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Jacob Scott
Works at H. Lee Moffitt Cancer Center
Attends University of Oxford
Lives in tampa,fl
1,727 followers|244,237 views
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Jacob Scott

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Implications of the hybrid epithelial/mesenchymal phenotype in metastasisMohit Kumar Jolly, Marcelo Boareto, Bin Huang, Dongya Jia, Mingyang Lu, Jose N Onuchic, Herbert Levine, Eshel Ben-Jacob(Submitted on 27 May 2015)Underst...
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Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity Bartlomiej Waclaw , Ivana Bozic , Meredith E Pittman , Ralph H Hruban , Bert Vogelstein , Martin A Nowak   Most cancers in humans...
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A math heavy post at #TheEGG  thinking about multiple interacting public goods and cancer. This is part of my ongoing project with Robert Vander Velde, +David Basanta, and +Jacob Scott. I use the post to sketch part of our basic idea as if writing in an  #openscience  notebook.
Although I've spent more time thinking about pairwise games, I've recently expanded my horizons to more serious considerations of public-goods games. They crop up frequently when we are modeling ag...
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PhD position in applied mathematics with one of my favorite scientists +Philip Gerlee available!
The topic. The properties of many biological systems emerge through the interactions of their constituent components; the development from a single cell to a fully formed organism is the results of orchestrated interactions between millions of cells, and also disease states such as cancer emerge ...
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Measuring frequency dependent fitness
In a recent blog post at theEGG me and Philipp Altrock argued for caution when applying game theoretic models to cancer. One of our concerns was the difficulty of measuring selective advantage, which is not constant, but changes with the frequency of the ge...
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Jacob Scott

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I'm excited to read this new #preprint from +Arne Traulsen  and friends. I'm sure it would be of interest to  +Dan Nichol +Alexander Anderson +Alex Fletcher +Artem Kaznatcheev   as well as others...
Abstract: Studies of fixation dynamics in Markov processes predominantly focus on the mean time to absorption. This may be inadequate if the distribution is broad and skewed. We compute the distribution of fixation times in one-step birth-death processes with two absorbing states.
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Author Manuscripts - clarification of PLoS Comp Biol's policy
Just a quick post. I and some colleagues recently submitted one of our papers " Steering Evolution with Combination Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance " (which you can read a nice post on +Artem Kaznatcheev 's blog here) to ...
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Today on #TheEGG we have a guest post from Rob Noble. He discusses Simpson's and Peto's paradoxes and what they have to do with Tomasetti & Vogelstein's controversial "bad luck paper". In particular, Rob details a reanalysis of the cancer risk versus lifetime number of stem-cell divisions dataset that he made with a pair of his colleagues.

/cc +Alexander Anderson, +David Basanta, +Buddhini Samarasinghe, +Jacob Scott
Among the highlights of my recent visit to IMO were several stimulating discussions with Artem Kaznatcheev. I'm still thinking over my response to his recent post about reductionist versus operatio...
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Healing Art of Pathology
Many apologies for the long delay in writing, residency training has been weighing heavily on my creative time - but this is coming to an end! In the realm of more good news, on July 1st I will assume the post of Clinical Instructor here at the Moffitt Canc...
Many apologies for the long delay in writing, residency training has been weighing heavily on my creative time - but this is coming to an end! In the realm of more good news, on July 1st I will assume the post of Clinical Ins...
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We just published a paper on the effects of controlling inspired carbon dioxide during consecutive breathlessness challenges using respiratory loading.

Isocapnia can be used to reduce effects of PETCO2 fluctuations on BOLD response during respiratory loading, but the obligatory hypercapnia might then also alter dyspnoea perception. In this study, we observed a small increase in baseline (unloaded) unpleasantness during hypercapnia (at +0.6kPa), but none during loading (i.e. it is not additive). We observed no habituation effects with repeated trials (four consecutive days). In short, isocapnic respiratory loading can induce respiratory unpleasantness in a stable and FMRI-friendly manner, even in multi-session studies, but does not provide the additional benefit of increased unpleasantness for the participant at such a low level.

Also (on a more personal note), maintaining said hypercapnia manually is quite a task. Coffee should be consumed, focus should be applied, training is always good. 
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People
In his circles
269 people
Have him in circles
1,727 people
Fenja Sopko-Mach's profile photo
Qadir Bagirov's profile photo
Moureen Ayoub's profile photo
Newaj sharif Polash's profile photo
Robert Underhill's profile photo
Anoop Shekar's profile photo
martha vuulika's profile photo
Paul Sonnier's profile photo
richard peter's profile photo
Work
Occupation
Physician Scientist in training
Employment
  • H. Lee Moffitt Cancer Center
    Radiation Oncology Resident, 2009 - present
  • US Navy
    Junior Officer, 1998 - 2003
  • Duval County Public Schools
    Physics Teacher, 2003 - 2004
  • University Hospitals Case Medical Center
    Intern, 2008 - 2009
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Currently
tampa,fl
Previously
cleveland,ohio - jacksonville,fl - stonington,ct - isle-au-haut,me - chagrin falls, oh - charleston,sc - oxford, england - annapolis, md
Story
Tagline
A radiation oncologist interested in theoretical modeling of cancer.
Introduction
I approach the understanding of cancer like my original training in physics taught me - from the ground up, using the descriptive language of mathematics.  Using established mathematics in new ways, guided by the principles of evolution, I hope to better understand (and maybe treat!) cancer.  I am a proud member of the Integrated Mathematical Oncology group at the Moffitt Cancer Center and the Centre for Mathematical Biology at Oxford University.

Follow me here or on twitter @CancerConnector and check out my blog 

Bragging rights
My 4 year old daughter knows the difference between rhyme and alliteration.
Education
  • University of Oxford
    Mathematical Biology, 2011 - present
  • United States Naval Academy
    Physics, 1994 - 1998
  • Old Dominion University
    Engineering Management, 2001 - 2003
  • Case Western Reserve University School of Medicine
    Medicine, 2004 - 2008
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Love this place! If you need after school care that goes the extra mile, then this is the best in South Tampa. They pick up from the school by bus, give them a snack, get their HW done, and they're open until 6. Teachers, not just babysitters, and they also do private tutoring if you need.
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