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David Wimble
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A RESTLESS LEGS SYNDROME SUCCESS STORY: Lynne Parrish, Sharon, PA

Hi everyone. It's been over 8 months since I posted. A lot of things have been going on. Mostly side-tracked with work.

There's not a lot of news on the RLS front. Nothing helpful anyway.
I'll get back into research mode soon.

In the meantime, I've just received a wonderful thank you letter from Lynne Parrish of Sharon, PA. I'd like to present it to you, to hopefully give you hope.

Here it is ...

I started my journey in July of 2013 after coming across David's article "An Absolute Cure for RLS"

What? I am 55 & have wrestled with this monster for about 30 years. Did I mention that I had tried everything except drugs? An absolute cure... I'm in. So with both feet and very restless legs, I jumped. I followed David's nutritional & supplemental plan pretty much to the letter for the first several months. At his suggestion, I downloaded the IF (Inflammation Factor) app onto my phone and entered everything that passed my lips religiously. It was my "teacher".

As I became more knowledgeable about the inflammation scores of various foods, I grew less & less dependent on the app. After completing a round of the supplements, I narrowed some things down to what I thought was working best for me.

One year later, I was almost symptom free, almost.

And another 2 years later, I was 57 and, quite frankly, my life had been redefined by the information that I stumbled across on David's website.

Now, I am not only symptom free (except when I get very tired) I have been practically symptom free for 2 years!

It only took 3 days to feel my first drop in inflammation. I was hooked. Then in 3 weeks I felt another drop and then again in 3 months. I don't know why, but I noticed the drops in 3's and when it occurred, it felt as though the race horses trapped on the inside of my legs were finally slowing down.

Nowadays, I still stay fairly conscience of my diet & a few "anti inflammatory tricks" are my daily companions. I begin every morning with 1/2-1 cup of carrot juice mixed with protein powder & a mixture of almond meal & ground flax seed. I have mostly replaced the rice, bread, and white potatoes with sweet potatoes, butternut squash, & all things orange. Salmon, sardines, & anchovies are staples.

And so, I tip my hat to you David. Blessings on you. I am ever so grateful.

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For more information on healing RLS, please visit www.rlcure.com
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RESTLESS LEGS, INFLAMMATION AND FOOD INTOLERANCE

This post features an excellent article by Dr. Mark Hyman on how food intolerance lead to inflammation, which in turn leads to a laundry list of "possible" medical conditions. This list includes Restless Legs Syndrome.

I say "possible" because in the world of inflammation, you never know exactly how it is going to manifest on the surface. For some it may be cancer, for others obesity, for many others depression.

There's probably not a medical condition that you can name that hasn't scientifically been proven to be a result of inflammation.

However, as I've stated many times before, because you suffer from RLS, you're kind of fortunate.

Just for a moment, if you can suspend the physical, mental and emotional torture of RLS, try to look at your restless legs as a friendly flair that your body is firing into the night sky, warning you about inevitable dangers that are forming inside your body.

Your restless twitchy legs are giving you a chance to take ACTION before a more life-threatening condition takes hold.

By trying to snuff out this flare with medication, instead of extinguishing it with a proper diet, you are in fact making a decision to NOT listen to your body.

To better illustrate the decision you're making, imagine that you're lying in bed and the smoke alarm goes off.

When the alarm goes off, you probably don't lie there and grumble about losing valuable sleep nor do you reach down and pull the sheets over your head in order to muffle out the sound.

You INSTINCTIVELY jump out of bed to find out what's going on.

If it turns out that there is a fire, you gather your family and run out of the house to safety.

If it was just your child making a late night snack, and it was burnt toast that set off the alarm, you can open a window and safely go back to bed.

But when that alarm first went off, all that you knew was that there was a potential life-threatening situation that needed IMMEDIATE action. There was no delay. You got out of bed and investigated RIGHT AWAY to see what had to be done.

Why then, when your body's smoke alarm goes off, do you ignore it?

I hope that Dr. Hyman's article will inspire you to take the steps required to start putting out the smouldering fire that has set off your smoke alarm.

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"INFLAMMATION: HOW TO COOL THE FIRE INSIDE You" by Mark Hyman, MD

HOW CAN YOU, IN a week or less, get dramatic relief from all the symptoms you thought you had to live with the rest of your life?

I’ll get to that in just a minute...

First I’m going to tell you about a hidden culprit that’s linked to everything from obesity to all the chronic diseases of aging. And I’ll give you the key to solving this problem — and unlocking good health.

Over the years, I’ve helped patient after patient achieve good health. But what I’ve asked patients to do is so simple that anyone can do it — and get the same great results.

I’m going to tell you about something I've talked about before, but it’s so important that I want to emphasize it again and show you how it’s a hidden cause of poor health.

I’m talking about inflammation.

You’re probably familiar with the pain, swelling, redness, and heat that classically signify inflammation. It’s something just about every one out there has experienced.

Inflammation is part of the body’s natural defense system.

When your body senses foreign invaders, a specific cascade of events is set off in which your white blood cells and some special chemicals called cytokines mobilize to protect you.

This normal type of inflammation is a good thing. It helps your body protect and heal itself. However, when your immune system shifts out of balance, inflammation can run rampant — causing a chronic, smoldering fire inside your body that contributes to disease.

The causes of this type of inflammation are all around you. The sugar you eat, high doses of the wrong oils and fats in your diet, hidden food allergens, lack of exercise, chronic stress, and hidden infections all trigger a raging, unseen inflammation deep in your cells and tissues.

And this inflammation leads to every one of the major chronic diseases of aging — heart disease, cancer, diabetes, dementia and more.  

It’s simple.

If you don’t address inflammation by eliminating hidden food allergens or sensitivities and by eating an anti-inflammatory diet, you will never succeed at effective and permanent health. Hidden sensitivities and allergies to food you eat every day are making you sick and are causing your legs to be inflamed.

When most people think of food allergies, they usually imagine someone eating a peanut and ending up in the emergency room with a swollen tongue, hives, and not being able to breathe. That’s what is called an immediate allergy (also known as an IgE hypersensitivity reaction). This is very serious but not common.

But there is a different type of reaction to foods that is much less dramatic and deadly — but still very troublesome. It is called a delayed allergy (or IgG delayed hypersensitivity reaction). This reaction is much more common and creates a lot of suffering for millions of people. It’s mostly ignored by conventional medicine, yet it plays a HUGE role in many chronic illnesses.

This type of delayed allergic reaction can cause symptoms anywhere from a few hours to a few days after ingestion. It also causes a wide range of problems like weight gain, fluid retention, fatigue, brain fog, irritable bowel syndrome, mood problems, headaches, sinus and nasal congestion, joint pains, acne, eczema, and more.

If you hear someone say dismissively, “Oh, you just lost water weight,” they’re right (at first), because eating foods you are allergic to causes inflammation, which leads to swelling and fluid retention.

Getting rid of this fluid by reducing inflammation is a GOOD thing, not a bad thing.  It is what will allow your body to start the healing process so you can achieve permanent weight loss and optimal health.

Consuming a low-allergy diet for just 1 week will help you eliminate the excess swelling and fluid that accumulates in your tissues from food-induced chronic inflammation. Despite criticisms you may have heard about losing ONLY water weight, this is essential for you body to begin to heal and detoxify.

Let me explain a little more.

In my practice, treating food allergies and improving nutrition in general is the single most powerful tool I have to treat, reverse, and even cure hundreds of diseases that conventional medicine fails at miserably.

These include allergies, arthritis, autoimmune diseases, fatigue, sinus problems, hormonal disorders, obesity, high blood pressure, cholesterol, digestive diseases like irritable bowel syndrome, reflux, and colitis, and even mood disorders like depression and anxiety — just to name a few.

You see, we are seeing an epidemic of inflammatory diseases. In fact nearly every modern disease — everything from autoimmune diseases, heart disease, and cancer to obesity, diabetes, and dementia — is caused by inflammation!

These chronic diseases affect 125 million Americans. That means in the average family of three, at least one person has a chronic disease caused by inflammation. In my practice, helping people treat food allergies and food sensitivities is one of the most helpful things I do.

So what have I found after years of testing people for IgG allergies and teaching them how to use elimination diets to help recover from their chronic symptoms and illnesses?

While everyone is different, there are some foods that irritate the immune system more than others.  They are gluten (wheat, barley, rye, oats, spelt, kamut), dairy (milk, cheese, butter, yogurt), corn, eggs, soy, nuts, nightshades (tomatoes, bell peppers1, potatoes, eggplant), citrus, and yeast (baker’s yeast, brewer’s yeast, and fermented products).

These foods can also cause acute allergic reactions. But those are rare, generally affecting less than 1 percent of the population. When they occur they are serious, permanent, and need to be treated seriously.

But for more than 50 percent of us, there are some foods that just don’t agree with us and prevent vibrant, good health.

How Do You Know If You Are Allergic or Sensitive to Foods?

There are two ways to find out if you are reacting to foods.

One is a blood test for IgG antibodies to foods. This is useful and can pinpoint trouble areas, but it is not 100 percent accurate.

The second is a simple and well-accepted treatment called elimination/ provocation.

This means you get rid of the top trouble foods for 1 to 4 weeks, then reintroduce them one at a time and see what happens. Eliminating foods that cause allergic reactions or sensitivities is the basis for the remarkable results people have — like losing weight, feeling better, and getting rid of chronic symptoms — when they follow the detox phase of UltraMetabolism: The Simple Plan for Automatic Weight Loss.

This program is based on a simple elimination diet: getting rid of gluten, dairy, eggs, and yeast products.

What happens?

Very quickly — in a week or less — people notice dramatic relief from all the symptoms they thought they had to live with the rest of their lives!

WHY DO YOU BECOME SENSITIVE OR ALLERGIC TO FOODS?

Simply put, your diet, the way you live, and the medications you take are to blame.

These things injure your gut.

They change the bacteria and damage the gut’s lining, which is the critical barrier that keeps your immune system from having to deal with all the garbage, toxins, and allergens inside your intestinal tract. This damage is called a leaky gut.

And so the food particles “leak” across the damaged barrier and your immune system (60 percent of which is right under that lining) starts to attack these partially digested food particles. That’s when you develop IgG food intolerances or allergies.

Let me recap.

When your gut is leaky, partially digested foods get exposed to your immune system, which then creates an abnormal response to something pretty normal — food. That creates many chronic health problems.

FINDING AND FIXING DELAYED FOOD ALLERGIES AND SENSITIVITIES

Just because you have a food allergy or intolerance doesn’t mean you have to suffer with it. In fact, there’s a lot you can do to deal with the problem, re-balance your system, and eliminate chronic symptoms.

Visit my website to find out how to identify food allergies and to discover the tools you need to begin to heal your gut and repair your digestive and immune systems.

When you do these things, you’ll be more resilient and able to tolerate a wider range of foods. The plan is designed to get you started on the road to finding and healing this common obstacle to health.

Just think about giving yourself the gift of a week long vacation for your body and soul. You might be surprised by what’s on the other side. You’ll be following the same simple program that I use with my own patients to eliminate food allergies.

I think you’ll find that the results are remarkable.

But I don’t want you to just believe what I am saying — I want you to prove it to yourself!

To your good health,

Mark Hyman, MD

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About Mark Hyman, MD
Mark Hyman, MD, believes that we all deserve a life of vitality—and that we have the potential to create it for ourselves. That’s why he is dedicated to tackling the root causes of chronic disease by harnessing the power of Functional Medicine to transform healthcare. He is a practicing family physician, an nine-time #1 New York Times bestselling author, and an internationally recognized leader, speaker, educator, and advocate in his field. He is the Director of the Cleveland Clinic Center for Functional Medicine. He is also the founder and medical director of The UltraWellness Center, chairman of the board of the Institute for Functional Medicine, a medical editor of The Huffington Post, and has been a regular medical contributor on many television shows including CBS This Morning, the Today Show, CNN, The View, the Katie Couric show and The Dr. Oz Show. www.drhyman.com

#restlesslegssyndrome
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MULTIPLE SCLEROSIS, RESTLESS LEGS AND THE AMAZING WORLD OF EPIGENETICS

INTRODUCTION
 
Dr. Terry Wahls is a clinical professor of medicine at the University of Iowa Carver College. She is an avid clinical researcher with over 60 peer-reviewed scientific abstracts, posters and papers to her name.

Several years ago Dr. Wahls suffered from debilitating MS (and at the same time suffered from Restless Legs Syndrome).

As a doctor/scientist, her empirical view of life pointed to the undeniable fact that there was not going to be a cure discovered for MS before her rapidly approaching demise.

This stark truth propelled Dr. Wahls to look at alternative healing methods. By experimenting with changes in diet and attitude, Dr. Wahls was able to cure herself. In fact there is a famous split photo of her (below) showing a BEFORE PICTURE of her sitting, almost lifeless, in a wheelchair, and an AFTER PICTURE, showing her riding her bicycle, full of life, light and vibrancy.

I have had several correspondences with her, and I can tell you that she is an amazing force. As is the case with a lot of people that have been to the "brink" she wants to give back - to help others in similar situations to become healthy again.

Because she is also a former RLS sufferer, Dr. Wahls was kind enough to publish one of my RLS articles in her newsletter last year.

Her story can not only help those that suffer from MS or Restless Legs, it can inspire anyone with ANY condition to shift towards a healthy and balanced life.

In this article (below) from her monthly newsletter, she talks about the wonderful world of epigenetics, and how we are NOT bound by our genes. In other words, saying that you're STUCK with RLS because you inherited the condition, just doesn't wash anymore. It's not reality. There is a LOT you can do to improve your condition, if you open your mind just a smidge.

THERE ARE NO HOPELESS CASES!

For more information on Dr. Wahl's amazing journey, please follow the link at the bottom of this article.

ARTICLE:

"DON'T BLAME YOUR FAMILY TREE" by Dr. Terry Wahls, MD.

"When you were diagnosed with multiple sclerosis, you might have been wise enough to ask your doctor about diet and what you could do yourself to reduce the symptoms and pain associated with MS. Unfortunately, most neurologists today would shrug off that question and tell you there is no evidence that diet makes any difference. Your physician probably told you that science doesn’t know why you developed MS. You and your physician probably just blamed your genes, and then moved on to talking about what immune-suppressing drugs you should take, in an effort to keep you as functional as possible for as long as possible.

The problem with relying only on immune suppression to treat MS is that our immune cells are vital to the proper functioning of our bodies and brains. All immune-suppressing drugs therefore also have a long list of side effects, ranging from mild to life-threatening. But more importantly, immune suppression does not address the reasons people develop MS or any other autoimmune condition. To effectively treat disease, we must confront the root cause of why the immune system has malfunctioned and begun attacking the brain.

The good news is that for most chronic diseases, including autoimmune problems like MS, the cause is likely 5% genetic and 95% epigenetic. That means the environmental factors are huge. There are thousands of studies that have linked improving health behaviors with better health outcomes, a decline in symptoms of chronic disease, and reduced need for medication to treat diseases like obesity, diabetes, heart disease, mental health problems, cancers, and autoimmunity. Addressing diet and lifestyle as I explain in my book is how to have the more of the health promoting genes turned on and the disease promoting genes turned off."
 
For more information on Dr. Wahls, her recovery and her protocol please visit: www.terrywahls.com  #restlesslegssyndrome
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"A LITTLE-KNOWN CAUSE OF RESTLESS LEGS SYNDROME" by Chris Kresser, M.S., L.Ac

Restless legs syndrome has been associated with numerous conditions involving systemic inflammation and immune dysregulation. (3) One review paper published in 2012 investigated health conditions that were reported to cause or exacerbate RLS symptoms, and found that 95% of the 38 different health conditions that were strongly associated with RLS have an inflammation or immune component. (4) These conditions include Parkinson’s disease, multiple sclerosis, ADHD, Alzheimer’s disease, Celiac disease, Crohn’s disease, rheumatoid arthritis, sleep apnea, diabetes, and depression.

As further evidence, an elevated blood level of C-reactive protein (a marker of systemic inflammation) has been associated with increased RLS severity. (5) A small crossover trial found that a hydrocortisone infusion, which reduces systemic inflammation, reduced RLS symptoms. (6)

Researchers have proposed three potential mechanisms to explain the association between RLS and inflammatory or autoimmune states: direct autoimmune attack on the nervous system; genetic factors that could predispose an individual to RLS and be triggered by inflammation or autoimmunity; and iron deficiency caused by inflammation, which I’ll talk more about below.

What to do: If your RLS is a symptom of underlying systemic inflammation or immune dysregulation, the goal should be to find and treat the root cause. As I’ve mentioned many times in the past, gut infections are often the culprit—even if you don’t have noticeable digestive symptoms—so get your gut tested.

If you already have a diagnosed inflammatory or immune condition such as those I mentioned above, the best first step you can take is to adopt a “low-inflammatory” diet and lifestyle. This means eating a nutrient-rich, low-toxin diet based on whole foods; getting enough sleep every night; prioritizing stress management; and incorporating regular movement into your day.

REFERENCES
3. "Increased prevalence of restless legs syndrome in patients with Crohn's disease." http://www.ncbi.nlm.nih.gov/pubmed/25951489
4. "Restless legs syndrome--theoretical roles of inflammatory and immune mechanisms." http://www.ncbi.nlm.nih.gov/pubmed/22258033
5. "Elevated C-reactive protein is associated with severe periodic leg movements of sleep in patients with restless legs syndrome." http://www.ncbi.nlm.nih.gov/pubmed/22750520
6. "Low-dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome." http://www.ncbi.nlm.nih.gov/pubmed/18443313

Chris Kresser, M.S., L.Ac is a globally recognized leader in the fields of ancestral health, Paleo nutrition, and functional and integrative medicine. He is the creator of ChrisKresser.com, one of the top 25 natural health sites in the world, and the author of the New York Times best seller, Your Personal Paleo Code (published in paperback in December 2014 as The Paleo Cure). You can read the full article here: http://chriskresser.com/4-little-known-causes-of-restless-legs-syndrome

#RLS
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ANOTHER SCIENTIFIC LINK BETWEEN RESTLESS LEGS SYNDROME AND INFLAMMATION

Below is an excerpt from an article titled "Inflammation and Pain Management with Magnesium" by Dr. Mark Sircus, Ac., OMD, DM (P), December 8, 2009

"According to the National Sleep Foundation approximately 70 million people in the United States are affected with sleeping disorders. Approximately 12 million Americans have Restless Legs Syndrome, a sleep and movement disorder characterized by unpleasant (tingling, crawling, creeping and/or pulling) feelings in the legs, which cause an urge to move in order to relieve the symptoms.  

'People with poor quality sleep or sleep deprivation exhibit increased levels of interleukin-6 (IL6), the chemical that causes inflammation throughout the body' (Redwine et al. 2000)."

The above excerpt is a short but effective overview of the way that Restless Legs Syndrome feeds off itself; ever increasing the stranglehold it has over each individual.

The original RLS-causing inflammation in your body could have been created because of a number of issues. It's  likely that diet is involved, but there are many other possible contributors such as lifestyle, environment & toxins, alcohol consumption, stress, pregnancy, aging etc.

Once the inflammation inside you reaches a level that causes your legs to start tingling ... a whole new (ugly) cycle begins!

The lack of sleep you begin to experience because of your wonky legs AS WELL AS the stress of the increasing frustration BOTH raise the existing inflammation level inside of you.

And, of course, as time goes on, it just gets worse. It's an ugly, ugly debilitating cycle.

Your sleep gets worse, the inflammation increases. Your stress gets higher, the inflammation increases. Your anger deepens, the inflammation increases.

Yes, all the while, the RLS-causing inflammation inside of you increases, raising your inflammation and RLS to new levels.  

THE SOLUTION:

Healing RLS requires a multi-pronged attack. You can't just take a pill and wish it all away.  Taking a prescribed medication expecting it to rid your RLS is like closing the door to a room that is on fire expecting the fire to die out.

The inflammation inside of you is going to continue to increase and manifest in other ways. (I explain how RLS is actually a warning signal from your body, on my website www.rlcure.com).

To rid yourself of RLS you need to:

1. Put a cork in where the inflammation is flowing into your life.

This means, first off, change your diet! Get the sugar, trans & saturated fats, gluten, alcohol, refined carbohydrates and MSG out of your life, as best you can. Give your body a chance to heal. It doesn't have to be forever, just give it some breathing room to heal itself.

It also means that you need to learn to calm down.

Meditation, relaxation exercises and yoga have all been clinically proven to lower inflammation levels.

I still believe that no one is beyond help when it comes to RLS and inflammation. Regardless of how hopeless you think your situation is, if you're willing to make necessary sacrifices and put in the work, you can be healed.

For some helpful tips on natural ways to put out the fire that's raging inside your body, please visit my website www.rlcure.com

#rls
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ACUPUNCTURE AND HERBS RELIEVE RESTLESS LEG SYNDROME (RLS) by HealthCMi: The Healthcare Medicine Institute

Acupuncture and herbs alleviate restless leg syndrome (RLS). Researchers tested two forms of treatments and the findings indicate that acupuncture combined with herbal medicine is both safe and effective for the treatment of RLS. The total effective rate for acupuncture plus herbs was 95.24%.  

Restless leg syndrome (a.k.a. Willis-Ekbom disease) is characterized by a need to move the legs. The symptoms are typically worse at night and tend to lessen upon movement. An uncomfortable feeling in the legs including aching, pulling, itching, and a crawling sensation are characteristic of RLS.

The etiology of RLS is often considered unknown in biomedicine, however, several causes and exacerbating factors are known. Iron deficiency is common among RLS sufferers and is correlated with restless leg syndrome. Peripheral neuropathy, diabetes, Parkinson’s disease, and kidney diseases are correlated with RLS. Pregnancy related RLS typically occurs in the third trimester and usually resolves approximately one month after delivery. Several types of medications are linked to RLS including certain antiemetics, antipsychotics, antihistamines, and antidepressants.

According to Traditional Chinese Medicine (TCM) principles, RLS is closely related to Zang-Fu organ imbalances, especially in the liver, heart, and kidneys. Treatment principles including balancing yin and yang, promoting qi and blood circulation, nourishing the spleen, dredging the sanjiao meridian, and regulating the du and ren channels.

Two forms of acupuncture were tested for efficacy: body style acupuncture, eye region acupuncture. Both forms of acupuncture proved effective. The body style acupuncture included needling of the following acupoints:

    Baihui, DU20
    Sishenchong, extra
    Fengchi, GB20
    Anmian, extra
    Shanzhong, REN17
    Shenmen, HT7
    Neiguan, PC6
    Xuehai, SP10
    Zusanli, ST36
    Sanyinjiao, SP6
    Taixi, KD3
    Taichong, LV3

Mild reinforcing and reducing techniques were applied to acupuncture needles of 0.5 to 1.0 inches in length. Stimulation was applied to elicit deqi. Needle retention time was forty minutes per acupuncture session. Ten acupuncture treatments were applied to each participant in a period between ten and twenty days. Eye region acupuncture was applied to the following eye micro-acupuncture points: xiaojiao, liver, kidney, heart. The same frequency of treatment and session duration applied to the eye micro-acupuncture protocol of care.

Herbal medicine was given to participants receiving either type of acupuncture. The herbal formula was based on Jia Wei Xiao Yao Tang and additional herbs were added based on diagnostics. The base formula included:

    Mu Dan Pi
    Zhi Zi
    Fu Ling
    Bai Zhu
    Dang Gui
    Bai Shao Yao
    Bo He
    Gou Qi Zi
    Ju Hua
    Shu Di Huang
    Shan Yao
    Shan Zhu Yu
    Ze Xie
    Bai Ji Li
    Zhen Zhu Me
    Gui Ban
    Quan Xie
    Zhi Me
    He Huan Pi
    He Shou Wu

Additional herbs were added based on two criteria. For patients with loose stool and undigested food, Chen Pi and Bai Bian Dou were added. For patients with sticky stool, herbs were added and subtracted from the formula. Gou Qi Zi, Shan Yao, and Shan Zhu Yu (Shan Yu Rou) were supplanted with Che Qian Zi, Huang Lian, and Mu Xiang. The herbal formulas for all patients were brewed each day and served in the morning and at night.

The high total effective rate of 95.24% for acupuncture plus herbal medicine treatments indicates that this approach to care is effective for patients with RLS. Acupuncture continuing education research focusing on additional TCM (Traditional Chinese Medicine) protocols of care will help to codify acupuncture and herbal medicine standards. The influences of du, taiyang, and shaoyang channel blockages on restless leg syndrome are important factors according to TCM principles. Qi and blood stasis affecting these channels due to disorders such as lumbar disc compression, IVF (intervertebral foramina) encroachment, immobility of the sacroiliac joint, and other local concerns affecting acupuncture channels of the legs warrants additional research.


References:
"Eye acupuncture and combined acupuncture and medicine in the treatment of 23 patients with restless legs syndrome." Qin HJ. (2014). World Latest Medicine Information. 14(36).

"Restless legs syndrome categorization, diagnosis and treatment." Wang XD. (2006). Chinese Journal of Geriatrics. 25(7): 488-490.



You can read the full article here:

HealthCMi
http://www.healthcmi.com/Acupuncture-Continuing-Education-News/1576-acupuncture-and-herbs-relieve-restless-leg-syndrome-rls

#RLS
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"A LITTLE-KNOWN CAUSE OF RESTLESS LEGS SYNDROME" by Dr. Della Parker

Systemic Inflammation and Immune Dysregulation

Restless legs syndrome has been associated with numerous conditions involving systemic inflammation and immune dysregulation. One review paper published in 2012 investigated health conditions that were reported to cause or exacerbate RLS symptoms, and found that 95% of the 38 different health conditions that were strongly associated with RLS have an inflammation or immune component. These conditions include Parkinson’s disease, multiple sclerosis, ADHD, Alzheimer’s disease, Celiac disease, Crohn’s disease, rheumatoid arthritis, sleep apnea, diabetes, and depression.
As further evidence, an elevated blood level of C-reactive protein (a marker of systemic inflammation) has been associated with increased RLS severity. (5) A small crossover trial found that a hydrocortisone infusion, which reduces systemic inflammation, reduced RLS symptoms.
Researchers have proposed three potential mechanisms to explain the association between RLS and inflammatory or autoimmune states: direct autoimmune attack on the nervous system; genetic factors that could predispose an individual to RLS and be triggered by inflammation or autoimmunity; and iron deficiency caused by inflammation, which I’ll talk more about below.
What to do: If your RLS is a symptom of underlying systemic inflammation or immune dysregulation, the goal should be to find and treat the root cause. As I’ve mentioned many times in the past, gut infections are often the culprit—even if you don’t have noticeable digestive symptoms—so get your gut tested.
If you already have a diagnosed inflammatory or immune condition such as those I mentioned above, the best first step you can take is to adopt a “low-inflammatory” diet and lifestyle. This means eating a nutrient-rich, low-toxin diet based on whole foods; getting enough sleep every night; prioritizing stress management; and incorporating regular movement into your day.
You can also check out the bonus chapter about autoimmune disease from my book, as well as explore other information on my site about reversing autoimmune disease, the autoimmune protocol, the role of the microbiome, and alternative therapies such as LDN.
You can read the entire article here:
http://www.drdellaparker.com/3-little-known-causes-of-restl
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Dr. Della Parker, a naturopathic doctor, was born and raised in Portland, Oregon. She graduated from Portland State University with a Bachelor of Science. She then went on to graduate from the National College of Naturopathic Medicine, also in Portland, Oregon. Dr. Della has struggled with health problems throughout her life. Severe asthma and eczema as a child led her down a path of chronic steroid use, which led to many other health problems. It wasn’t until she took a job as a receptionist at a holistic health clinic that she realized how health care could be different. Making basic changes to diet and lifestyle as well as being treated with the holistic model of health, she was able to regain and take control of her health. This experience put her on the path of becoming a Naturopathic Physician. Most conventional doctors use a “cookbook” approach to treating patients. They use protocols to treat diseases while disregarding the host. This takes the functioning of the individual’s body out of the equation. Dr. Della rejects this idea and instead uses a holistic approach to treatments. Using the holistic model means that the whole person is addressed. For example, ten different patients could present with high cholesterol. They each may receive a different treatment recommendation based on the functioning of their whole body. www.drdellaparker.com

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A JAPANESE STUDY HAS FOUND AN ASSOCIATION BETWEEN RESTLESS LEGS SYNDROME AND INFLAMMATION

Dr. Terumi Higuchi of the Department of Nephrology, Keiai Hospital, Tokyo Japan, headed a recent study to determine if there was an association between RLS, oxidative stress and inflammation in patients undergoing hemodialysis.

The results of the study were published in the August 2015 edition of the "Sleep Medicine Journal" (Volume 16, Issue 8, Pages 941–948).

The study was called "Association of restless legs syndrome with oxidative stress and inflammation in patients undergoing hemodialysis"

In the HIGHLIGHT section of the study, Dr. Higuchi states that "Restless legs syndrome was associated with oxidative stress and inflammation."

You can read more details about the study here:
http://www.sleep-journal.com/article/S1389-9457%2815%2900746-7/abstract?cc=y=

#RestlessLegsSyndrome
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A TURKISH STUDY REVEALS THAT THERE IS A LINK BETWEEN RESTLESS LEGS SYNDROME AND INFLAMMATION

Dr. Tezcan Kaya works in the Department of Internal Medicine at Sakarya University in Adapazar, Turkey. He headed a study that was recently published in the May 29, 2015 edition of the Japanese journal “Therapeutic Apheresis and Dialysis”

The article was called “Relationships Between Malnutrition, Inflammation, Sleep Quality, and Restless Legs Syndrome in Hemodialysis Patients.”

Unfortunately for him, the study didn’t turn up the link he was hoping to find between malnutrition and RLS in Hemodialyis patients.

However he did state in the article that “RLS severity is correlated with inflammatory parameters.”

In non-medical terms, what he’s saying is that “when there is a higher degree of inflammation, there tends to be a higher degree of RLS.”

This completely falls in line with the formula I’ve been hitting people over the head with for the last several years:

   “LESS INFLAMMATION = LESS RLS.”

Hopefully someone will pick up on Dr. Tezcan’s findings and do some further testing.

You can read the abstract from the study here:
http://www.ncbi.nlm.nih.gov/pubmed/26031339


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A WAYNE STATE STUDY IS TESTING THE EFFECTS OF TOCOTRIENOLS (FROM PALM OIL) ON RESTLESS LEGS SYNDROME

INTRODUCTION:

For many years I've waited with great hope that some day there would be a study to test the effectiveness of a natural anti-inflammatory on patients with RLS. Today, I'm extremely excited to announce that dream is coming true!

The article below gives details on a study that is underway that is going to test the effect of powerful anti-inflammatories called "Tocotrienols" on End-Stage Renal Disease (Kidney Disease) and at the same time they are going to measure its effect on Restless Legs Syndrome.

After the article I have posted some details on what Tocotrienols are, and how their anti-inflammatory benefits have tested in regard to other medical conditions.


THE STUDY:

"A team of researchers led by Pramod Khosla, Ph.D., associate professor of nutrition and food science in the College of Liberal Arts and Sciences at Wayne State University, will study the effects of a daily supplement of a Tocotrienol-rich fraction from palm oil to see if it improves dyslipidemia, a disorder of lipoprotein metabolism that may be manifested by a decrease in the "good" high-density lipoprotein (HDL) cholesterol in patients with ESRD who are on hemodialysis. Tocotrienols are a form of Vitamin E and have been shown in recent years to have diverse health effects. In addition, Khosla's team will explore the impact on symptoms such as inflammation and symptoms related to Restless Leg Syndrome in the same cohort of patients.

Khosla believes that the supplement will also act as an anti-inflammatory and antioxidant nutrient, leading to improved nutritional status, lipid profiles, and inflammatory and oxidative stress markers in the ESRD patients.

The three-year study, funded by a $2.4 million grant from the Malaysian Palm Oil Board, a premier government agency of Malaysia, will take place in multiple dialysis centers in the United States and Malaysia. The cross-collaboration will allow the investigators to evaluate differences in dietary patterns of 800 dialysis patients in the two countries. With the patient pool in Michigan of predominantly African Americans and Caucasians and the Malaysian cohort comprised of three distinct ethnicities - Malays, Chinese and Indians - the investigators hope to shed light on possible genetic and metabolic differences in the dialysis populations. Additionally, as a significant proportion of dialysis patients suffer from Restless Legs Syndrome -- an unpleasant tingling or cramping sensation that impacts the quality of life -- the investigators hope to shed some light on the underlying causes for the condition.

"End-stage renal disease patients undergoing chronic hemodialysis experience a higher risk of complications such as cardiovascular disease, dyslipidemia, Restless Leg Syndrome, insomnia and other health issues," said Khosla. "In this study, we hope to see significant improvements in various biomarkers that should help decrease some of these complications."

Dr. James Sondheimer, associate professor of medicine and chief of the Division of Nephrology and Hypertension at WSU stated "We hope to gain a better understanding of how tocotrienols, as substances with antioxidant and anti-inflammatory effects, affect clinical outcomes as well as metabolic parameters."

http://www.eurekalert.org/pub_releases/2015-07/wsu--wss071315.php
 

ABOUT TOCOTRIENOLS:

Tocotrienols are members of the vitamin E family. An essential nutrient for the body, vitamin E is made up of four tocopherols (alpha, beta, gamma and delta). Tocotrienols are potent gene regulators and modulators of many enzymes involved in human health, helping to quash the inflammation, glycation, and other processes that contribute to age-related diseases. Tocotrienols are increasingly being recognized for their potential roles in protecting against cancer, heart disease, stroke, diabetes, liver disease, neurodegenerative diseases, and even osteoporosis.

Tocotrienols are natural compounds found in select vegetable oils, including rice bran oil and palm oil, wheat germ, barley, saw palmetto, anatto, and certain other types of seeds, nuts, grains, and the oils derived from them. This variant of vitamin E typically only occurs at very low levels in nature.

In studies, Tocotrienols reduced plasma levels of C-reactive protein (CRP), which is both a marker of and a cause in the inflammatory response that damages heart and blood vessels. They reduce other inflammatory mediators such as cytokines.

Tocotrienols are potent antioxidants, which appear to reduce the oxidant-induced inflammation that contributes to bone loss.

Tocotrienols given to mice with pancreatic cancer significantly improved their survival. Only 10% of animals in the control group survived for the study period while 70% of those taking tocotrienols survived!1 Pancreatic cancer is a particularly fast-moving and lethal form of cancer, and this study presents a promising new treatment option. Beyond cancer, research is showing that tocotrienols have a place in reducing important risk factors for some of the most lethal chronic diseases. For example, tocotrienols have been found to promote new artery formation after a stroke, lower homocysteine levels, improve insulin sensitivity, protect vital brain circuitry, and even prevent bone loss.

In a study using rabbits, tocotrienol supplementation, after a high-fat diet, significantly lowered a host of markers of both inflammation and heart muscle damage.

Through studies, tocotrienols have been closely linked to neuroprotection through their potent antioxidant properties, as well as their ability to redirect the production of inflammatory molecules to non- or even anti-inflammatory actions.



SOURCES:
"Tocotrienol" Wikipedia  en.wikipedia.org/wiki/Tocotrienol "The Little-Known Benefits Of Tocotrienols" by Thomas Rosenthal www.lifeextension.com/magazine/2014/8/the-little-known-benefits-of-tocotrienols/page-01
Prasad K. Tocotrienols and cardiovascular health. Curr Pharm Des. 2011;17(21):2147-54.
Das S, Mukherjee S, Lekli I, et al. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Mol Cell Biochem. 2012 Jan;360(1-2):35-45. Nazrun AS, Norazlina M, Norliza M, Nirwana SI. The anti-inflammatory role of vitamin e in prevention of osteoporosis. Adv Pharmacol Sci. 2012;2012:142702.
Nizar AM, Nazrun AS, Norazlina M, Norliza M, Ima Nirwana S. Low dose of tocotrienols protects osteoblasts against oxidative stress. Clin Ter. 2011;162(6):533-8.
Muhammad N, Luke DA, Shuid AN, Mohamed N, Soelaiman IN. Two different isomers of vitamin e prevent bone loss in postmenopausal osteoporosis rat model. Evid Based Complement Alternat Med. 2012;2012:161527.
Tiwari V, Kuhad A, Bishnoi M, Chopra K. Chronic treatment with tocotrienol, an isoform of vitamin E, prevents intracerebroventricular streptozotocin-induced cognitive impairment and oxidative-nitrosative stress in rats. Pharmacol Biochem Behav. 2009 Aug;93(2):183-9.
Kaileh M , Sen R. Role of NF-kappaB in the anti-inflammatory effects of tocotrienols. J Am Coll Nutr. 2010 Jun;29(3 Suppl):334S-339S.

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