TREATMENT DEPERSONALIZATION
The SSRIs, in decreasing toxicity in overdose, can be listed as follows:[98]
Citalopram (due to the potential for QT interval prolongation)
Fluvoxamine
Escitalopram
Paroxetine
Sertraline
Fluoxetine
 
List of agents[
Drugs in this class include (trade names in parentheses):
citalopram (Celexa, Cipramil, Cipram, Dalsan, Recital, Emocal, Sepram, Seropram, Citox, Cital)
dapoxetine (Priligy)
escitalopram (Lexapro, Cipralex, Seroplex, Esertia)
fluoxetine (Depex, Prozac, Fontex, Seromex, Seronil, Sarafem, Ladose, Motivest, Flutop, Fluctin (EUR), Fluox (NZ), Depress (UZB), Lovan (AUS), Prodep (IND))
fluvoxamine (Luvox, Fevarin, Faverin, Dumyrox, Favoxil, Movox, Floxyfral)
indalpine (Upstene) (discontinued)
paroxetine (Paxil, Seroxat, Sereupin, Aropax, Deroxat, Divarius, Rexetin, Xetanor, Paroxat, Loxamine, Deparoc)
sertraline (Zoloft, Lustral, Serlain, Asentra, Tresleen)
zimelidine (Zelmid, Normud) (discontinued)
 
Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitors[1] (SSRIs) are a class of compounds typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having only weak affinity for the norepinephrine and dopamine transporter.
 
Benzodiazepines are generally viewed as safe and effective for short-term use,
Common type
2-keto compounds:
chlordiazepoxide, clorazepate, diazepam, flurazepam, halazepam, prazepam, and others.[118][119]
3-hydroxy compounds:
lorazepam, lormetazepam, oxazepam, temazepam[118][119]
7-nitro compounds:
clonazepam, flunitrazepam, nimetazepam, nitrazepam[118][119]
Triazolo compounds:
adinazolam, alprazolam, estazolam, triazolam[118][119]
Imidazo compounds
climazolam, loprazolam, midazolam
 
Benzodiazepine
Half-life (range, h)
Speed of Onset
Alprazolam
12–15
Intermediate
Chlordiazepoxide
10–30
Intermediate
Clonazepam
10–50
Slow
Diazepam
20–80
Fast
Lorazepam
10–20
Intermediate
Oxazepam
5–10
Slow
Prazepam
50–200
Slow
 
hort-acting compounds have a median half-life of 1–12 hours. They have few residual effects if taken before bedtime, rebound insomnia may occur upon discontinuation, and they might cause daytime withdrawal symptoms such as next day rebound anxiety with prolonged usage. Examples are brotizolam, midazolam, and triazolam.
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