Shared publicly  - 
I've seen this video before but this is the first time it is passed around on G+ (for me at least). I wrote up an annotated guide for the video for those who are not cell and molecular biologists want to know what's what in the video. I intended to post it in the original stream, but alas, it has been sort of taken over by religion/creationism chatter. So I am posting my annotation here. It does presume you know a bit about cell biology because I just don't have the space to define each term. If you want something explained further, just ask. I teach this stuff, after all. ;-)

Feel free to link and share if you know someone who might find the annotation useful.

0:08 to 0:10 – red and white blood cells in a blood vessel
0:11 to 0:22 – vesicle surface proteins (Rab(purple)-Tether(yellow)) making contact with destination membrane
0:23 to 0:30 – phospholipid bilayer cell membrane and islands of membrane-embedded proteins, illustrating the fluid mosaic model of membrane
0:31 to 0:41 – looking from inside the side, the cell cortex, which is a network of fibrous proteins that give structural support to the membrane
0:42 to 0:51 – either extracellular matrix or cell wall structure, going from outside towards to the cell
0:52 to 1:02 – polymerization of actin filament
1:03 to 1:05 – actin modifying enzyme that binds and cleaves the actin filaments
1:06 to 1:10 – polymerization of microtubule from tubulin units
1:11 to 1:14 – depolymerization of microtubules
1:15 to 1:28 – motor protein, either dynein or kinesin, that transports a vesicle (dark blue blob) along the network of microtubules. It “walks” on the microtubule “highway” of the cell while carrying a vesicle. The little stubs on the blue vesicle are the Rab proteins seen in 0:11
1:29 to 1:31 – the centrosome, with a pair of perpendicularly-arranged centriole, comes into focus. You can see that it is the organization center from which the microtubules originate.
1:32 to 1:39 – mature mRNA (the string) exported from the nuclear pores into the cytoplasm.
1:40 to 1:43 – beginning assembly of a translational complex
1:44: to 1:45 – assembly of the small, then the large, subunit of a ribosome
1:46 to 1:50 – translation of a protein that is destined to stay in the cytoplasm
1:51 to 1:56 – protein-protein interaction in the foreground, floating to a mitochondrion in the background
1:57 to 2:03 – translation by ribosome on the surface of the endoplasmic reticulum. The protein is translated directly into the lumen of the ER. These proteins are destined to be moved by vesicles.
2:04 to 2:08 – not sure
2:09 to 2:13 – motor protein again (1:15 to 1:28)
2:14 to 2:20 – vesicle fusion and protein sorting in the Golgi Apparatus
2:21 to 2:22 – motor protein
2:22 to 2:24 – exocytosis where a vesicle is fused with the cell membrane so that the content in the vesicle (blue blobs) are ejected. Some of the proteins are attached to the membrane and they now become part of the protein mixture on the cell membrane after exocytosis (golden color blobs).
2:24 to 2:37 – fluid mosaic model of membrane, with embedded proteins (0:23 to 0:30).
2:38 to 2:41 – extracellular domains of transmembrane proteins unfold
2:42 to 2:48 – red and white blood cells in a blood vessel
2:49 to 2:59 – white blood cell slipping through the epithelial layer of the blood vessel
2:59 to 3:05 – red and white blood cells in a blood vessel
임현조 (HyeonJo Im)'s profile photosegundo asensio's profile photoOlena Poskanna's profile photoAlejandra Palacios's profile photo
Really thank you Mr/ billy it's helped me to understand what's happened, because I'm not Scientist and I've a little information about science . thanks again .
I am a home educator and I have a 5th grader that is starting to get into the study of cells and the life of cells. Thank you for your run down for what all of this is, it will help me to teach it to her; with the visuals I am sure she will learn it better than I ever did!
Those annotations make all the difference if one wants to understand what one's seeing. Thanks!
This is absolutely fantastic! Thanks for sharing your knowledge about this. Show this to teenagers and I'm sure a lot of them would become instantly interested in molecular biology!
The video is beautiful, the walk-through was so appreciated.  Do I have to admit I still had to have my son, who has some bio background, add a little to the explanation :)
+Laurie Fish Yes some of the summary I gave can still be unpacked further, for sure. The animation illustrates a lot of biological principles!
I was watching it again and wondering about the speed of the processes we see in this video. +Billy Hung, do you the speeds of the interactions are realistic? I would like to know your opinion about it.
My biology teacher showed us this video and we were all fascinated . At first I can only figure out some of the details. Your annotate explain a lot, really appreciate it. Can I translate it into Chinese and share with my classmates for further discussion? I will tell them where it is from.
Add a comment...