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Stem Plus Cryopreservation
Transforming Waste Into Clinical GOLD
Transforming Waste Into Clinical GOLD


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🎉🎉🎉We are Happy to Announce that We are starting "Stem Plus Foundation"in Sangli🎉🎉🎉

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Differance Between Private Cord Blood banking & Public Cord Blood Banking.......!

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Listen Dr. Meghnad Joshi CMD Stem Plus Cryopreservation , sangli. On Stem Cell Banking

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Orthopaedic Stem Cell Therapy – Osteoarthritis, Joints, Neck, Back Pain

Orthopaedic Stem Cell Therapy
Stem cell therapy is now being extensively used to treat various orthopaedic conditions such as back pain, osteoarthritis, neck pain and joint pain. Intense exercise, ageing, injuries, and sports can cause a lot of wear and tear on the body. As human beings age, the production of mesenchymal stem cells is reduced hence slowing down the natural repair process. This makes the elastic tissue in joints and the back stiff, losing its elasticity, thus the increased risk of damage.
Orthopaedic stem cell therapy overview
Orthopaedic stem cell therapy is used in the repair of damaged tissues by using healing power of mesenchymal stem cells (MSCs) found in other body parts or from donor umbilical cord tissue. These MSCs have the ability to regenerate worn or damaged cartilage, repair damaged muscles & ligaments, control inflammation and rejuvenate aging cell populations.
Currently, stem cell therapy is being used in orthopaedic conditions such as:
• Osteoarthritis: This is a degenerative joint ailment
• Chronic tendonitis: This is the inflammation of the elastic tissue that links bone to muscle
• Degenerative vertebral discs
• Bone fractures
• Chronic back pain
• Neck and shoulders pain
About stem cell therapy
The majority of patients who have gone ahead with our stem cell therapy have reportedly find themselves in a better physical state, if not completely cured in many cases. During the treatment program the patient will an injection of MSCs into the affected joints and a supportive therapy program designed to stimulate the stem cells towards cartilage repair and inflammation modulation. In general the program for Orthopaedic treatment will last 3 to 5 days with supportive therapies given on a daily basis. All of our patients will also take home a personalized stem cell nutrition set tailored towards post injection stimulation of cartilage.
Stem cells types
The most common type of stem cells used in the treatment of joint pain, chronic back pain, muscular pain and other similar conditions are the mesenchymal stem cells. Such types of cells are normally taken from donor umbilical cord or in some cases the patients fat tissue or bone marrow.
Advantages and benefits of orthopaedic stem cells therapy
orthopaedic stem cell therapyThis approach to orthopaedic treatment is giving patients real therapeutic benefit and a restoration of their quality of life. Living in chronic pain with mobility restrictions can be greatly alleviated with regenerative medicine.

+ The procedure alleviates pain and offers a long lasting relief from chronic orthopaedic diseases.
+ The treatment uses Mesenchymal stem cells which hold many other health benefits to the patient.
+ Another interesting advantage of this remedy is the fact that relieves pain without the need for surgical procedures. It is especially useful in sports medicine; enables one resume to their sporting activities earlier than with surgery.
+ Finally, patients are less prone to the risks of surgeries like blood clots and infections.
Pre-procedure preparation
Before proceeding with stem cell therapy, it is wise to undergo an orthopaedic evaluation. It will assist in determining if you are a candidate for this type of stem cell treatment or not. More often than not, this involves obtaining X-rays or a magnetic resonance imaging (MRI) scan.
You should stop all non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and naproxen one week prior the procedure, thought the medical team at StemCells21 will give you complete safe guidelines to follow before, during and after the treatment.
You may be asked to stop taking any medication or supplements that thin the blood like aspirin and fish oil. In case you are taking drugs to prevent blood clots, then make sure you have detailed instructions from the medical team (when to stop and when to resume).
Post-procedure care
Following the orthopaedic stem cell therapy procedure, once the numbness sensation reduces you will experience mild pain as well as irritation for 24 to 48 hours. Normally, cold application for 10 to 20 minutes every two to three hours to the injection area, and a day to rest without exercise is all you need to ease the pain.
You should avoid anti-inflammatory medication as all cost for at least four weeks. The medical team may prescribe drugs to reduce pain. Inform them if you experience increased pain, fever, infection, and bleeding.
Cost of treatment and insurance policy
Despite the fact that stem cell therapy has been used for many years and studies have demonstrated its efficacy, its application in orthopaedic ailments is relatively new. As a result, this therapy is rarely included in your benefits by many insurance providers, so you may be liable for covering the treatment cost.
The cost of orthopaedic stem cell therapy may vary from patient to patient, depending on specific needs, conditions and other factors.
Important factors in orthopaedic stem cell treatment
Here are things to keep in mind and ensure you get quality treatment whilst maximizing your chances of a successful outcome:
1. Specialty The procedure is as good as the medical practitioner executing it. It can be the best therapy in the planet, but if the physician doesn´t understand the placement of needles and cells, it’s a waste of money and time. StemCells21 expert medical team provides years of experience and state-of the-art medical facilities to guarantee the best outcome possible.
2. Most people are treated with over-the-counter anti-inflammatory medication, physical therapy, hyaluronic injections, and weight loss when obesity plays an important role in the orthopaedic condition.
Stem cell treatment is a revolutionary and effective approach based on sound biological principles. Many studies have shown remarkable results and as more success stories of orthopaedic stem cell therapy continue to emerge, this type of treatment is expected to grow in popularity.

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Allogeneic cell therapy using umbilical cord
MSCs on collagen scaffolds for patients
with recurrent uterine adhesion: a phase I
clinical trial
Background: Intrauterine adhesions (IUA) are the most common cause of uterine infertility and are caused by
endometrium fibrotic regeneration following severe damage to the endometrium. Although current stem cell
treatment options using different types of autologous stem cells have exhibited some beneficial outcomes in IUA
patients, the reported drawbacks include variable therapeutic efficacies, invasiveness and treatment unavailability.
Therefore, the development of new therapeutic stem cell treatments is critical to improving clinical outcomes.
Methods: Twenty-six patients who suffered from infertility caused by recurrent IUA were enrolled in this prospective,
non-controlled, phase I clinical trial with a 30-month follow-up. During the procedure, 1 × 107 umbilical cord-derived
mesenchymal stromal cells (UC-MSCs), loaded onto a collagen scaffold, were transplanted into the uterine cavity
following an adhesion separation procedure. Medical history, physical examination, endometrial thickness, intrauterine
adhesion score and the biological molecules related to endometrial proliferation and differentiation were assessed
both before and 3 months after cell therapy.
Results: No treatment-related serious adverse events were found. Three months after the operation, the average
maximum endometrial thickness in patients increased, and the intrauterine adhesion score decreased compared to
those before the treatment. A histological study showed the upregulation of ERα (estrogen receptor α), vimentin, Ki67
and vWF (von Willebrand factor) expression levels and the downregulation of ΔNP63 expression level, which indicates
an improvement in endometrial proliferation, differentiation and neovascularization following treatment. DNA short
tandem repeat (STR) analysis showed that the regenerated endometrium contained patient DNA only. By the end of
the 30-month follow-up period, ten of the 26 patients had become pregnant, and eight of them had delivered live
babies with no obvious birth defects and without placental complications, one patient in the third trimester of
pregnancy, and one had a spontaneous abortion at 7 weeks.

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Are stem cells and regenerative medicine living up to their promises?
Stem cell therapy's concept is deceptively simple: take cells from a donor and put them into a patient to treat a disease or injury. However, the reality falls far short of the dream.
Regenerative medicine makes use of cells, biomaterials, and molecules to fix structures in the body that do not function properly due to disease or injury.

What sets regenerative medicine apart from many traditional drugs is that the latter mostly treat symptoms, whereas the former aims to treat the root cause of a patient's condition by replacing lost cells or organs, or by fixing a faulty gene.

The allure of regenerative medicine promises to redefine medical treatment, putting stem cells and biocompatible materials center stage in this revolution. Many breakthroughs have been reported and hailed in scientific journals and the media over the years.

However, the number of regenerative medicine treatments in medical use today is disappointingly low, and a panel of commissioners criticizes this lack of progress in a report published last week in The Lancet.

In fact, according to Prof. Giulio Cossu - from the Division of Cell and Matrix Biology & Regenerative Medicine at the University of Manchester in the United Kingdom - and his fellow commissioners, only a handful of breakthroughs have made it to patients, and private clinics are cashing in on patients' desperate search for treatments by offering unproven therapies.

Why have so many promises of new therapies fallen short? And what will it take for society to benefit from the immense potential that regenerative medicine holds?

What is regenerative medicine?
The commissioners say in their report that regenerative medicine "aims to replace or repair human cells, or regenerate tissue or organs to restore normal function." The emphasis on "normal function" sets this approach to medical treatments apart from many commonly used drugs, which tend to treat symptoms but do not address the underlying causes.
"Cell therapies and regenerative medicine, with their potential to improve the health of patients, represent a structural shift in healthcare by focusing on the underlying causes of disease by repairing, replacing, or regenerating damaged cells in the body," the authors explain.
For example, an individual with type 1 diabetes cannot produce insulin. Instead, daily insulin injections are required to keep blood sugar levels in check.
Regenerative medicine seeks to solve this by regenerating the islets of Langerhans, which allow the individual to make insulin. This would mean no more insulin injections and a return to normal sugar metabolism.
While the treatment of type 1 diabetes in this way is not yet a reality, there are some areas of regenerative medicine that are well established in medical practice.

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What Birth Control Is OK When You’re Breastfeeding?
Your new baby is here, and you know that you’re not ready to get pregnant again. So what type of birth control is best while you breastfeed?

You have a little time to decide. Most doctors recommend that new moms not have sex until after the 6-week checkup. So, you may not even need birth control before your baby is 6 weeks old.

When the time comes, you'll have a lot of options for contraception.

Birth Control Pills

You may have heard that some could curb your milk supply, which would make it harder to feed your baby. It’s true that some hormones may have that effect. But not all do.

There are two types of birth control pills:

Combination ones include the hormones estrogen and progestin
Others only have progestin. Some people call these the “mini-pill.”
Estrogen may mean you make less milk. So when you tell your doctor that you’re breastfeeding, she'll probably prescribe the mini-pill. It shouldn’t affect your milk supply at all.

If your doctor thinks combination pills are better for you than the mini-pill, she’ll likely wait 5 or 6 weeks, before she prescribes one for you.

There's another reason why you may need to wait before you take combination pills -- they make blood clots more likely in the first few weeks after you have a baby. So, it’s wise for all women -- even those who bottle-feed -- to hold off on them during the first month after childbirth.


If you want long-term birth-control that isn’t permanent, you may want to consider an IUD (intrauterine device). Your doctor can insert it into your uterus after you give birth or 6 weeks later during an office visit. You don’t have to remember to take a pill daily or do anything special before sex for an IUD to work.

Two types are available: one that’s copper and another that contains the hormone progestin. Either one is fine for nursing moms. The copper IUD has no hormones to affect your milk supply. The other has low levels of progestin, which won’t cause problems with your supply.

You may want to wait until your 6-week checkup to get your IUD inserted. If you get it right after your baby is born, there’s a chance that your body will push it out.

Umbilical cord tissue cryopreservation: a short review

In this review we present current evidence on the possibility of umbilical cord tissue cryopreservation for subsequent clinical use. Protocols for obtaining umbilical cord-derived vessels, Wharton’s jelly-based grafts, multipotent stromal cells, and other biomedical products from cryopreserved umbilical cords are highlighted, and their prospective clinical applications are discussed. Examination of recent literature indicates we should expect high demand for cryopreservation of umbilical cord tissues in the near future.
In 1974, umbilical cord blood (UCB) was reported to be a source of hematopoietic stem and progenitor cells [1], and in 1988, the first transplantation of cryopreserved UCB to an infant with Fanconi anemia, an inherited bone marrow disease, was performed in France [2]. Over the next 30 years, numerous studies were published demonstrating the regenerative potential of particular UCB-derived cell populations, and a global network of public and private biobanks of UCB was established [3, 4].

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It is Great Feeling to inform You all That our CMD Dr. Meghnad Joshi ji {Stem Plus Cryopreservation} is Appointed on "Co-Option of the Board Of Studies in Zoology" Shivaji University Kolhapur Provision Under Section 62-63 of Maharashtra Public University at 2016

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Stem Cells for Heart Failure Treatment
Most treatment for heart failure can only slow it down or ease your symptoms. Soon, it may be possible to fix what causes it. Doctors are testing whether stem cells can repair or replace damaged heart cells.
Where Do Stem Cells Come From?
Stem cells can grow into many different kinds of cells. You have them in organs and tissues all over your body. They divide to replace worn-out or damaged cells, and to become new stem cells.
In the lab, scientists have turned stem cells into ones that make up blood vessel walls and linings, and into actual beating heart cells. Now they’re trying to translate that into a treatment.
Scientists have zeroed in on a few specific kinds of cells that may be helpful

How Well Does It Work?
There’s no way to fix heart damage that leads to heart failure. Stem cell therapy could change that. Still, it’s too early to call any treatment a success. The studies done so far have been too small. They've also used very different methods.

But it does look like stem cells could help repair heart tissue. In most studies, people who got them were less likely to die or go to the hospital during the study. Their hearts worked better and their quality of life was better than for people who didn’t get them.
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