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McMaster Immunology Research Centre
Cancer; Infectious Disease & Gene-based Vaccines; Respiratory Diseases & Allergies: Rheumatoid Arthritis
Cancer; Infectious Disease & Gene-based Vaccines; Respiratory Diseases & Allergies: Rheumatoid Arthritis


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Idiopathic Pulmonary Fibrosis (IPF): An Overview. Students in the "HTHSCI-4DM3 Demystifying Medicine" course interviewed Dr. Gerry Cox, a clinician-scientist who specializes in IPF, to disseminate information that patients need. #lungs 

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Today's McMaster Demystifying Medicine Seminar Series looks at cardio-renal syndrome, and features clinical, patient and research presentations!

4pm in MUMC 1A6.

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It's Fridaaaay! To celebrate, here's a very cool video of how Leishmania reproduces in a mosquito.

3 minutes 12 seconds of your life well spent.

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Almost 100% of people infected with the bacteria, Yersinia pestis, die from the bubonic plague.

Researchers have now characterised the early movements of these infecting bacteria, who first inject effector proteins into alveolar macrophages to shut them down and create a protective environment.

The body, sensing a pathogenic invader, responds by pouring immune cells - the neutrophils - into the lung to try and suppress bacterial growth.

Unfortunately, the neutrophils usually fail to control the bacteria, and while they're trying, cause serious inflammation, cytokine storms and death.

Suppressing neutrophils can actually help an infected host, and may represent a good treatment should the Black Death resurrect itself.

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Memory T cell exhaustion is often imagined as a gradual process, where prolonged viral antigen stimulation renders cells too tired to continue fighting.

Such exhausted cells stop producing cytokines
(IL-2 gets canned first, followed by TNFa and IFNg), and upregulate multiple inhibitory receptors.

New research now suggests that markers of T cell "exhaustion" first appear just 24h following viral infection, and may in fact simply be a normal part of the immune response, where losing IFNg but retaining GrzB protects the body from immune pathology while maintaining anti-viral functionality.

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MIRC researchers Dr. Zhou Xing and Dr. Fiona Smaill develop a new TB vaccine that in pilot studies appears to be very effective in boosting immune responses.

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Today, our McMaster Demystifying Medicine Seminar Series looks at why it's important for scientists to engage and partner with the community.

MDCL 3020 from 4pm.

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For all Hammer/GTA Scientists:

"Ambient plagues", a bioart exhibition by artist Elaine Whittaker, is running at the Red Head Gallery in Toronto until 28th September

"Through sculpture, photography, microscopy, and live bacteria, the artworks blur the boundaries between what is real and what is manufactured, what is animate and what is inanimate".

H/T +Glendon Mellow 

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Join MIRC researchers, including +Dawn Bowdish and +Jennifer Stearns, to "stand up for science" on Monday 16th September at Hamilton City Hall, 9am.

The rally will highlight the continued decline of evidence-based fundamental research in Canada, including the Harper government-driven push for corporate science.
Let's do this! The Hamilton contingent looks thin. Sign up by following the link "coast to coast" in the 5th paragraph

Very cool new research from the IIDR shows how weather patterns impact influenza virus spreading across Canada.

Spoiler: Flu spreads from West to East, and depends on low temperatures and humidities.
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