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STEM CELLS
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From the Bench to Patient Care
From the Bench to Patient Care

37 followers
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STEM CELLS's posts

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Mesenchymal Stem Cells: Time to Change the Name! - Caplan

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Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy
Mesenchymal stem/stromal cells (MSCs) are being exploited as an experimental therapy for a variety of human diseases. Current dogma indicates that MSCs ameliorate disease via secretion of paracrine acting factors that limit inflammation, reprogram immune cells, and activate endogenous repair pathways. Recent studies indicate that MSCs also produce extra-cellular vesicles of varying sizes including exosomes that carry as cargo mRNAs, microRNAs, and proteins, and that horizontal transfer of this cargo induces nonautonomous changes that are therapeutic. This manuscript reviews evidence that MSC-derived microvesicles/exosomes function as paracrine mediators in tissue repair and recapitulate to a large extent the therapeutic effects of parental MSCs. It also discusses their role in reprogramming endogenous MSCs to generate a self-reinforcing malignant niche.

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Dr. Cooke discusses the role of RIG1-like receptor pathway in nuclear reprogramming. http://ow.ly/iwYc30ap479

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Stem Cell Treatment Has Potential to Help Parkinson’s Disease Unexpected Brain Area

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Human induced pluripotent stem cells provide a unique opportunity to dissect the roles of genetic variants for pathogenesis. This review overviews recent developments how induced pluripotent stem cell research will further contribute to human health in the coming era of precision medicine.

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Phase I/IIa studies show efficacy and safety of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in patients with moderate-to-severe atopic dermatitis (AD) as a promising alternative therapy.

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The Stem-Cell Revolution Is Coming — Slowly - A conversation with Shinya Yamanaka
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