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DiEthylStilbestrol DES
3,957 followers -
About cancer, EDCs, pharma and pregnancy prescription drugs. Health updates include DES transgenerational effects.
About cancer, EDCs, pharma and pregnancy prescription drugs. Health updates include DES transgenerational effects.

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1977 - Seventy-one offspring of mothers administered combinations of synthetic progestins and estrogen for the maintenance of at-risk pregnancy were evaluated for their performance on IQ and personality tests. Siblings born of untreated pregnancies acted as controls. Hormone-exposed subjects were partitioned into three treatment subgroups dependent on the ratio of progestin to estrogen administered to their mothers during pregnancy.

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Participants - a total of 1,085 DES-exposed and 1,047 unexposed men - were identified through record review, clinical trial participation, or an obstetrics clinic. #fertility #sterility #MensHealth

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This 2001 study, which is larger and includes a considerably longer follow-up period than any previous study, indicates that women exposed to #diethylstilbestrol in utero have an increased risk of infertility, both primary and secondary, and that the increase is primarily due to tubal and uterine factors.

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Female offspring were evaluated for onset of puberty, ovarian function, and lordosis and mounting behavior in adulthood.

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Although the basic tenet of medicine is “First, do no harm,” history is filled with good intentions that were at best unhelpful and at worst harmful... #diethylstilbestrol

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In France around 80,000 women have had in utero DES exposure. The cases of four young women who consulted our Reproduction Center for reproductive disorders illustrate the usual difficulties faced by these patients.

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1994 - Studies of women exposed to high levels of estrogens prenatally could provide information regarding effects of early exposure to masculinizing hormones on sexual differentiation of brain and behavior independent of influences on the external genitalia.

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2015 results suggest a significant increase of breast cancer in prenatally DES exposed women when compared with unexposed women and with the general population. For other cancers, except clear cell carcinoma of the cervix or vagina, there was a global non-significant increase.

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