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Vangelis Simeonidis
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Vangelis
Vangelis

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Please vote for our colleage, Enrico Glaab, to win the Geoffrey Beene Challenge. Your support is very appreciated!
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The Geoffrey Beene Foundation Alzheimer’s Initiative is running their second online innovation challenge. The 2013 Geoffrey Beene Global NeuroDiscovery Challenge is a worldwide scientific competition to come up with new research ideas on the search for gender based differences In Alzheimer’s Disease. The winning submission will receive a $50,000 award for research.

My good colleague at the Luxembourg Centre for Systems Biomedicine, Enrico Glaab, is not only participating in the challenge, but has made it into the final round of the competition, and has a good chance of winning it. If you have a few seconds, please go to the Geoffrey Been Challenge website (link below) and show your support for Enrico Glaab. Just follow the links for "Scientific Community" or "Citizen Scientists" and vote for the project entitled: Male/Female Differences in Aging Brains in a Gene For Ubiquitin-Specific Peptidase 9 (USP9) as a Possible Cause for Increased Incidence of Alzheimer’s Disease in Older Women.

Everyone gets one vote every day until the 5th of November, so it would be great of you to come back and vote again, if you agree that Enrico deserves to win.
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The poster +Alexey Kolodkin and I have prepared for the ISMB/ECCB 2013 conference in Berlin is now online. Check it out if you are interested: http://www.slideshare.net/vangos7/ismb13-poster-o120-modeling-cellular
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A new article, published with my old MCISB colleagues.

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes

We present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a “cycle of knowledge” strategy, identifying the steps with most control over flux. Kinetic parameters of the individual isoenzymes within these steps are measured experimentally under a standardised set of conditions. Experimental strategies are applied to establish a set of in vivo concentrations for isoenzymes and metabolites. The data are integrated into a mathematical model that is used to predict a new set of metabolite concentrations and reevaluate the control properties of the system. This bottom-up modelling study reveals that control over the metabolic network most directly involved in yeast glycolysis is more widely distributed than previously thought.

http://www.sciencedirect.com/science/article/pii/S0014579313005012
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We have announced a position for a PhD student who will work on building models of human metabolism in order to study the role of iron and reactive oxygen species (ROS) in Parkinson’s disease. The student will be based at the Luxembourg Centre for Systems Biomedicine, with regular visits to the Manchester Centre for Integrative Systems Biology. For details and to apply:
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Thessaloniki: ultimate party city.
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"We're finding out with how little wisdom the world is governed, one Excel error at a time."
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Denis Noble on the importance of actively supporting research funding.
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