Profile

Cover photo
Bharat IndiaQBank
Worked at AIIMS
Attended St Anns
Lives in India
107 followers|16,631 views
AboutPostsPhotosVideos

Stream

Bharat IndiaQBank

Shared publicly  - 
 
Cholelithiasis
Instructional Tutorial Video
CanadaQBank.com
QBanks for the MCCEE, MCCQE, USMLE

http://youtu.be/FvTh4pWjtr4
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: lipoproteins

Q 34. All of the following statements are true regarding lipoproteins except:

A. VLDL transports endogenous lipids
B. LDL transports lipids to the tissues.
C. Increased blood cholesterol is associated with increased LDL receptors
D. Increased HDL is associated with decreased risk of coronary disease

Ans. C

Low-density lipoprotein (LDL) is the most abundant and the most atherogenic class of cholesterol-carrying lipoproteins in human plasma. The level of plasma LDL is regulated by the LDL receptor, a cell surface glycoprotein that removes LDL from plasma by receptor-mediated endocytosis.

Defects in the gene encoding the LDL receptor, which occur in patients with familial hypercholesterolemia, elevate the plasma LDL level and produce premature coronary atherosclerosis. The physiologically important LDL receptors are located primarily in the liver, where their number is regulated by the cholesterol content of the hepatocyte. When the cholesterol content of hepatocytes is raised by ingestion of diets high in saturated fat and cholesterol, LDL receptors fall and plasma LDL levels rise.

Conversely, maneuvers that lower the cholesterol content of hepatocytes, such as ingestion of drugs that inhibit cholesterol synthesis (mevinolin or compactin) or prevent the reutilization of bile acids (cholestyramine or colestipol), stimulate LDL receptor production and lower plasma LDL levels.

http://circ.ahajournals.org/content/76/3/504.full.pdf

For more questions check http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: pyrimidines

Q 33. False regarding gout is:

A. Due to increased metabolism of pyrimidines
B. Due to increased metabolism of purines
C. Uric acid levels may not be elevated
D. Has a predilection for the great toe

Ans. A

Gout is a medical condition usually characterized by recurrent attacks of acute inflammatory arthritis—a red, tender, hot, swollen joint. The metatarsal-phalangeal joint at the base of the big toe is the most commonly affected (approximately 50% of cases). However, it may also present as tophi, kidney stones, or urate nephropathy. It is caused by elevated levels of uric acid in the blood. The uric acid crystallizes, and the crystals deposit in joints, tendons, and surrounding tissues.

High levels of uric acid in the blood (hyperuricemia) is the underlying cause of gout. This can occur for a number of reasons, including diet, genetic predisposition, or underexcretion of urate, the salts of uric acid.

Dietary causes account for about 12% of gout,and include a strong association with the consumption of alcohol, fructose-sweetened drinks, meat, and seafood. Other triggers include physical trauma and surgery.Recent studies have found that other dietary factors once believed associated are, in fact, not, including the intake of purine-rich vegetables (e.g., beans, peas, lentils, and spinach) and total protein.

Schlesinger N (March 2010). "Diagnosing and treating gout: a review to aid primary care physicians". Postgrad Med 122 (2): 157–61.

For more questions check http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: purine bases

Q 32. Which of the following RNA has abnormal purine bases:

A. tRNA
B. mRNA
C. rRNA
D. 16SRNA

Ans. A

Important points to remember about t-RNA are:

- tRNAs have an inverted L structure
- has abnormal purine bases:

- tRNAs have an anticodon loop that pairs with a mRNA codon
- - there is a tRNA for each amino acid
- - amino acids are attached to tRNAs via ester linkage to the 3'-OH by specific aaRS to form charged tRNAs
- - charged tRNAs pair with the mRNA codons in the P and A sites of the 70S initiation complex
- - peptide chain elongation proceeds when the attached amino acid of the tRNA in the P site forms a peptide bond with the amino acid of the tRNA in the A site
- - The crystal structure of tRNA elucidates other important points:
- - tRNAs all have an inverted L structure
- - tRNAs have conserved structural features: 5'P, D arm, anticodon arm, variable arm, TyC arm, 3' amino acid acceptor stem
- - tRNAs contain unusual bases
- - tRNAs are made up of a single chain of RNA yet have considerable tertiary structure arising from base pairing within the chain
- - there are several non-Watson-Crick base pairs that take part in cross-linking
- - tRNAs are narrow so as to be able to sit next to one another on adjacent mRNA codons in the P and A sites
- - the anticodon arm and amino acid acceptor stems are solvent accessible regions of the molecule

http://www.wiley.com/college/boyer/0470003790/structure/tRNA/trna_intro.htm

For more questions check http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: Triple bonds

Q 31. Triple bonds are found between which base pairs:

A. A-T
B. C-G
C. A-G
D. C-T

Ans. B

Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA. Guanine has two tautomeric forms, the major keto form  and rare enol form. It binds to cytosine through three hydrogen bonds. 

Guanine can be hydrolyzed with strong acid to glycine, ammonia, carbon dioxide, and carbon monoxide. Guanine is first deaminated to xanthine. Guanine oxidizes more readily than adenine, the other purine-derivative base in DNA. Its high melting point of 350 °C reflects the intermolecular hydrogen bonding between the oxo and amino groups in the molecules in the crystal. Because of this intermolecular bonding, guanine is relatively insoluble in water, but it is soluble in dilute acids and bases.

 Hitchings, George H.; Elvira A. Falco (1944-10-15). "The Identification of Guanine in Extracts of Girella Nigricans" (PDF). Proc. Natl. Acad. Sci. USA 30 (10): 294–7.

For more details please check : http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: Cellular oxidation

Q 30. Cellular oxidation is inhibited by:
A. Cyanide
B. Carbon dioxide
C. Chocolate
D. Carbonated beverages
Ans. A

A cyanide is any chemical compound that contains monovalent combining group CN. This group, known as the cyano group, consists of a carbon atom triple-bonded to a nitrogen atom.

In inorganic cyanides, such as sodium cyanide, NaCN, this group is present as the negatively-charged polyatomic cyanide ion (CN-); these compounds, which are regarded as salts of hydrocyanic acid, are highly toxic. The cyanide ion is isoelectronic with carbon monoxide and with molecular nitrogen. Most cyanides are highly toxic.

Organic cyanides are usually called nitriles; in these, the CN group is linked by a covalent bond to a carbon-containing group, such as methyl (CH3) in methyl cyanide (acetonitrile).

Cyanide inhibits aerobic metabolism by binding to the binuclear heme center of cytochrome c oxidase (CcOX). Amyl nitrite and sodium nitrite (NaNO(2)) antagonize cyanide toxicity in part by oxidizing hemoglobin to methemoglobin (mHb), which then scavenges cyanide. mHb generation is thought to be a primary mechanism by which the NO(2)(-) ion antagonizes cyanide.

http://www.ncbi.nlm.nih.gov/pubmed/20335280
See more at : http://bit.ly/1jX6rku
1
Add a comment...
Have her in circles
107 people
Rakesh Jha's profile photo
Nuéng Jirawat (Jee)'s profile photo
Kaplan Medical Licensing USMLE & COMLEX-USA Prep's profile photo
Soumitro Deb's profile photo
Jackson Walt's profile photo
arjun mehndiratta's profile photo
Shashir Meshram's profile photo
Tushar Motghare's profile photo
Ema Rickijevic's profile photo

Bharat IndiaQBank

Shared publicly  - 
 
CanadaQBank.com
Instructional Tutorial Video
Subarachnoid Hemorrhage (SAH)
QBanks for the MCCEE, MCCQE, USMLE

http://youtu.be/9MkdDQdT02c
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: lipoproteins

Q 34. All of the following statements are true regarding lipoproteins except:

A. VLDL transports endogenous lipids
B. LDL transports lipids to the tissues.
C. Increased blood cholesterol is associated with increased LDL receptors
D. Increased HDL is associated with decreased risk of coronary disease

For answers please check : http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: pyrimidines

Q 33. False regarding gout is:

A. Due to increased metabolism of pyrimidines
B. Due to increased metabolism of purines
C. Uric acid levels may not be elevated
D. Has a predilection for the great toe

For answers please check : http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: purine bases

Q 32. Which of the following RNA has abnormal purine bases:

A. tRNA
B. mRNA
C. rRNA
D. 16SRNA

For answers please check : http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: Triple bonds

Q 31. Triple bonds are found between which base pairs:

A. A-T
B. C-G
C. A-G
D. C-T

For answers please check : http://bit.ly/1jX6rku
1
Add a comment...

Bharat IndiaQBank

Shared publicly  - 
 
Exam: 2004 FMGE exam
Subject: Biochemistry
Topic: Cellular oxidation

Q 30. Cellular oxidation is inhibited by:
A. Cyanide
B. Carbon dioxide
C. Chocolate
D. Carbonated beverages

For answers and more details please click: http://bit.ly/1jX6rku
1
Add a comment...
People
Have her in circles
107 people
Rakesh Jha's profile photo
Nuéng Jirawat (Jee)'s profile photo
Kaplan Medical Licensing USMLE & COMLEX-USA Prep's profile photo
Soumitro Deb's profile photo
Jackson Walt's profile photo
arjun mehndiratta's profile photo
Shashir Meshram's profile photo
Tushar Motghare's profile photo
Ema Rickijevic's profile photo
Work
Occupation
Doctor
Employment
  • AIIMS
    Doctor
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
India
Story
Tagline
IndiaQBank is an online test preparation service for the medical and engineering exams of India. Our features, accuracy and expertise in question and case creation will give you the very best studying experience available
Introduction
                 
Welcome to IndiaQBank!

Come find out why we are the best.

IndiaQBank is an online test preparation service for the medical and engineering exams of India. Our features, accuracy and expertise in question and case creation will give you the very best studying experience available.

Thousands of medical and engineering students and physicians worldwide use IndiaQBank to help them prepare for NEET-PG, FMGE, USMLE1 and JEE MAIN. Please sign up and be on your way to passing these exams with the highest scores possible, or check out our free Demo QBanks.
Bragging rights
Free Access to Online Examinations till Dec 31st
Education
  • St Anns
    1985
Basic Information
Gender
Female