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Carlos Esteban
Works at Venture Capital Fund in Barcelona
Attended Imperial College London
Lives in Barcelona
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Carlos Esteban

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Dubie Bacino originally shared to Macro Photography:
 
Robber Fly Portrait 5X - Photography by Javier Torrent
http://500px.com/photo/3017494 #macrophotography #robberfly #insects
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40 conferencias online gratis de #coaching ejecutivo y empresarial.

WBECS 2015: Congreso Mundial para Coaches Ejecutivos y Empresariales. Del 7 de mayo al 1 de julio de 2015.

http://guiadecoaching.com/wbecs-2015-congreso-mundial-para-coaches-ejecutivos-y-empresariales/
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El quinto Congreso Anual Mundial para Coaches Ejecutivos y Empresariales (WBECS 2015: World Business and Executive Coach Summit) tiene lugar del 7 de mayo al 1
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Your next smartphone screen could be BULLETPROOF: Scientists create tough see-through 'glass' made from metal

via +Jacqueline Lichtenberg 
Scientists at the US Navy Research Laboratory in Washington have developed a see-through armour from spinel, a mineral that contains aluminium and magnesium.
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I'd rather have that glass installed on my powersuit.  :)
But I'd really rather have a non-DailyMail link. This is the first one that came across my view:
https://plus.google.com/+WilcoRoos/posts/Ka4M1N57ySQ
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WTF, Evolution?!

I recently stumbled across what has become my favourite tumblr blog - WTF, Evolution?! http://wtfevolution.tumblr.com/ 

I like it because:

1. I get to be amazed by an extraordinarily diverse and baffling array of different creatures that I never knew could exist, let alone existed. 

2. The conversational commentary between the blogger and the "entity" that is evolution is pretty humorous at times :) E.g. criticising evolution for seemingly stupid design choices. 

* The latest entry on the comb duck reminds me of the bizarre head ornaments sported by the duck-billed dinosaurs. 

* An example of entries includes trap-door ants, penis-fencing flatworms, anus-dwelling pearlfish, sea-spiders with digestive organs in their legs. 

BUT IF YOU ONLY DO ONE THING TODAY: Watch the giant red leech having a meal: http://wtfevolution.tumblr.com/post/98726965887/wait-what-is-that-giant-red-leech-doing-is-it

#evolution   #wtf   #wondrous  
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muy bello_=
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Truly fantastic shot.
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Fantastik banget....
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SciTech #ScienceSunday Digest - 21/2015.
Permalink here: http://www.scitechdigest.net/2015/05/yeast-opiate-production-crispr-gmo.html

Yeast opiate production, CRISPR GMO killswitch, Optical computation, Continuous roll graphene, Cell periodic table, Immune evading implants, Wearable muscle sensor, Molecular pumps, Learning robots, Laser scanner. 

1. Engineered Yeast for Opiate Production
After a number of years of effort by multiple groups the final enzymatic synthetic step in the pathway for opiate production (morphine, etc) has been completed and it is now possible to create strains of yeast that produce opiate drugs as part of normal metabolism http://www.nature.com/news/drugs-regulate-home-brew-opiates-1.17563. With such a strain and basic fermentation skills morphine-producing yeast could be grown in a home-brew beer kit, but the original development was intended for cheaper, simpler, production of opiates. I disagree strongly with the alarmist commentary and propaganda around this, including this quote from the linked article “All told, decentralized and localized production would almost certainly reduce the cost and increase the availability of illegal opiates — substantially worsening a worldwide problem.” which I consider myopic; I believe this would substantially improve a worldwide problem. 

2. CRISPR-Based GMO Kill-Switch
CRISPR has now been employed in a novel way to trigger the removal and destruction of modified genes from genetically modified organisms and leaving the original genes intact http://www.theverge.com/2015/5/19/8625623/gmo-crispr-kill-switch-self-destructing-dna. It seems the system can kill the cells directly, inactivate or delete just the modified or introduced genes, or do both. Triggers for activating the system could include light levels, the presence or absence of a particular molecule - useful for controlling crops for example - and others. This seems to be similar in application to Terminator gene technology that was developed to limit the spread of GMO crops by preventing the growth of new seed, but in this case you would still get seed that could only be grow in desired areas. 

3. Optical Computing Developments
We had a trio of advances in optical computing this week. First, the smallest-ever silicon photonic beam-splitter has been demonstrated, designed by novel algorithms, measuring just 2.4 microns on a side, and promising faster on-chip communication and processing http://unews.utah.edu/news_releases/silicon-photonics/. IBM announces new CMOS integrated silicon nanophotonics technology and new chips designed to work alongside electrical chips while transferring data at 100 Gbps (full HD movie in 2 seconds), first application in high end servers and data centers http://www-03.ibm.com/press/us/en/pressrelease/46839.wss. Layers of 2D graphene and boron nitride allow controlled propagation of confined light pulses (within the layered sheets) when a voltage is applied to the graphene http://newsoffice.mit.edu/2015/tuning-light-waves-with-2-d-materials-0520

4. Continuous Roll Production of Graphene
A new continuous roll-to-roll production method for manufacturing large sheets of graphene and possibly other 2D materials https://newsoffice.mit.edu/2015/manufacture-continuous-rolls-graphene-0521. At a rate of 2.5cm per minute the sheets are uniform and high-quality single-layer graphene; faster rates, up to 20x, still produce coated sheets but these are lower-quality with defects. While the process doesn’t yet produce sheets equal to the best batch-processing methods, different applications will have different quality requirements. Further improvements should result in improved quality and production speed. In related news a new 60% - 70% graphene ink formulation allows 3D printing of robust structures that retain many of graphene’s useful properties and used these as custom tissue scaffolds seeded with stem cells http://www.mccormick.northwestern.edu/news/articles/2015/05/printing-3D-graphene-structures-for-tissue-engineering.html

5. Towards a Periodic Table of Cells
New microfluidics technology can efficiently isolate single cells from a sample for analysis and when combined with new technology for single cell genomic analysis via cataloguing the mRNA expression profile of single cells is leading to an explosion in data and new knowledeg about different cell types in different tissues http://www.technologyreview.com/news/537416/single-cells-analyzed-at-unprecedented-scale/. This has resulted in identifying cells never seen before and recent studies such as a survey of 466 individual brain cells as a step towards a full cellular brain atlas, and mapping thousands of cells from a mouse brain to identify 47 different types. This is inching towards a periodic table of cells and a complete cellular map for the human body and their functions. In related news microfluidic techniques can now squeeze (immune) cells and force the introduction of desired antigens into them in order to create better and more effective vaccines out of the patient’s own cells http://newsoffice.mit.edu/2015/cell-squeezing-device-vaccines-0522

6. Better Implants that Evade the Immune System
New studies indicate that the geometry of implanted devices significantly affects how the body and immune system will tolerate their presence http://newsoffice.mit.edu/2015/designing-better-medical-implants-0518. While the material is important their results suggest that larger, spherical devices are better able to maintain their function and avoid the buildup of scar tissue. 0.5mm spheres loaded with pancreatic islet cells to treat diabetic mice failed within a month, whereas 1.5mm spheres continued to function past six months. Similar performance improvement were observed in many materials and also in primates. This is a very interesting platform for introducing novel living biosensors and living drug factories into people. 

7. Wearable Muscle Sensors with MyoWare
A new muscle sensor designed to be temporarily stuck on to your skin above the muscle group that you want to use can be used to trigger commands in various electronic devices and is currently available via kickstarter http://www.coolwearable.com/myoware-muscle/. This is related to the Myo gesture control armband that I’ve been keen to try out and I’d be tempted to back the kickstarter myself if the device came with bluetooth and could interface with my phone. I’m looking forward to further miniaturisation that allows these sensors and their wireless transmitters to be implanted and to take higher resolution readings. 

8. Designing a New Molecular Pump
The first entirely artificial molecular pump has been designed in which molecules pump other molecules http://www.northwestern.edu/newscenter/stories/2015/05/nature-inspires-first-artificial-molecular-pump-.html. The pump works via simple chemical reactions, driving molecules step by step up higher energy states and away from a natural equilibrium. The basic architecture involves a ring-shaped molecule that moves along a molecular thread or chain, storing energy as it does so by moving multiple rings towards one end. An interesting research novelty for now the ultimate goal is to have these little molecular machines power nanoscale devices, muscles, and perhaps perform computational operations. 

9. Learning Robots & Machines with Complex Goals
New deep learning algorithms enable some robots to learn new tasks via trial and error without pre-programmed details about the environment http://newscenter.berkeley.edu/2015/05/21/deep-learning-robot-masters-skills-via-trial-and-error/. A variety of tasks were successfully tested including putting a hanger on a rack, assembling a toy, screwing a cap on a bottle, and others, with learning times averaging 10 minutes to 3 hours depending on the level of complexity. In related news a reinforcement learning approach has demonstrated game-playing software that is capable of creating a hierarchy of goals while working towards a delayed reward http://nextbigfuture.com/2015/05/keen-software-house-makes-ai-that-can.html

10. Non-Mechanical Laser Scanner
DARPA has demonstrated its SWEEPER technology for enabling drastically improved LIDAR applications http://www.darpa.mil/NewsEvents/Releases/2015/05/21.aspx. Unlike conventional LIDAR devices SWEEPER does not require mechanical components and instead exploits silicon-based on-chip optical phased array technology that can sweep a laser beam back and forth 100,000 times per second. This is expected to enable LIDAR systems that are drastically miniaturised and extremely low-cost. Given LIDAR systems in autonomous vehicles are one of the most expensive components in an autonomous vehicle the benefits for a diverse array of applications are immense. A future version of Project Tango could even have one of these devices. 

Archive: http://www.scitechdigest.net/2015/05/yeast-opiate-production-crispr-gmo.html 
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Resumen de la conferencia "Tú puedes dar un salto cuántico en tu negocio y en tu vida" del  Dr. Srikumar Rao, fundador de The RAO Institute, en WBECS 2015: C
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hiie how r u
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Genetic basis for Mosquito Bite propensity. 
Why do some people attract all the mosquitoes while others are lucky? 
The answer seems to be in the genes. Scientists comparing identical and fraternal twins have zeroed in a genetic basis for why some people are tastier for mosquitoes. They compared 18 pairs of identical twins and 19 pairs of fraternal twins to see if there was any preference by mosquitoes. While there was biased preference between fraternal twins, there was none for identical twins. #mosquitoes   #mosquitobite   #genetics  
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122716
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Super Trouper, +Carlos Esteban :)
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Apúntate a las actividades gratuitas de la Semana Internacional del Coaching!

Organizado por +International Coach Federation
#coaching  
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IV Semana Internacional del Coaching 2015

La IV Semana Internacional del #Coaching se celebra del 18 al 24 de mayo de 2015. Organizada por la ICF (International Coach Federation), cuenta con el lema “Aumentando la visibilidad, la comprensión y el impacto del coaching”.
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Chameleons are a distinctive and highly specialized clade of old world lizards. The approximately 180 species of chameleon come in a range of colours, and many species have the ability to change colours. Chameleons are distinguished by their zygodactylous feet; their very long, highly modified, rapidly extrudable tongues; their swaying gait; and crests or horns on their distinctively shaped heads.
http://en.wikipedia.org/wiki/Chameleon
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SciTech #ScienceSunday Digest - 13/2015.
Permalink here: http://www.scitechdigest.net/2015/03/nanoparticles-stimulating-neurons.html

Nanoparticles stimulating neurons, Nanotubes stimulating neurons, Bioprocessing aptamer hydrogels, Controlling circadian rhythms, Making CRISPR better, DNA nanofabrication, Festo’s insect robots, Magnetic heat & sound, Nanolasers & photonic guides, Plasma shielding. 

1. Stimulating Neurons with Gold Nanoparticles.
A promising new technique for precisely stimulating neurons has been developed that involves coupling gold nanoparticles to other molecules that specifically bind to neuronal sodium channels without blocking them http://news.uchicago.edu/article/2015/03/12/new-technique-uses-light-take-genetics-out-optogenetics. When irradiated with light of a specific wavelength the gold nanoparticles heat up and this causes the channels to open up and initiate a signalling cascade; antibodies were also used to bind the particles to different neuronal channels. The particles also remained bound to the cell surface and the neurons didn’t suffer reduced signalling efficacy after prolonged and repeated artificial activation. Referred to as optogenetics without the genetics, future applications might include artificial vision restoration. A very flexible platform with different nanoparticles perhaps responding to different wavelengths of light and so potentially allowing simultaneous addressable signals; I wonder if they can signal output in a similar fashion too? Other nanoparticles sensitive to radio waves have also been shown to open up the blood brain barrier http://www.nouvelles.umontreal.ca/udem-news/news/20150325-nanorobotic-agents-open-the-blood-brain-barrier-offering-hope-for-new-brain-treatments.html

2. Carbon Nanotube Fibers Interface with the Brain.
In related neuronal stimulation news, carbon nanotube fibers have been developed that allow for intimate two-way brain stimulation and measurement and have proven superior to metal electrodes http://news.rice.edu/2015/03/25/carbon-nanotube-fibers-make-superior-links-to-brain-2/. The fibers measure one quarter the width of a human hair, terminate at a functional tip about the width of a neuron, and are made by wet-spinning millions of carbon nanotubes together. The strength and conductivity of the fibers are certainly attractive, but what convinced the group to pursue this avenue was their flexibility, softness, and biocompatibility. The plan is to develop the platform into deep-brain-stimulation applications at first before exploring other possibilities. 

3. Bioprocessing with Hydrogels and DNA Aptamers.
A new microfluidic system comprises flexible fins capped with DNA aptamers that are embedded in a hydrogel able to respond to different stimuli https://www.seas.harvard.edu/news/2015/03/catching-and-releasing-tiny-molecules. When a biological solution is run through the chip, the aptamers bind to the target molecule they were designed for, and when the stimulus is applied the hydrogel moves the aptamers into a different environment to release the molecules; thus specific molecules can be quickly sorted and separated from a complex solution. The proof-of-concept involved pulling the thrombin enzyme from a mixture of proteins. The hydrogel can be made sensitive to temperature, light, electric/magnetic fields, ionic gradients, etc while the aptamers can be specifically targeted and respond to pH, temperature, and salt. Seems like a nice, modular, and extensible technology with lots of applications. 

4. Controlling Circadian Rhythms and Improving Sleep Cycles.
A couple of interesting studies this week provided insights into the control of circadian rhythms in the brain and improving sleep, a summary of both can be found here http://www.kurzweilai.net/neuroscientists-identify-key-cell-type-in-the-brain-that-controls-body-clock. First, a key group of neurons were identified in the suprachiasmatic nucleus that produce a signalling neuropeptide called neuromedin S, which is both necessary and sufficient for the control of circadian rhythms in the animal; this provides an interesting target to hack. Second, the latest evidence for artificial light, particularly blue light, having a negative impact on our sleep and health has been demonstrated and makes a strong case for limiting the exposure of such light before sleep. 

5. Increasing CRISPR Efficiency Eightfold.
A new development of the CRISPR genetic engineering system results in the system being eight times more efficient at inducing genetic modifications in cells https://www.mdc-berlin.de/44343169/en/news/2015/20150325-mdc_researchers_greatly_increase_precision. The advance was made possible by introducing genetic elements that inhibit one of two methods of DNA strand repair, which are (i) homology-directed repair in which introduced genetic elements contain flanking DNA used as a template to splice the cut, and (ii) non-homologous end-joining in which free DNA ends are joined without a template and tiny deletions occur. Basically, the new system inhibits (ii) from occurring and so making it far more likely that (i) will work to incorporate your genetic change of interest. In tests up to 60% of all cells were modified in one go with the new system, something that holds promise for effective and widespread somatic cell engineering at some point. 

6. DNA Origami & DNA Modular 3D Building Units.
DNA origami and DNA as a programmable molecular building material took another important step forward this week with a new approach to joining and modular 3D DNA building units by snapping together complementary shapes http://www.tum.de/en/about-tum/news/press-releases/short/article/32303/. This group has been a powerhouse in pushing DNA origami technology over the years. The new work programs DNA to self-assemble into 3D building blocks that are precisely shaped to fit together by incorporating the short-range binding mechanism known as nucleobase stacking that can snap multiple blocks together; currently the platform allows three different binding mechanisms to be used. The team used this platform to build micrometer sized filaments and nanoscale machines with moving parts, including nanoscale actuators able to switch or cycle between states orders of magnitude more often and more stably than any prior DNA origami technology. 

7. Festo Robotics Continue to Impress.
Festo is an incredible innovative company that continually produces amazing robots that have previously included a kangaroo, seagull, dragonfly, air jellies, and others. This week it showed off its latest insectoid additions, cooperative ant robots with 3D printed bodies and electronics are able to operate autonomously or work together to achieve goals, and truly elegant butterfly robots that really have to be seen to be appreciated http://spectrum.ieee.org/automaton/robotics/industrial-robots/festo-bionic-ants-and-butterflies - be sure to check the videos. In related robotics news a new Amazon contest hopes to spur faster and more efficient robotics automation in warehouses http://www.technologyreview.com/news/536086/amazon-robot-contest-may-accelerate-warehouse-automation/

8. Controlling Heat and Sound with Magnets.
Vibrations through 3D materials, known as acoustic phonons that propagate both heat and sound, have been shown for the first time to possess magnetic properties that allow them to be manipulated with magnetism http://spectrum.ieee.org/nanoclast/semiconductors/materials/for-first-time-reseachers-demonstrate-heat-and-sound-are-magnetic. In one proof-of-concept the team demonstrated they could reduce the amount of heat flowing through a semiconductor by 12%. Using the technique heat and sound waves can be steered magnetically, which is an interesting result and a new phenomenon to manipulate. But the experimental setup was precise and it isn’t obvious how immediate applications might be developed. 

9. Nanolasers and Photonic Guides.
One of the most efficient, easy to build, and compatible nanolasers ever build has been fabricated out of a monolayer sheet of tungsten diselenide atop a standard optical cavity base that is hoped to enable the device to more easily integrate and speed-up modern electronics http://www.kurzweilai.net/a-nanolaser-and-a-bendable-light-material-promise-to-speed-up-microelectronic-devices. Also, mentioned in the same article in related news is the fabrication of a 3D printed spatially-variant photonic crystal able to bend light around tight 90 degree corners without the losses that would occur in conventional fibers and other materials; yet another enabling photonic feature able to benefit improvements in modern electronics. 

10. Dynamically Generated Plasma to Dampen Shockwaves.
Boeing has developed (or at least filed a patent on) a technology able to dynamically generate plasmas able to mitigate or prevent damage from shockwaves caused by nearby explosive blasts for example http://spectrum.ieee.org/tech-talk/aerospace/military/boeing-files-patent-for-electromagnetic-arc-generator-to-protect-against-explosive-shockwaves. The system detects an explosion nearby and calculates when and where-from the shockwave will arrive, then uses an electromagnetic arc generator (and a LOT of energy) to heat a specific region of air in the path of the shockwave into a plasma able to attenuate or absorb the shockwave. Patents don’t get granted without demonstrating enablement and I do wonder if we’ll get to see this system successfully demonstrated. 

Archived: http://www.scitechdigest.net/2015/03/nanoparticles-stimulating-neurons.html
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+Carlos Esteban I'm happy to see you sharing more often in public recently.  Having gone through a period of several months when life and health concerns derailed me for a while, I noticed that it was very hard to get back into the rhythm of scanning the literature for topics and introducing and commenting on them again.  The loss of a desire to share and write was severe.  It was kind of a writer's block that I had never experience before.  I am getting back to it slowly -- not easy to get back to the focused and mindful and happy state of mind that was there just back in late October.  You pick out so many interesting topics and are really good at curating your point of view of what is interesting and important.
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Work
Occupation
Venture capital investment analyst.
Employment
  • Venture Capital Fund in Barcelona
    Venture capital investment analyst, 2012 - present
  • Genagen
    Coordinador, 2011 - 2012
  • Departamento de Biotecnología, IATA-CSIC
    Investigador predoctoral, 1998 - 2004
  • Departamento de Microbiología, Universidad de Erlangen-Nüremberg, Alemania
    Dos estancias cortas, 1999 - 2000
  • Cursos sobre Riesgos Biológicos y Químicos
    Docente a tiempo parcial, 2000 - 2004
  • UT Southwestern Medical Center, Dallas, USA
    Investigador postdoctoral, 2004 - 2006
  • Imperial College London, Reino Unido
    Investigador postdoctoral, 2007 - 2008
  • Fundación para el Fomento de la Investigación Sanitaria y Biomedica de la Comunidad Valenciana, FISABIO
    Gestor de proyectos, Responsable de la Unidad Transversal de Dirección de Proyectos, 2010 - 2011
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
Barcelona
Previously
Valencia - Erlangen - Dallas - Londres - Split
Story
Tagline
Renegade scientist. Venture capital investment analyst by day, still wannabe writer and entrepreneur by night.
Introduction
ENGLISH: Hi, my name is Carlos. I am a biochemist currently involved in the project Genagen which provides information on genetics and rare diseases to the general public (in Spanish). Previously I was a researcher in molecular microbiology (metabolic engineering) for 10 years. I am also interested in psychology, entrepreneurship and science fiction.

ESPAÑOL: Hola, soy Carlos. Bioquímico con amplio bagaje en investigación pero también con experiencia e interés en la docencia y la divulgación. Estoy involucrado en un proyecto, Genagen, que tiene el objetivo de acercar a quien pueda necesitarla información sobre la genética y las enfermedades hereditarias, así como proporcionar acceso a servicios de consulta de consejo genético y análisis genético. También tenemos un blog donde publicamos las últimas noticias sobre genética.
Education
  • Imperial College London
    MBA, 2008 - 2009
  • Universitat de València
    Doctor en Bioquímica (PhD Biochemistry), 1999 - 2004
  • Universitat de València
    Licenciado en Bioquímica (BS Biology + MS Biochemistry), 1993 - 1998
  • Uned
    Postgrado en Gestión de Proyectos (Project Management course), 2006 - 2007
  • Uned
    Grado en Psicología (BS Psychology), 2009 - 2015
Basic Information
Gender
Male