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John Gowers
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John Gowers

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I don't know how it's taken me so long to come across this pattern.  The Life enthusiasts among you will find this rather exciting (provided you didn't see it several years ago when it was discovered).
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John Gowers

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John Gowers

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I think 'racism' is the wrong term, since British isn't really a race per se; however, discriminating against people on the grounds of nationality is a prejudice just as bad as discriminating against them based on their skin colour - it just hasn't got the stigma attached to it that racism has.
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I agree with that. I also find it deeply depressing that every time Farage gave some statistics, the interviewer said, "You're getting bogged down in figures here: remember what happened to Nick Clegg when he did that." (I'm not applauding Farage's use of statistics, but I'm condemning the interviewer's attitude to statistics in general.)
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Can somebody help me with a point in this paper?  On page 5326, near the top of the right hand column, the authors say, "Analyses to date, including our work, imply that duplex stabilisation by 5mC is predominantly due to entropic rather than enthalpic effects."  However, Figure 3 just above shows marked differences in the enthalpy of the duplex containing 5mC and that containing unmethylated cytidine, that are just as significant as the differences in entropy shown alongside.  How, then, are they led to the conclusion that the difference is due to entropic effects and not to enthalpic effects?  

Note: PMID 1945840 says that "the effect of substituting, in the stem of hairpin CGCGCGTTTCGCGCG, the cytosines with 5-methylcytosines enhances the Tm from 74° to 82 °C, while the DeltaH of both hairpins is - 213 kJ/mol", which appears to corroborate the authors' statement.  

#spnetworkwas     PMID:21451870 
#spnetworkabuse  
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To answer my own question: if we go by the data in this article, the operative word is 'predominantly'.  Supplementary table S2 gives the linear regression parameters that were determined in order to give the graphs in Figure 3 (which are misleading anyway, since they don't start from 0).  The 95% confidence intervals for the slope in the C and 5mC cases are disjoint; since the slope is given by (R/Delta H), we should reject the hypothesis that Delta H is the same for C and for 5mC at the 5% level, which means that the duplex stabilization is not entirely due to entropic effects. 

This still stands in opposition to the results in PMID 1945840, so I'd be interested if anyone has anything else to say about this problem. 
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