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Stem Cell Info
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An informational resource dedicated to stem cells, research news, and clinical trials
An informational resource dedicated to stem cells, research news, and clinical trials

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►ALS. After successful preclinical studies, Israeli biotech, Kadimastem, is recruiting for a small-scale clinical study testing their stem cell therapy, AstroRx, in patients with ALS. The recent research based on animal studies suggested an additional mechanism-of-action by which stem cell therapy could delay disease progression.
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►Heart Failure. A heart failure-patient shares her experience after gaining a significant improvement from stem cell therapy – a treatment she decided on after all conventional medical options had been exhausted. A UK-based clinical trial is currently underway to assess the efficacy of stem cells in a large pool of patients. The procedure has the potential to significantly improve patient outcomes including fewer side-effects.
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►Multiple Sclerosis. Interim data from a long-term MS study that compared stem cell therapy with conventional drug treatment suggest promising results so far. One patient in the clinical trial shares her experience in an interview – a procedure which in her case was able to stop the disease.
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►Lung Disease. Research based on an animal model suggests mesenchymal stem cells have both the ability to reduce tissue inflammation and restore lung function. The findings support potential future new treatment options for patients suffering from conditions such as COPD and cystic fibrosis.
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►Multiple Sclerosis. Results from a long-term study suggest that a combination of chemotherapy followed by a stem cell transplantation yields a better outcome for patients suffering from MS than would otherwise be the case with traditional medication. Five years after the original single-therapy intervention, 69% of the participants had not experienced any relapse and importantly had not taken MS-medication during the entire period. Read the full details via the embedded link, below.

Research Publication (DOI):

dx.doi.org/10.1212/WNL.0000000000003660
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►Crohn's Disease. Results from a 52-week post treatment follow-up indicate that adipose-derived stem cells provided a superior outcome for patients with complications from Crohn's disease. The disease itself is believed to affect up to 1.6 million people in Europe alone. Stem cells are known to be immunomodulatory and may therefore provide certain patient populations with new therapeutic options.
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►Anti-Ageing. Stem cells are known to have the potential for inducing an anti-ageing effect. But, the source of stem cells for rejuvenation purposes can vary. However, new research from the University of Pennsylvania shows that stem cells derived from fat tissue make up an attractive harvesting source as these cells are particularly stable throughout a person's life. Patients can therefore use their own stem cells for anti-ageing therapy purposes at any stage of life. Read more via the link below.
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►Brain Cancer. Scientists have successfully used reprogrammed stem cells in order to attack cancerous tumours in mice. The recent progress relies on a technique which converts stem cells from one type to another at a greater speed - thereby making the procedure a viable option for human treatment. Results from animal-based experiments showed a 20-fold reduction (or more) in tumour size, post treatment. By using tumour-homing stem cells that act locally, side-effects from conventional therapy are also reduced. Clinical trials in humans are still pending, however.
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►Juvenile Arthritis. In an unusual mix of politics and healthcare, the story of Sarah Hughes resurfaced. A long-time sufferer of juvenile arthritis, she finally found relief in 2014 after receiving several infusions of stem cells. The procedure - which involved her own stem cells - reduced her daily medication intake from 23 different variants down to eight - and at lower doses. The rationale for employing stem cells in the treatment of autoimmune disorders has previously been accounted for in the scientific literature:

https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-9-181
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