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Ruggero Cortini
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We recently developed a technology to study the relationship between HIV and the genome of the host. With B-HIVE (Barcoded HIV Ensembles), we hope to understand why and how HIV sometimes becomes latent and hides in the genome of infected cells.

The gist of B-HIVE is to label viruses with a DNA barcode that allows us to trace them in a heterogeneous population. With this barcode we can tell which viruses are active, which are latent, and which are reactivated by different drugs.

To our surprise, we discovered that drugs have very different activities, depending on where HIV hides. We do not fully understand why that is the case, but this has important implications for the development of antiretroviral therapies.

Our work has just been published at Nature Structural and Molecular Biology.
http://www.nature.com/nsmb/journal/vaop/ncurrent/full/nsmb.3328.html

#science
#HIV
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