This is when we start noticing that the world has fundamentally changed. Someday there will be a majority of people who are orders of magnitude more intelligent than the current average person.
These new people won't be limited to phenomenal mental calculations; their very nature will ensure things like stronger bones, perfect teeth, bullet-proof skin and un-rippable ligaments and tendons.
They will look at us with pity, I hope; but probably never as equals. Would we be that generous to a neaderthal that had learned to communicate? Our history with great apes that sign to communicate tells a pretty depressing tale.
Our destiny is upgrade or be left to irrelevance. Make no mistake: a people that can learn a language in a week, complete current level college degrees by age 10, never experience colds or flues and are immensely physically strong will have precious little need for the current crop of average people. What the future has in store is so different to anything before that it is the redefinition of what it means to be a human. We are a steam boat being overtaken by a satellite. I hope we can change with them.
Whether or not we go there, we need to recognize that procreation is competitive. Giving your progeny every chance to succeed is laudable. Where to stop is going to be the debatable issue. Shouldn't your child be screened for Down's Syndrome? What about dwarfism? Huntington's Disease for sure, right?
What happens when the majority say: I want my kid to have an "enhanced" body, a "superior" intellect and long life?