Best way to drive 30 000 Leds ?

I work on an artistic installation with 30 000 leds (may be 42 000 futures)
This is not for a video screen so I do not need a high refresh rate. (This point remains to be determined)
As much for piloting a limited number of leds I understand well how to go about, as much for a project of this magnitude I have some doubts and therefore prefer to call the experts.
Which controller do you think should be used?
According to my research, the best solution would be several teensy connected. Am I right?
How to determine the number of teensy?
What are the alternatives?

Thank you´╗┐
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