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KETAMIND
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"Ketamine has rapid-onset antidepressant action, although the mechanism of its positive effect is currently unclear, according to research published online Dec. 26 in the Journal of Clinical Pharmacy and Therapeutics.

Noting that the current pharmacotherapeutic treatment of major depressive disorder (MDD) can take weeks to be effective, Erin Drewniany, Pharm.D., from the Temple University School of Pharmacy in Philadelphia, and colleagues examined the role of ketamine as a more rapid-onset antidepressant."

http://www.doctorslounge.com/index.php/news/pb/52113

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Dr. Dennis Charney of Mount Sinai discusses recent research that shows that ketamine may be an effective treatment for depression in people who have been resistant to other treatments.

https://www.youtube.com/watch?list=PLE50FC91A844EEC33&v=5O_QDRLzW-o


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Results from a newly published study indicate that intranasal ketamine spray can produce a rapid and sustained antidepressant effect within 24 hours, and was well tolerated in a small group of patients with treatment-resistant major depressive disorder.

http://www.forbes.com/sites/robertglatter/2014/04/13/intranasal-ketamine-promising-for-treatment-resistant-major-depression/

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"Investigators found that among the 18 patients completing two treatment days with ketamine or saline, eight met response criteria to ketamine within 24 hours versus one on saline. Ketamine proved safe with minimal dissociative effects or changes in blood pressure."

http://psychcentral.com/news/2014/04/09/ketamine-nasal-spray-can-offer-quick-depression-relief/68278.html

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"A new study published this week in the Journal of Psychopharmacology found that approximately one-third of patients with what researchers referred to as "treatment-resistant depression" experienced a significant mood improvement after being treated with up to six intravenous ketamine infusions over the course of several weeks."

http://www.huffingtonpost.com/2014/04/05/ketamine-depression-study-oxford_n_5093201.html

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"Ketamine has proved an extremely effective treatment for depression, bipolar disorder and suicidal behaviour. It also works incredibly fast. Unlike conventional antidepressants, which generally take weeks to start working, ketamine lifts depression in as little as two hours. “It blew the doors off what we thought we knew about depression treatment,” says psychiatrist James Murrough at Mount Sinai Hospital in New York City."

http://www.nature.com/news/rave-drug-holds-promise-for-treating-depression-fast-1.16664

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"Doctors at the Mayo Clinic gave 10 patients ketamine twice a week as an infusion that lasted 100 minutes. All the people had depression that had resisted other treatments. The patients got ketamine until their symptoms abated or they'd had four infusions of the drug.

Half the people were pretty much free of symptoms of depression after treatment. And two of those people were still in remission a month afterward. The results were published in the Journal of Psychopharmacology."

http://www.npr.org/sections/health-shots/2013/06/06/189227349/can-ketamine-keep-depression-at-bay

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"Ketamine acts on a target in the brain where no other drug in psychiatry currently does: the NMDA receptor, which it blocks. The receptor is the site of action of glutamate, a neurotransmitter critically important in learning and memory — and, it turns out, in depression.

Several promising early studies found that depressed patients who had failed to respond to multiple antidepressants experienced rapid resolution of their symptoms within a few hours of ketamine infusion.

Unlike standard antidepressants, which typically take weeks to work, ketamine’s effect is rapid because its target, the NMDA receptor, is fast-acting."

http://www.nytimes.com/2013/08/20/health/a-dry-pipeline-for-psychiatric-drugs.html?_r=2

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Ketamine was developed as an anesthetic and received FDA approval for this use in 1970. Decades later, it became popular as a psychedelic club drug. And in 2006, a team from the National Institute of Mental Health published a landmark study showing that a single intravenous dose of ketamine produced "robust and rapid antidepressant effects" within a couple of hours.

http://www.npr.org/sections/health-shots/2015/09/28/443203592/club-drug-ketamine-gains-traction-as-a-treatment-for-depression

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"The results were presented at the annual meeting of the American Psychiatric Association and represent growing excitement about ketamine’s potential. The study included 72 patients who had previously failed to respond to at least two other medications. After receiving a single intravenous (IV) dose of ketamine, 64% of patients reported fewer depression symptoms within one day compared to 28% of those given midazolam — an anesthetic drug that was used as a control."

http://healthland.time.com/2013/05/22/club-drug-ketamine-lifts-depression-in-hours/
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