Written to the Roberts lab at Scripps to see if any compounds are left over from this paper, and which might be available for screening. They're very similar to some of the best antimalarial hits we've identified, and if they exist already we wouldn't need to spend time making them. This is an important aspect of the project - we need to find the relevant molecules as quickly as possible, no matter which fridge they happen to be in.
2 plus ones
Shared publicly•View activity
- That is a great idea, crowd-sourcing compounds!
As a matter of interest, how did you find this paper? Where there others? It might be useful to figure out a way to identify such papers/contact systematically.
1) identifying similar compounds in ChEMBL should point an original literature reference with contactable authors
2) identifying similar compounds that have been screened in "small" PubChem BioAssays should provide a screeners name who could be contacted.
This would be a natural extension of use of Open Data (discussed here https://plus.google.com/u/0/104186710895049917005/posts/2b8Qhp3npqD) only, instead of looking for identical compounds, look for similar compounds.Apr 19, 2012
- Finding similar compounds in ChEMBL can now easily be done in Bioclipse: http://bioclipse.blogspot.se/2012/04/chemical-decision-support-with.htmlApr 19, 2012
- This was a simple Scifinder search for compounds. We collected some other cases here
but need more. Essentially happy to contact anyone who might have relevant compounds - just need to know who they are!
For the pyrazole series we're thinking about doing (depending on the biology results for the current pyrrole series) we did a pubchem search which threw up some assays done by people we can get in touch with:
http://openwetware.org/wiki/OSDDMalaria:Arylpyrazole_SeriesApr 19, 2012
Add a comment...