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Regenerative Sciences Institute
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What would you do to stay healthy into old age, to have the time to live life full measure?
What would you do to stay healthy into old age, to have the time to live life full measure?

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Nicotinamide riboside extends mouse lifespan, boosts stem cell function, and anti-diabetes 2 http://www.nature.com/articles/srep26933

http://science.sciencemag.org/content/early/2016/04/27/science.aaf2693

NR boosts NAD+ But the effect of NR on lifespan is modest. How do epigenetic signatures change after NAD depletion? Is it like aging or not?

1st steps to engineer regeneration. Regenerative enhancer elements from zebrafish work correctly in mice. 
http://www.nature.com/nature/journal/v532/n7598/full/nature17644.html

Overcoming cell #senescence helps, but is not a panacea to block #aging. There is only a 25% increase in the lifespan of mice after killing senescent cells.

If you kill p16 expressing "senescent" cells, then mice live 25% longer. http://dx.doi.org/10.1038/nature16932 … and http://www.nature.com/news/destroying-worn-out-cells-makes-mice-live-longer-1.19287#antiaging effects

Is the increased longevity effect due to true anti-aging or to just killing cancer cells that express p16ink4a, but still proliferate? There is some improvement to kidney and heart function, but enough to increase lifespan? Or is it just the anti-cancer effect?

CAF-1 maintains cell identify by maintaining chromatin. Reducing CAF-1 makes reprogramming and transdifferentiation more efficient.

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"Can we actually s l o w aging with science?@RealRonHoward investigates in this week's episode of #Breakthrough."

https://amp.twimg.com/v/4763eda1-e964-4a4e-95fd-905d48b9cf3c

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J147, a small neurotrophic molecule has potent #antiaging and anti-Alzheimer's  activity in mice. http://www.eurekalert.org/pub_releases/2015-11/si-edt111215.php
Next comes the search for the mechanism.

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