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Jacob Scott
Works at H. Lee Moffitt Cancer Center
Attends University of Oxford
Lives in tampa,fl
1,925 followers|332,742 views
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Tagline
A radiation oncologist interested in theoretical modeling of cancer.
Introduction
I approach the understanding of cancer like my original training in physics taught me - from the ground up, using the descriptive language of mathematics.  Using established mathematics in new ways, guided by the principles of evolution, I hope to better understand (and maybe treat!) cancer.  I am a proud member of the Integrated Mathematical Oncology group at the Moffitt Cancer Center and the Centre for Mathematical Biology at Oxford University.

Follow me here or on twitter @CancerConnector and check out my blog 

Bragging rights
My 4 year old daughter knows the difference between rhyme and alliteration.
Education
  • University of Oxford
    Mathematical Biology, 2011 - present
  • United States Naval Academy
    Physics, 1994 - 1998
  • Old Dominion University
    Engineering Management, 2001 - 2003
  • Case Western Reserve University School of Medicine
    Medicine, 2004 - 2008
Basic Information
Gender
Male
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Networking
Relationship
Married
Work
Occupation
Physician Scientist in training
Employment
  • H. Lee Moffitt Cancer Center
    Radiation Oncology Resident, 2009 - present
  • US Navy
    Junior Officer, 1998 - 2003
  • Duval County Public Schools
    Physics Teacher, 2003 - 2004
  • University Hospitals Case Medical Center
    Intern, 2008 - 2009
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
tampa,fl
Previously
cleveland,ohio - jacksonville,fl - stonington,ct - isle-au-haut,me - chagrin falls, oh - charleston,sc - oxford, england - annapolis, md

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Called. Left a message. It's legit.

ELECTORAL ACTION ALERT: Leave a message at the U.S. Attorney General's office at 202-514-2000 (Comment line...press 4).
Keep it short: Name, US Citizen, where you reside, and demand that "The Electoral College vote be postponed until a full investigation of Russian interference and the Trump campaign's potential coordination with Russia is complete."
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Optimal structure of heterogeneous stem cell niche: The importance of cell migration in delaying tumorigenesis Leili Shahriyari, Ali Mahdipour Shirayeh doi: http://dx.doi.org/10.1101/082982 This article is a preprint and ha...
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First experimental evolution in cancer paper from #theorydivision  
Drug resistance remains an elusive problem in cancer therapy, particularly with novel targeted therapy approaches. Much work is currently focused upon the development of an increasing arsenal of targeted therapies, towards oncogenic driver genes such as ALK-EML4, to overcome the inevitable resistance that develops as therapies are continued over time. The current clinical paradigm after failure of first line ALK TKI is to administer another drug ...
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Thanks for this Philip. I don't know how many times I have been asked, during the course of my graduate studies, when I present what I think is new biological insight from old maths - 'where is the new math?' and vice versa. I think asking for both is not sensible.
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I forgot to share this this when it was hot off the press, but last week +David Basanta, +Jacob Scott, +Robert Vander Velde, and I released our latest preprint on the evolutionary games of cancer.

Here we introduce the double goods game for modeling acidity as a public good for all cancer cells, and oxygen from vasculature as a club good for non-glycolytic cancer cells. In this preprint, we focus on the case of linear goods, showing that our game has an internal equilibrium that one might not expect from previous analyses of the games in isolation. The dynamics in this case are (almost) identical to the optional public goods game (with the glycolytic cells as loners, and the slope of the acidity benefit function as their reward). The three possible dynamics regimes also have important consequences for treatment, in particular when it comes to scheduling concerns like timing, duration, and order.

If you prefer blog posts then this recent post has an overview of much of the content of the paper:

https://egtheory.wordpress.com/2016/07/14/double-goods-dex/

If you still don't feel comfortable citing blog posts in your papers, but wanted to cite some of my work from TheEGG, then look at the appendices of this recent paper. What you want to cite might be there.

For those that prefer arXiv to the bioRxiv: http://arxiv.org/abs/1608.00985

If you have any comments on the work then please let me know. Either in the comments here, on the blog, or through email.
Background: Tumours are diverse ecosystems with persistent heterogeneity in various cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and reprogramming of energy-metabolism for aerobic glycolysis. This heterogeneity has consequences for diagnosis, treatment, and disease progression. Methods: We introduce the double goods game to study the dynamics of these traits using evolutionary game theory. We model glycolyti...
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A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study
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Jacob Scott

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Optimal structure of heterogeneous stem cell niche: The importance of cell migration in delaying tumorigenesis Leili Shahriyari, Ali Mahdipour Shirayeh doi: http://dx.doi.org/10.1101/082982 This article is a preprint and ha...
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Collateral sensitivity networks reveal evolutionary instability and novel treatment strategies in ALK mutated non-small cell lung cancer. View ORCID ProfileAndrew Dhawan, Daniel Nichol, Fumi Kinose, View ORCID ProfileMoham...
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Today on #TheEGG, I built a minimal model of treatment resistance that allows for the benefit of drug holidays. Might be of interest to +Alexander Anderson, +David Basanta, +Jacob Scott, and +Robert Vander Velde.

Apparently, this is my 200th post on TheEGG (of a total of 239) and it comes the day after the blog turned 5 years old!
A couple of weeks ago, before we all left Tampa, Pranav Warman, David Basanta and I frantically worked on refinements of our model of prostate cancer in the bone. One of the things that David and P…
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Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature Artem Kaznatcheev, Robert Vander Velde, Jacob G Scott, David Basanta Abstract Background: Tumours are diverse ...
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new #cancer  research using #gametheory
 
Read here our latest EGT work with +Artem Kaznatcheev , +Robert Vander Velde  and +Jacob Scott 
Background: Tumours are diverse ecosystems with persistent heterogeneity in various cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and reprogramming of energy-metabolism for aerobic glycolysis. This heterogeneity has consequences for diagnosis, treatment, and disease progression. Methods: We introduce the double goods game to study the dynamics of these traits using evolutionary game theory. We model glycolyti...
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Great zoo. Well planned. Happy animals and happy families.
Public - 8 months ago
reviewed 8 months ago
Public - 11 months ago
reviewed 11 months ago
4 reviews
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Love this place! If you need after school care that goes the extra mile, then this is the best in South Tampa. They pick up from the school by bus, give them a snack, get their HW done, and they're open until 6. Teachers, not just babysitters, and they also do private tutoring if you need.
Public - 2 years ago
reviewed 2 years ago