There's a new CMS that was released as a public beta yesterday, called Craft. http://buildwithcraft.com/
It's targeted for those of you used to mid-level, locally installable tools like Drupal and ExpressionEngine, especially if you like to start with a blank slate of content and HTML.
It uses Twig as the templating language and the Yii PHP framework as the base code, and it's written by one of the top ExpressionEngine add-on developers. This is getting interesting!