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Charles Weber

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        It is possible that survival of ebola virus victims would be much improved if an artificial fever were produced.
        I propose that fever evolved because bacteria grow poorly at elevated temperatures, and that the immune system evolved to become more active at elevated temperatures in order to take advantage of this bacterial weakness [1]. The immune system is markedly stimulated by a rise in temperature. This may be a response arising through interleuken-1 [3]. This phenomenon has been demonstrated for interleukin–1 and interleukin-2 in post operative hypothermia [4]. Heat also stimulates tumor necrosis factor [5]. The above could be the reason why the ability to create a fever arose [6]. Doubling time of pneumococcal meningitis in rabbits is markedly increased at fever temperature, and that bacteria did not grow at all at 41 degrees centigrade in either soy broth or cerebral fluid [7], so it seems that the efficacy of body temperature effectiveness is dependent on more than enhancement of the immune system. It is conceivable in view of their results that rather than the fever evolving in order to enhance an innate characteristic of the immune system, the fever evolved to take advantage of an innate ineffectiveness of most bacteria at high temperatures and the immune system then evolved to be most effective during a fever. I have often cured a cold within a couple hours with an infrared heat lamp directed to my nose and it has been advantageous for me against other infections near the surface of the body such as sore throats and infected skin damage. It is probably necessary to start the temperature treatment early in the disease for viruses, because that is the case for rabies in mice [8]. Also it is possible that its efficacy is on the secondary infections in the case of nose colds as much as on the virus. It is necessary to protect the eyes when applied near them though, because I have reason to believe their optical characteristics can change from a high temperature.
        I have cured abscessed teeth that were not cured by anacardic acids in raw cashew nuts [ http://charles_w.tripod.com/tooth.html ] and were very slow to respond to amoxicillin by heating the jaw with an infrared lamp in conjunction with the amoxicillin. It is possible that a laser directed on the tooth would work better and should be tried. It is very desirable to get rid of an infection first even if a root canal operation is desired, in my opinion, and certainly imperative if a root canal operation is financially or tactically impossible. Development of a device that heated the tooth up directly to the correct temperature should be very advantageous.
          I have cured quite a few other kinds of infections in the last couple of years as well with artificial fever.
                            Sincerely, Charles Weber
CONCLUSION
      It would be desirable to perform experiments to determine whether this is an effectivel phenomenon or not for ebola.  
REFERENCES
[1] Weber CE 2007 Creation of a local fever using an infrared lamp to cure a tooth abscess. Medical Hypotheses 68; 458.
[2] Merchant M, Williams S, Trosclair PL 3rd, Elsey RM, Mills K. 2007 Febrile response to infection in the American alligator (Alligator mississippiensis). Comp Biochem Physiol A Mol Integr Physiol. 2007 Dec;148(4):921-5..
[3] Hanson DE, Murphy PA, Silicano R, Shin HS. The effect of temperature on the activation of thymocytes by interleukin I & II. Journal of Immunol. 1983; 130: 216,
[4] Beilin B, Shavit Y,  Razumovsky J,  Wolloch Y, Zeidel A, Bessler H. Effects of Mild Perioperative Hypothermia on Cellular Immune Responses. Anesthesiology. 1998; 89(5):1133-1140,
[5] Zellner M, Hergovics N, Roth E, Jilma B, Spittler A, Oehler R. Human monocyte stimulation by experimental whole body hyperthermia. Wien. Klin. Wochenschr. 2002 Feb 15; 114(3): 73-75.
[6] Kluger MJ.  The evolution and adabtive value of fever. American Sci. 1978; 66: 38-43.
[7] Small PM, Täuber MG, Hackbarth CJ, Sande MA. Influence of body temperature on bacterial growth rates in experimental pneumococcal meningitis in rabbits. Infect Immun. 1986 May; 52(2): 484–487.
[8] Bell JF, and Moore GJ. Effects of High Ambient Temperature on Various Stages of Rabies Virus Infection in Mice. Infect Immun. 1974 September; 10(3): 510–515.
[9]  Meyers WM Shelly WM Conner DH  Heat treatment of Mycobacterium ulcerans infections without surgical incision. The American Journal of Tropical Medicine and Hygeine.1974 23(5); 924-929.
              Sincerely, Charles Weber
 
 
 
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Charles Weber

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          I suspect that you will find interesting a hypothesis that most of the large lava flows on Earth and Mars result from disruption of the crust at the antipode (opposite side of a sphere) from a huge meteorite impact. You may see it discussed in http://charles_w.tripod.com/antipode.html  and in the journal article http://gsjournal.net/Science-Journals/Research%20Papers-Geology/Download/4671  for Earth and  http://charles_w.tripod.com/dweber/mars_volcanos/mars_volcanos2.html  for Mars.
          The chance that there would be a lava flow at the antipode of each of the large known meteorite impact sites of the same age by sheer coincidence is extremely small. You may see statistics on the incidence of meteorite impacts of various sizes in http://www.glencoe.com/sec/computered/col/chapter5/search_engines/yahoo/yahoo_6.html  , scroll down.
.
                    Sincerely,  Charles Weber
PS You may see a discussion of the antipode effect when a meteorite strikes at an angle in http://www.newgeology.us/presentation35.html
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         I suspect that anacardic acids would kill Streptococcus and Staphylococcus bacteria and other gram positive infections such as anthrax and maybe tuberculosis.       
         I have found that the anacardic acids in raw cashew nuts and maybe mangoes do an excellent job of curing an abscess from gram positive bacteria, which are the most prevalent cause of tooth decay and tooth aches You may see my article on this subject at; http://charles_w.tripod.com/tooth.html   . It is also discussed briefly in the 2005 edition of Medical Hypotheses, 65; 289-292. Wikipedia discusses anacardic acids in http://en.wikipedia.org/wiki/Anacardic_acid  .
      I would like to urge you to explore making these medicines available in the pure form from pharmacies for a Streptococcus medicine or in tooth paste. This would have several advantages; 1. a variety of [C1] application methods would be possible,                                                                                               needles, brushes, swabs, sprays, and etc. 2. It would probably eliminate allergy. 3. It would probably be less expensive than cashews. 4. It would be easier to apply massively locally. 4. It would be easier to test against the pathogenic species involved. 5. It would be more emotionally acceptable to the medical profession who tend to prefer chemicals over anything as amateurish as natural products. 6 It would be easier to control amounts. 7. It would be easier to carry it on camping trips, etc. 7. It would probably have an infinite shelf life.
        Anacardics would be much more effective in killing decay bacteria than fluoride and without the dangerous side effects (see http://charles_w,tripod.com/fluoride.html ). This would be especially valuable since these medicines would probably prove to be valuable against other gram positive diseases such as acne, leprosy, Streptococci, Staphylococcus aureus, anthrax, Listeria monocytogenes, Actinomyces naeslundi, Corynebacterium diphtheriae, Streptococcus agalactiae, Propionibacterium spp, and maybe even tuberculosis as well.
     Acute Streptococcus pyogenes infections may present as pharyngitis (strep throat), scarlet fever (rash), impetigo (infection of the superficial layers of the skin) or cellulitis (infection of the deep layers of the skin). Invasive, toxigenic infections can result in necrotizing fasciitis, myositis and streptococcal toxic shock syndrome. Patients may also develop immune-mediated post-streptococcal sequelae, such as acute rheumatic fever and acute glomerulonephritis, following acute infections caused by Streptococcus pyogenes.  Streptococcus pyogenes produces a wide array of virulence factors and a very large number of diseases. Virulence factors of Group A streptococci include: (1) M protein, fibronectin-binding protein (Protein F) and lipoteichoic acid for adherence; (2) hyaluronic acid capsule as an immunological disguise and to inhibit phagocytosis; M-protein to inhibit phagocytosis (3) invasins such as streptokinase, streptodornase (DNase B), hyaluronidase, and streptolysins; (4) exotoxins, such as pyrogenic (erythrogenic) toxin which causes the rash of scarlet fever and systemic toxic shock syndrome. (see http://textbookofbacteriology.net/themicrobialworld/strep.html )
 
 
                             Sincerely, Charles Weber
PS  Dr. Rastmanesh, a nutritionist from Iran, would like to secure a position in an English speaking university because of religious or political problems. He has an impressive CV. If you know of an opening I will send you his CV. It would be a travesty to leave that fine scientist in that criminal country after he got rid of rheumatoid arthritis for us.
 
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+Charles Weber interesting. Thank you for this.
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        I suspect that a poison, capsaicin in chili pepper, is one of the causes of diabetes, especially in combination with a copper deficiency. I have published this in the 2008 Medical Hypotheses 71 p 323-324, entitled “Does capsaicin in chili cause diabetes?”. You may also see some discussion of this in  http://charles_w.tripod.com/diabetes.html . So it would be a good idea not to recommend chili in diets until such time as the matter is established on animal experiments, or to use capsaicin as a medicine. It is not impossible that capsaicin causes other problems as well.
        Dr. Beale speaks of having a worm that one can do experiments involving diabetes on. Maybe one of your students could use such a technique. His URL is http://www.ttuhsc.edu/som/cbb/faculty/beale.aspx  .
       You may see how to increase copper in the diet in  http://charles_w.tripod.com/copper3.html  (chili probably operates synergistically with a copper deficiency).
         You also may find a book about potassium nutrition as it relates to heart disease, gout, rheumatoid arthritis, high blood pressure, and diabetes, useful for your library. Its availability through Paypal  along with its introduction and table of contents may be accessed in http://charles_w.tripod.com/book.html .
            Sincerely,  Charles Weber
PS  Dr. Rastmanesh, a nutritionist from Iran, would like to secure a position in an English speaking university because of religious or political  problems. He has an impressive CV. If you know of an opening I will send you his CV. It would be a travesty to leave that fine scientist in that criminal country after he got rid of rheumatoid arthritis for us.
 
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Charles Weber

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         I suspect that anacardic acids would kill Streptococcus and Staphylococcus bacteria and other gram positive infections such as anthrax and maybe tuberculosis.       
         I have found that the anacardic acids in raw cashew nuts and maybe mangoes do an excellent job of curing an abscess from gram positive bacteria, which are the most prevalent cause of tooth decay and tooth aches You may see my article on this subject at; http://charles_w.tripod.com/tooth.html   . It is also discussed briefly in the 2005 edition of Medical Hypotheses, 65; 289-292. Wikipedia discusses anacardic acids in http://en.wikipedia.org/wiki/Anacardic_acid  .
      I would like to urge you to explore making these medicines available in the pure form from pharmacies for a Streptococcus medicine or in tooth paste. This would have several advantages; 1. a variety of [C1] application methods would be possible,                                                                                               needles, brushes, swabs, sprays, and etc. 2. It would probably eliminate allergy. 3. It would probably be less expensive than cashews. 4. It would be easier to apply massively locally. 4. It would be easier to test against the pathogenic species involved. 5. It would be more emotionally acceptable to the medical profession who tend to prefer chemicals over anything as amateurish as natural products. 6 It would be easier to control amounts. 7. It would be easier to carry it on camping trips, etc. 7. It would probably have an infinite shelf life.
        Anacardics would be much more effective in killing decay bacteria than fluoride and without the dangerous side effects (see http://charles_w,tripod.com/fluoride.html ). This would be especially valuable since these medicines would probably prove to be valuable against other gram positive diseases such as acne, leprosy, Streptococci, Staphylococcus aureus, anthrax, Listeria monocytogenes, Actinomyces naeslundi, Corynebacterium diphtheriae, Streptococcus agalactiae, Propionibacterium spp, and maybe even tuberculosis as well.
     Acute Streptococcus pyogenes infections may present as pharyngitis (strep throat), scarlet fever (rash), impetigo (infection of the superficial layers of the skin) or cellulitis (infection of the deep layers of the skin). Invasive, toxigenic infections can result in necrotizing fasciitis, myositis and streptococcal toxic shock syndrome. Patients may also develop immune-mediated post-streptococcal sequelae, such as acute rheumatic fever and acute glomerulonephritis, following acute infections caused by Streptococcus pyogenes.  Streptococcus pyogenes produces a wide array of virulence factors and a very large number of diseases. Virulence factors of Group A streptococci include: (1) M protein, fibronectin-binding protein (Protein F) and lipoteichoic acid for adherence; (2) hyaluronic acid capsule as an immunological disguise and to inhibit phagocytosis; M-protein to inhibit phagocytosis (3) invasins such as streptokinase, streptodornase (DNase B), hyaluronidase, and streptolysins; (4) exotoxins, such as pyrogenic (erythrogenic) toxin which causes the rash of scarlet fever and systemic toxic shock syndrome. (see http://textbookofbacteriology.net/themicrobialworld/strep.html )
 
 
                             Sincerely, Charles Weber
PS  Dr. Rastmanesh, a nutritionist from Iran, would like to secure a position in an English speaking university because of religious or political problems. He has an impressive CV. If you know of an opening I will send you his CV. It would be a travesty to leave that fine scientist in that criminal country after he got rid of rheumatoid arthritis for us.
 
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Everyone asks why a madman opened fire. My question  is  why did all the return fire miss the mad man? Maybe people need target practice!  If the problem was that they were all helpless, in the future they had better at least pack pepper spray.
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Charles Weber

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      You are almost certain to find valuable information for your family's health in articles about potassium nutrition as pertaining to heart disease, rheumatoid arthritis, and gout, or copper nutrition as pertaining to hemorrhoids, herniated discs, high cholesterol, and aneurisms, and anacardic compounds in cashew nuts to cure tooth and gram positive bacterial infections in articles listed in http://charles_w.tripod.com/index.html  .
                      Sincerely, Charles Weber
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          Potassium deficiency is deeply involved in gout and high uric acid as an accentuating factor because uric acid is less soluble in acidic urine. Potassium bicarbonate supplements will reverse this. In view of the fact that this is not considered by current rheumatologists, it would be very valuable for you to bring it into your future writing. It is not only that potassium is not considered by physicians in regard to gout, many of them do not even believe that a potassium deficiency is likely. This even though many of them prescribe what are actually supplements, but prescribed under euphemistic terms such as salt substitutes, sodium free baking powder, ORT salts (oral rehydration therapy for diarrhea), polarizing solutions, GIK (glucose, insulin, potassium) salts, vegetables, or glucosamine.  A deficiency is further defined out of existence by defining the blood serum content normal as 4.2 when the actual figure is 4.8. For gout, though, the chloride is not acceptable. But potassium bicarbonate powder dissolved in fruit juice or half teaspoon sprinkled on cereal will work very well. It may be obtained from businesses which add it to wine. You may see an article on this concept in  http://www.webmedcentral.com/article_view/4217  . If you supplement potassium, be very certain that vitamin B-1 is adequate, because otherwise heart disease can be triggered (see http://charles_w.tripod.com/kandthiamin.html ).
                               Sincerely, Charles Weber
 
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Charles Weber

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        I suspect that a poison, capsaicin in chili pepper, is one of the causes of diabetes, especially in combination with a copper deficiency. I have published this in the 2008 Medical Hypotheses 71 p 323-324, entitled “Does capsaicin in chili cause diabetes?”. You may also see some discussion of this in  http://charles_w.tripod.com/diabetes.html . So it would be a good idea not to recommend chili in diets until such time as the matter is established on animal experiments, or to use capsaicin as a medicine. It is not impossible that capsaicin causes other problems as well.
        Dr. Beale speaks of having a worm that one can do experiments involving diabetes on. Maybe one of your students could use such a technique. His URL is http://www.ttuhsc.edu/som/cbb/faculty/beale.aspx  .
       You may see how to increase copper in the diet in  http://charles_w.tripod.com/copper3.html  (chili probably operates synergistically with a copper deficiency).
         You also may find a book about potassium nutrition as it relates to heart disease, gout, rheumatoid arthritis, high blood pressure, and diabetes, useful for your library. Its availability through Paypal  along with its introduction and table of contents may be accessed in http://charles_w.tripod.com/book.html .
            Sincerely,  Charles Weber
PS  Dr. Rastmanesh, a nutritionist from Iran, would like to secure a position in an English speaking university because of religious or political  problems. He has an impressive CV. If you know of an opening I will send you his CV. It would be a travesty to leave that fine scientist in that criminal country after he got rid of rheumatoid arthritis for us.
 
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    Insufficient potassium and vitamin B-1 (thiamin) can not damage the heart significantly when both are deficient. This has important safety implications when supplementing each during heart disease, arrhythmias, rheumatoid arthritis, high blood pressure, gout, beri-beri, or diabetes caused or influenced by the deficiency of one of them. It is extremely important to know which kind of heart disease is involved. You may see this discussed in detail in  http://charles_w.tripod.com/kandthiamin.html  . This is probably the primary reason why the medical profession has not been able to prevent heart disease up to date and why potassium supplements cause neutral mortality statistics. Researchers almost across the board think that potassium has little impact on the body or/and is never deficient. This is a mistaken assumption. Most food processing procedures cause losses. Enormous attention is given to a single murder or handful of murders, while at the same time the food industry causing 500 thousand deaths from heart disease alone, gets almost no coverage. This is because a considerable fraction of their profits goes to promulgating these disasters by advertising and bribing politicians. Even the medical profession is responsible by procedures in hospital cafeterias.
       Copper is crucial for strength of arteries because of its role as part of lysil oxidase, which cross links elastin tissue. A deficiency is probably the main cause of aneurisms and therefore many strokes, hemorrhoids, and many bleeding problems, as well as high blood cholesterol and is probably involved by a synergistic affect in the cause of diabetes by chili pepper (see  http://charles_w.tripod.com/diabetes.html ). You may see how to increase copper from food in http://charles_w.tripod.com/copper3.html  and a discussion of copper physiology in  http://charles_w.tripod.com/copper.html  . Finding ways to repair the heart is useful, but there is no good substitute for not damaging it in the first place.
         You also may find a book about potassium nutrition as it relates to heart disease, gout, rheumatoid arthritis, high blood pressure, and diabetes, useful for your library. Its availability is through Paypal along with its introduction, table of contents and first two chapters may be accessed in http://charles_w.tripod.com/book.html .
           Sincerely,  Charles Weber   isoptera@att.net
PS  Dr. Rastmanesh, a nutritionist from Iran, would like to secure a position in an English speaking university. He has an impressive CV. If you know of an opening I will send you his CV. It is a travesty to leave that fine researcher over in that criminal country after he has gotten rid of rheumatoid arthritis for us.
 
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Charles Weber

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          Potassium deficiency is deeply involved in gout and high uric acid as an accentuating factor because uric acid is less soluble in acidic urine. Potassium bicarbonate supplements will reverse this. In view of the fact that this is not considered by current rheumatologists, it would be very valuable for you to bring it into your future writing. It is not only that potassium is not considered by physicians in regard to gout, many of them do not even believe that a potassium deficiency is likely. This even though many of them prescribe what are actually supplements, but prescribed under euphemistic terms such as salt substitutes, sodium free baking powder, ORT salts (oral rehydration therapy for diarrhea), polarizing solutions, GIK (glucose, insulin, potassium) salts, vegetables, or glucosamine.  A deficiency is further defined out of existence by defining the blood serum content normal as 4.2 when the actual figure is 4.8. For gout, though, the chloride is not acceptable. But potassium bicarbonate powder dissolved in fruit juice or half teaspoon sprinkled on cereal will work very well. It may be obtained from businesses which add it to wine. You may see an article on this concept in  http://www.webmedcentral.com/article_view/4217  . If you supplement potassium, be very certain that vitamin B-1 is adequate, because otherwise heart disease can be triggered (see http://charles_w.tripod.com/kandthiamin.html ).
                               Sincerely, Charles Weber
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         It is my contention that rheumatoid arthritis is either caused by a potassium deficiency or is greatly enabled by one (Potassium in the etiology of rheumatoid arthritis and heart infarction. 1974 Journal of Applied Nutrition. 26; p40. ) (Potassium deficiency as a cause of rheumatoid arthritis. 2000 Townsend Letter for Doctors and Patients. 208; 74-76. ) ( http://charles_w.tripod.com/arthritis.html ). Dr. Reza Rastmanesh has performed a clinical trial that establishes this (Rastmanesh R.  2008 A pilot study of potassium supplementation in treatment of hypokalemic patients with rheumatoid arthritis: A randomized, double-blinded placebo controlled trial. The Journal of Pain. 9, issue 8; 722-731. ). For the abstract see http://www.ncbi.nlm.nih.gov/pubmed/19560875 .
         Potassium should be automatically prescribed for rheumatoid arthritis because getting potassium up to normal from the low values in all RA patients (LaCelle PL et al 1964 An investigation of total body potassium in patients with rheumatoid arthritis. Proceedings Ann. Meeting of the Rheumatism Association, Arthritis & Rheumatism 7; 321 ) (Sambrook PN, Ansell BM, Foster S, Gumpel JM, Hesp R, Reeve J, Zanelli JM 1985 Bone turnover in early rheumatoid arthritis. 1. Biochemical and kinetic indexes. Ann Rheum Dis. Sep;44(9):575-9. ) is slow, even with a high unprocessed vegetable diet. There are tasty foods that are especially rich in potassium ( http://www.rheumatoidarthritisprogram.com/potassium-and-ra/ ).
        However it is important that thiamin (vitamin B-1) be adequate when supplementing with potassium because heart disease can not  materialize when both are deficient, but will show up if only one of those is deficient (http://charles_w.tripod.com/kandthiamin.html ). This is probably the primary reason why heart disease is a main cause of death in rheumatoid arthritis patients.
         In view of the fact that this is not considered by current rheumatologists, it would be very valuable for you to bring it into your future research. It is not only that potassium is not considered by physicians in regard to RA, most of them do not even believe that a potassium deficiency is likely. This even though many of them prescribe what are actually supplements, but prescribed under euphemistic terms such as salt substitutes, sodium free baking powder, ORT salts (oral rehydration therapy for diarrhea), polarizing solutions, GIK (glucose, insulin, potassium) salts, vegetables, or glucosamine.  A deficiency is further defined out of existence by defining the blood serum content normal as 4.2 when the actual figure is 4.8.
                               Sincerely, Charles Weber    828 692 5816
PS   You may find interesting an article that presents the history of arthritis research in http://charles_w.tripod.com/arthritis2.html 
 
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