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Krishan Maggon
Attended PHD
Lives in Geneva, Switzerland & New York, USA
138 followers|36,296 views
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Consultant Pharmaceutical Biotechnology R&D & Advisor
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  • Consultant Pharmaceutical Biotechnology R&D & Advisor, present
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Geneva, Switzerland & New York, USA
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Consultant and Advisor, New Drug Development and R&D
Introduction
                 

International pharma R&D adviser: new drug development, project management, business development, licensing, market introduction/support, contract and external research management and training.  Doctorate in Medical Biochemistry, over 100 publications.

Consultant and Advisor, New Drug Development and
Consultancy in New Drug Development, Licensing and Technology Transfer.

Krishan Maggon

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  • PHD
    Medical Biochemistry
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Krishan Maggon

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When you take a drug, it travels through your bloodstream, dissolving and dispersing, and eventually reaching its designated target area.
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by Matthew Prideaux, Sarah L. Dallas, Ning Zhao, Erica D. Johnsrud, Patricia A. Veno, Dayong Guo, Yuji Mishina, Stephen E. Harris, Lynda F. AbstractParathyroid Hormone (PTH) can exert both anabolic and catabolic effects on the skeleton, potentially through expression of the PTH type1 receptor (PTH1R), which is highly expressed in osteocytes. To determine the cellular and molecular mechanisms responsible, we examined the effects of PTH on osteobla...
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by Timucin Avsar, İlknur Melis Durası, Uğur Uygunoğlu, Melih Tütüncü, Nuri Onat Demirci, Sabahattin Saip, O. AbstractMultiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation and course. There is a remarkable phenotypic heterogeneity in MS, and the molecular mechanisms underlying it remain unknown. We aimed to invest...
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by Fanrui Meng, Bharat Joshi, Ivan Robert Nabi AbstractExpression of Caveolin-1 (Cav1), a key component of cell surface caveolae, is elevated in prostate cancer (PCa) and associated with PCa metastasis and a poor prognosis for PCa patients. Polymerase I and Transcript Release Factor (PTRF)/cavin-1 is a cytoplasmic protein required for Cav1-dependent formation of caveolae. Expression of PTRF reduces the motility of PC3 cells, a metastatic prostate...
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by Yang Li, Yong Liu, XiangPing Peng, Wei Liu, FeiYan Zhao, DanDan Feng, JianZhong Han, YanHong Huang, SiWei Luo, Lian Li, Shao Jie Yue, QingMei Cheng, XiaoTing Huang, ZiQiang Luo  AbstractBackgroundGlutamate is a major neurotransmitter in the central nervous system (CNS). Large amount of glutamate can overstimulate N-methyl-D-aspartate receptor (NMDAR), causing neuronal injury and death. Recently, NMDAR has been reported to be found in the lungs...
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Abstract Purpose: Patients with systemic lupus erythematosus (SLE) frequently develop lupus nephritis (LN), a complication frequently leading to end stage kidney disease. Immune complex deposition in the glomerulus is central to the development of LN. Using a targeted proteomic approach,we tested the hypothesis that autoantibodies targeting glomerular antigens contribute to the development of LN.Experimental Design: Human podocyte and glomerular ...
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Have him in circles
138 people
Darshan Pharmaindia's profile photo
Edward Vince's profile photo
Jill Gabani's profile photo
Beverly Saulters's profile photo
Sajid Khan's profile photo
Andreas Kemper's profile photo
steven lees's profile photo
dileep mishra's profile photo
Ram Makker's profile photo

Krishan Maggon

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by Mariell Pettersson, David Bliman, Jimmy Jacobsson, Jesper R. Nilsson, Jaeki Min, Luigi Iconaru, R. Kiplin Guy, Richard W. AbstractSmall molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulate PPIs is therefore of great significance to basic biology, where co...
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Highlights •PSM prolongs antigen early endosome localization and enhances cross-presentation•PSM activates type I interferon response in a TRIF/MAVS-dependent manner•PSM potentiates dendritic cell-based cancer immunotherapy SummaryMicro- and nanometer-size particles have become popular candidates for cancer vaccine adjuvants. However, the mechanism by which such particles enhance immune responses remains unclear. Here, we report a porous silicon ...
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by Marija MarÄ an, Bor Kos, Damijan MiklavÄ iÄ AbstractElectroporation-based treatments rely on increasing the permeability of the cell membrane by high voltage electric pulses applied to tissue via electrodes. To ensure that the whole tumor is covered with sufficiently high electric field, accurate numerical models are built based on individual patient anatomy. Extraction of patient's anatomy through segmentation of medical images inevitably pro...
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by Yang Li, Yong Liu, XiangPing Peng, Wei Liu, FeiYan Zhao, DanDan Feng, JianZhong Han, YanHong Huang, SiWei Luo, Lian Li, Shao Jie Yue, QingMei Cheng, XiaoTing Huang, ZiQiang Luo  AbstractBackgroundGlutamate is a major neurotransmitter in the central nervous system (CNS). Large amount of glutamate can overstimulate N-methyl-D-aspartate receptor (NMDAR), causing neuronal injury and death. Recently, NMDAR has been reported to be found in the lungs...
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by Wenlei Bao, Yanfeng Wang, Yuting Fu, Xiaoyang Jia, Jiaxin Li, Nyamtsengel Vangan, Lili Bao, Huifang Hao, Zhigang Wang AbstractBacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of mTORC1 in flagellin-induced inflammatory response is unknown. The purp...
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Lupus is the focus of intense research. Studies are looking at:The genes that play a role in lupus and in the immune systemWays to change the immune system in people with lupusLupus in different ethnic groupsThings in the environment that may cause lupusThe role of hormones in lupusBirth control pills and hormone therapy in women with lupusHeart disease in people with lupusThe causes of nervous system damage in people with lupusTreatments for lup...
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