Peripheral modifications of [Ψ[CH2NH]Tpg4]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics.

http://www.pnas.org/content/early/2017/05/23/1704125114.abstract

Light-sensitive E. coli paint a colourful picture. Microbes have been genetically engineered to sense red, green and blue light, and to produce pigment of the color that they sense (http://www.nature.com/news/light-sensitive-e-coli-paint-a-colourful-picture-1.22026?WT.mc_id=TWT_NatureNews&sf80775303=1).


How-to in UGENE: How to get the coverage table for an assembly?
When you analyze the NGS data, it would be useful to get the file with assembly coverage. For example, it can be used in further analysis or for calculating graphs and charts.
If you work only with one assembly, the easiest way for doing it is to use UGENE Assembly Browser:
1. Open an assembly file with UGENE (BAM/SAM file formats).
2. Open the context menu of the coverage chart and click “Export coverage”.
3. Choose the output file and parameters.
The documentation page about this feature: https://ugene.unipro.ru/wiki/display/UUOUM26/Exporting+Coverage
If you need to analyze a set of assemblies, it could be tediously to repeat all the actions for each assembly. It can be automated with UGENE Workflow Designer:
1. Open UGENE Workflow Designer and double click the “Extract coverage from assembly” sample of the NGS category.
2. Open the workflow wizard.
3. Choose files with assemblies (BAM/SAM file formats).
4. Set up the coverage settings: output file format, filtration threshold, etc.
5. Run the workflow.
The result files will contain the tab-delimited text that you can open, for example, with Excel.
Find the workflow documentation here: https://ugene.unipro.ru/wiki/display/WDD26/Extract+Coverage+from+Assembly

https://www.facebook.com/groups/ugene/permalink/1911329149136323/







Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.

https://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4345.html

Wellcome Trust Sanger Institute began to investigate whether or not it would be possible to use archived tumour samples from several decades ago. The oldest sequenced tumour sample to date was 32 years old, and while much older DNA has been sequenced in archaeological efforts, the samples do not afford the quality or breadth necessary for mutation detection. (http://www.frontlinegenomics.com/news/11919/sequencing-century-old-tumours/?utm_source=social%20media&utm_medium=social%20media&utm_campaign=social%20media)


Polyethylene bio-degradation by caterpillars of the wax moth Galleria mellonella.
http://www.cell.com/current-…/fulltext/S0960-9822(17)30231-2

Virus genomes reveal factors that spread and sustained the Ebola epidemic.

http://www.nature.com/nature/journal/v544/n7650/full/nature22040.html

23andMe, Inc. Granted First FDA Authorization to Market Direct-to-Consumer Genetic Health Risk Reports.
Mountain View, California – April 6, 2017 – 23andMe, Inc., the leading personal genetics company, today announced that the U.S. Food and Drug Administration (FDA) granted the company the first authorization to market genetic reports on personal risk for certain diseases. The authorization includes reports on genetic risk for ten conditions, including late-onset Alzheimer’s disease, Parkinson’s disease, celiac disease and hereditary thrombophilia (harmful blood clots), among others.

UGENE 1.26.0 has been released!

Changes in the release include:

1. All databases, supported by SnpEff, are now available for prediction of variant effects.

2. By default, all documents are opened in tabs instead of windows. To change this parameter go to the Application Settings.

3. Support of high-resolution Retina displays.

You can download the latest UGENE version on this page - http://ugene.unipro.ru/download.html.

A new view for working with Sanger reads – the Chromatogram Alignment Editor – is planned for 1.27 version. Stay tuned!