I have difficulty drinking in large quantities, yet drink moderately, regularly. So maybe I am biased in my reaction, but I expect that I have the gene in question, and I view my drinking as probably best done without or less, but not having a major impact on my health either way.
Not being able to binge drink is surely a positive for heart health. And those who drink very large amounts but still eat a typical diet are likely to gain weight faster, and keep it on more persistently, than people who eat the same diet but don't add all those extra calories, as one example of an uncontrolled variable in this study. Did they control for things like weight gain over a long-ish period of time (say, decades) for all those who drank, had the gene, and the ones who didn't have the gene? What about other factors? Did the light drinkers typically exercise more? Was the gene in question evenly distributed in the population? Or concentrated in areas where heart disease is already less widespread?
Or there may be another effect of the gene in question, unrelated entirely to alcohol, that protects the heart or reduces LDL cholesterol & triglycerides.
I wish we didn't view this as a given food or drink has to be A. killing you! Abstain! ; or B. You MUST eat/drink this to say healthy--and all the time. We tend towards a pretty stupid binarism in looking at these things.
All we can be sure of with alcohol is that it affects driving ability, lowers inhibitions, and excessive consumption is bad for overall health, weight and brain function. And anyone who regularly drinks to total drunkenness is at risk of alcoholism, especially when they start young (pre-18). A disease of addiction that is terrible for health and just about everything else.
Beyond that, all that's pretty established scientifically to a fairly high standard of proof is that if you are having 4 or more drinks every day for men, or 2-3 and more for women; or drinking 1.5 to 3x that in binges every week or twice each week, you should be aware that it isn't healthy, and as you get older, it is quite bad for you. And if you are overweight, and/or have high cholesterol, or have a family history of heart disease, it may be healthier not to drink alcohol at all. But the evidence is not compelling yet in either direction.
Given the backpedaling that has been made recently on eggs, say (now it's widely believed we DON'T absorb egg cholesterol at all or nearly at all--so they don't give us high cholesterol ) and so many other things food & health related in the past 75 years, maintaining a healthy skepticism that we really know anything reliable about how healthy or unhealthy moderate or light drinking is seems the "moderate" point of view to stick to, doesn't it?
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