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Quantitative Proteomics
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Quantitative Proteomics

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This series of posts today are references to some of our recent publications
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Quantitative Proteomics

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Yang, Wan S., SriRamaratnam, R., Welsch, Matthew E., Shimada, K., Skouta, R., Viswanathan, Vasanthi S., Cheah, Jaime H., Clemons, Paul A., Shamji, Alykhan F., Clish, Clary B., Brown, Lewis M., Girotti, Albert W., Cornish, Virginia W., Schreiber, Stuart L., and Stockwell, Brent R. 2014. Regulation of Ferroptotic Cancer Cell Death by GPX4. Cell 156(1-2): 317-331.
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Nathan J. Weyand, Anne M. Wertheimer, Theodore R. Hobbs, Jennifer L. Sisko, Nyiawung A. Taku, Lindsay D. Gregston, Susan Clary, Dustin L. Higashi, Nicolas Biais, Lewis M. Brown, Shannon L. Planer, Alfred W. Legasse, Michael K. Axthelm, Scott W. Wong, Magdalene So. 2013. Neisseria infection of rhesus macaques as a model to study colonization, transmission, persistence and horizontal gene transfer. Proc Natl Acad Sci U S A. 110: 3059-3064. PMID: 23382234; PMC3581930.
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Allyson K Martinez, Emily Gordon, Arnab Sengupta, Nitin Shirole, Dorota Klepacki, Blanca Martinez-Garriga, Lewis M. Brown, Michael J. Benedik,  Charles Yanofsky, Alexander S. Mankin, Nora Vazquez-Laslop, Matthew S. Sachs, Luis R. Cruz-Vera, 2013. Interactions of the TnaC nascent peptide with rRNA in the exit tunnel enable the ribosome to respond to free tryptophan. Nucleic Acids Research Vol. 42: 1245–1256
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Quantitative Proteomics

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Jin Yang, Yao Li, Lawrence Chan, Yi-Ting Tsai,Wen-Hsuan Wu,
Huy V. Nguyen, Chun-Wei Hsu, Xiaorong Li, Lewis M. Brown, Dieter Egli,
Janet R. Sparrow and Stephen H. Tsang. Validation of genome-wide association study (GWAS)-identified disease risk alleles with
patient-specific stem cell lines. Human Molecular Genetics, 2014 Advance Access published February 18, 2014
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Alegre-Aguaron, E., Sampat, S.R., Xiong, J.C., Colligan, R.M., Bulinski, J.C., Cook, J.L., Ateshian, G.A., Brown, L.M., and Hung, C.T. 2014. Growth Factor Priming Differentially Modulates Components of the Extracellular Matrix Proteome in Chondrocytes and Synovium-Derived Stem Cells. PLoS ONE 9(2): e88053.
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Federica Parisi, Sara Riccardo, Sheri Zola, Carlina Lora, Daniela Grifoni, Lewis M. Brown, Paola Bellosta.  2013. dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth. Dev. Biol. 379:64-75 PMID: 23608455; PMC3712331.
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Deborah Moran, Trevor Cross, Lewis M. Brown, Ryan M. Colligan, David Dunbar. 2013. Data-independent acquisition (MSE) with ion mobility provides a systematic method for analysis of a bacteriophage structural proteome. Journal of Virol. 195:9-17
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Quantitative Proteomics

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Typical result of large-scale protein profiling experiment.
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i have the raw data ..
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A Collaborative Laboratory at Columbia University
Introduction
The focus of the Quantitative Proteomics Center is the identification of proteins with differential quantitative expression in cells, tissues or in affinity purifications, and we have applied this technique employing mass spectrometry to many different research problems. We do projects with groups across all campuses of Columbia University and at other institutions across the nation. All internal and external research groups are treated equally.

Contact us to discuss your project.