mouse/Rat Epithelial Cell Growth Medium
a. This medium is optimized for primary mouse/rat epithelial cells in culture and readily available for researchers. It is designed for mouse/rat epithelial cell growth and proliferation in vitro.
b. This medium contains essential and non-essential amino acids, vitamins, organic and inorganic compounds, hormones, growth factors, trace minerals, which is designed for different kinds of mouse epithelial cells.
c. The supplement provides a defined and optimally balanced growth environment that maximally promotes the growth of mouse/rat epithelial cells in vitro.
Stability and Storage
Complete Medium should be stored in the dark at 4-8°C. Supplement kit should be stored at -20°C. Do not use past the expiration date.

When handling biohazardous materials such as human cells, safe laboratory procedures should be followed and protective clothing should be worn.

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New tool shines light on protein condensation in living cells

A tool that uses light to manipulate matter inside living cells has begun to explain how proteins assemble into different liquid and gel-like solid states, a key to understanding many critical cellular operations.
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